ENSMUSG00000050931


Mus musculus

Features
Gene ID: ENSMUSG00000050931
  
Biological name :Sgms2
  
Synonyms : Phosphatidylcholine:ceramide cholinephosphotransferase 2 / Q9D4B1 / Sgms2
  
Possible biological names infered from orthology : Q8NHU3 / sphingomyelin synthase 2
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: G3
Gene start: 131318985
Gene end: 131491411
  
Corresponding Affymetrix probe sets: 10502224 (MoGene1.0st)   1428663_at (Mouse Genome 430 2.0 Array)   1429029_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000143170
Ensembl peptide - ENSMUSP00000087713
Ensembl peptide - ENSMUSP00000114192
NCBI entrez gene - 74442     See in Manteia.
MGI - MGI:1921692
RefSeq - XM_011240250
RefSeq - XM_006502196
RefSeq - XM_006502197
RefSeq - XM_006502199
RefSeq - XM_011240249
RefSeq - NM_028943
RefSeq - XM_006502193
RefSeq - XM_006502194
RefSeq Peptide - NP_083219
swissprot - D3YVS9
swissprot - A0A0G2JFH1
swissprot - Q9D4B1
Ensembl - ENSMUSG00000050931
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SGMS2ENSGALG00000010535Gallus gallus
 SGMS2ENSG00000164023Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sgms1 / Q8VCQ6 / Phosphatidylcholine:ceramide cholinephosphotransferase 1 / sphingomyelin synthase 1*ENSMUSG0000004045157
Samd8 / Q9DA37 / sterile alpha motif domain containing 8 / Q96LT4*ENSMUSG0000002177036


Protein motifs (from Interpro)
Interpro ID Name
 IPR025749  Sphingomyelin synthase-like domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006665 sphingolipid metabolic process IEA
 biological_processGO:0006686 sphingomyelin biosynthetic process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0046513 ceramide biosynthetic process IMP
 biological_processGO:1905373 ceramide phosphoethanolamine biosynthetic process IMP
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030173 integral component of Golgi membrane IEA
 cellular_componentGO:0030176 integral component of endoplasmic reticulum membrane IBA
 molecular_functionGO:0002950 ceramide phosphoethanolamine synthase activity IMP
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0033188 sphingomyelin synthase activity IMP
 molecular_functionGO:0047493 ceramide cholinephosphotransferase activity IEA


Pathways (from Reactome)
Pathway description
Sphingolipid de novo biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000188 abnormal circulating glucose level "anomalous concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cacna1ctm3Hfm/Cacna1ctm4Hfm,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hbegftm2Mek/Hbegftm2Mek
Genetic Background: B6.Cg-Hbegftm2Mek

 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
Show

Allelic Composition: Cacna1ctm3Hfm/Cacna1ctm4Hfm,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0002310 resistance to fatty liver development "less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cacna1ctm3Hfm/Cacna1ctm4Hfm,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0002446 abnormal macrophage morphology "anomalous structure, number, or composition of the large mononuclear phagocytic cells found in most tissues of the body" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hbegftm2Mek/Hbegftm2Mek
Genetic Background: B6.Cg-Hbegftm2Mek

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hbegftm2Mek/Hbegftm2Mek
Genetic Background: B6.Cg-Hbegftm2Mek

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cacna1ctm3Hfm/Cacna1ctm4Hfm,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Cacna1ctm3Hfm/Cacna1ctm4Hfm,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cacna1ctm3Hfm/Cacna1ctm4Hfm,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0005416 abnormal circulating protein level "anomalous blood concentration of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hbegftm2Mek/Hbegftm2Mek
Genetic Background: B6.Cg-Hbegftm2Mek

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Samd8tm2.2Kwi/Samd8tm2.2Kwi
Genetic Background: involves: 129P2/OlaHsd

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hbegftm2Mek/Hbegftm2Mek
Genetic Background: B6.Cg-Hbegftm2Mek

Allelic Composition: Sgms2tm1Kenw/Sgms2tm1Kenw
Genetic Background: B6.129S2-Sgms2tm1Kenw

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Sgms2tm1Kenw/Sgms2tm1Kenw
Genetic Background: B6.129S2-Sgms2tm1Kenw

 MP:0009289 decreased epididymal fat pad weight 
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Allelic Composition: Sgms2tm1Kenw/Sgms2tm1Kenw
Genetic Background: B6.129S2-Sgms2tm1Kenw

 MP:0009823 abnormal sphingomyelin level "deviation in the expected amount of any of a group of phospholipids that are found especially in, but not restricted to, nerve tissue and yield sphingosine, choline, a fatty acid, and phosphoric acid upon hydrolysis" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hbegftm2Mek/Hbegftm2Mek
Genetic Background: B6.Cg-Hbegftm2Mek

Allelic Composition: Sgms2tm1Jia/Sgms2tm1Jia
Genetic Background: Not Specified

Allelic Composition: Samd8tm1Jia/Samd8tm1Jia,Sgms2tm1Jia/Sgms2tm1Jia
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Samd8tm1.1Kwi/Samd8tm1.1Kwi,Sgms2tm1Jia/Sgms2tm1Jia
Genetic Background: involves: 129P2/OlaHsd

 MP:0010080 abnormal hepatocyte physiology "any functional anomaly of the main structural specialized epithelial cells which normally organize into interconnected plates called lobules" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hbegftm2Mek/Hbegftm2Mek
Genetic Background: B6.Cg-Hbegftm2Mek

 MP:0010163 hemolysis "destruction of erythrocytes such that hemoglobin is released from the cells; may occur by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Hbegftm2Mek/Hbegftm2Mek
Genetic Background: B6.Cg-Hbegftm2Mek

 MP:0012232 abnormal ceramide level 
Show

Allelic Composition: Sgms2tm1Jia/Sgms2tm1Jia
Genetic Background: Not Specified

Allelic Composition: Samd8tm1Jia/Samd8tm1Jia,Sgms2tm1Jia/Sgms2tm1Jia
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Samd8tm1.1Kwi/Samd8tm1.1Kwi,Sgms2tm1Jia/Sgms2tm1Jia
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Samd8tm2.2Kwi/Samd8tm2.2Kwi,Sgms2tm1Jia/Sgms2tm1Jia
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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