MP:0000934 | abnormal telencephalon development | "malformed or incomplete differentiation of the anterior division of the embryonic prosencephalon " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840] |
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Allelic Composition: Islr2tm1.1Ddg/Islr2tm2.1Ddg,Emx1tm1(cre)Krj/Emx1+ Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * SJL
Allelic Composition: Islr2tm1.1Ddg/Islr2tm2.1Ddg,Tg(mI56i-cre,EGFP)1Kc/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL
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MP:0000937 | abnormal motor neuron morphology | "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of motor impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159] |
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Allelic Composition: Islr2tm1.1Ddg/Islr2tm1.1Ddg,Rettm1.1Ddg/Rettm1.1Ddg Genetic Background: involves: 129S6/SvEvTac * BALB/cJ * C57BL/6
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MP:0000961 | abnormal dorsal root ganglia morphology | "malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159] |
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Allelic Composition: Islr2tm1.1Ddg/Islr2tm1.1Ddg,Rettm1.1Ddg/Rettm1.1Ddg Genetic Background: involves: 129S6/SvEvTac * BALB/cJ * C57BL/6
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MP:0002067 | abnormal sensory capabilities/reflexes/nociception | "inability or altered ability to respond to a sensory stimulus" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Islr2tm1.1Ddg/Islr2tm1.1Ddg,Rettm1.1Ddg/Rettm1.1Ddg Genetic Background: involves: 129S6/SvEvTac * BALB/cJ * C57BL/6
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MP:0002081 | perinatal lethality | "death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Islr2tm1.1Ddg/Islr2tm1.1Ddg,Rettm1.1Ddg/Rettm1.1Ddg Genetic Background: involves: 129S6/SvEvTac * BALB/cJ * C57BL/6
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MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Grb10tm1.1Fliu/Grb10tm1.1Fliu,Tg(Pdx1-cre)6Tuv/0 Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N
Allelic Composition: Islr2tm1.1Ddg/Islr2tm2.1Ddg,Tg(mI56i-cre,EGFP)1Kc/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL
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MP:0002152 | abnormal brain morphology | "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk] |
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Allelic Composition: Islr2tm1.1Ddg/Islr2tm2.1Ddg,Emx1tm1(cre)Krj/Emx1+ Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * SJL
Allelic Composition: Islr2tm1.1Ddg/Islr2tm2.1Ddg,Tg(mI56i-cre,EGFP)1Kc/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL
Allelic Composition: Islr2tm1.1Ddg/Islr2tm1.1Ddg Genetic Background: involves: 129S6/SvEvTac
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MP:0002882 | abnormal neuron | "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003] |
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Allelic Composition: Islr2tm1.1Ddg/Islr2tm1.1Ddg,Rettm1.1Ddg/Ret+ Genetic Background: involves: 129S6/SvEvTac * BALB/cJ * C57BL/6
Allelic Composition: Islr2tm1.1Ddg/Islr2tm1.1Ddg,Rettm1.1Ddg/Rettm1.1Ddg Genetic Background: involves: 129S6/SvEvTac * BALB/cJ * C57BL/6
Allelic Composition: Islr2tm1.1Ddg/Islr2tm1.1Ddg Genetic Background: involves: 129S6/SvEvTac * BALB/cJ * C57BL/6
Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Islr2tm1.1Ddg/Islr2tm1.1Ddg Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * BALB/cJ * C57BL/6
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MP:0005404 | abnormal axon morphology | "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Islr2tm1.1Ddg/Islr2tm1.1Ddg Genetic Background: involves: 129S6/SvEvTac * BALB/cJ * C57BL/6
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MP:0008128 | abnormal brain internal capsule morphology | "any structural anomaly of the area of white matter in the brain that lies between the lenticular and caudate nuclei, and contains a group of myelinated ascending and descending axonal fiber tracts that connects the cerebral cortex to the brain stem and spinal cord" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Islr2tm1.1Ddg/Islr2tm2.1Ddg,Emx1tm1(cre)Krj/Emx1+ Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * SJL
Allelic Composition: Islr2tm1.1Ddg/Islr2tm2.1Ddg,Tg(mI56i-cre,EGFP)1Kc/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL
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MP:0008129 | absent brain internal capsule | "absence of the area of white matter in the brain that lies between the lenticular and caudate nuclei, and contains a group of myelinated ascending and descending axonal fiber tracts that connects the cerebral cortex to the brain stem and spinal cord" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Islr2tm1.1Ddg/Islr2tm1.1Ddg Genetic Background: involves: 129S6/SvEvTac
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MP:0008415 | abnormal neurite morphology | "any structural anomaly of a neuronal process, either a dendrite or an axon in vivo, or a filamentous projection from a neuron such as is seen in tissue culture" [PMID:12951572] |
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Allelic Composition: Islr2tm1.1Ddg/Islr2tm1.1Ddg Genetic Background: involves: 129S6/SvEvTac * BALB/cJ * C57BL/6
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MP:0008948 | decreased neuron number | "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663] |
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Allelic Composition: Islr2tm1.1Ddg/Islr2tm1.1Ddg Genetic Background: involves: 129S6/SvEvTac * BALB/cJ * C57BL/6
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MP:0009970 | increased hippocampus pyramidal cell number | "increased number of the projection neurons in the pyramidal layer of the hippocampus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Islr2tm1.1Ddg/Islr2tm1.1Ddg Genetic Background: involves: 129S6/SvEvTac
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MP:0012484 | decreased corticospinal tract size | "reduced size of the corticospinal fibers that arise from the pyramidal cells within the cerebral cortex layer V of the precentral motor area, the premotor area and the postcentral gyrus, then descend into and through the medulla to form the lateral corticospinal tract and the anterior corticospinal tract" [ISBN:0-683-40008-8] |
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Allelic Composition: Islr2tm1.1Ddg/Islr2tm2.1Ddg,Tg(mI56i-cre,EGFP)1Kc/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL
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