ENSMUSG00000051243


Mus musculus

Features
Gene ID: ENSMUSG00000051243
  
Biological name :Islr2
  
Synonyms : Immunoglobulin superfamily containing leucine-rich repeat protein 2 / Islr2 / Q5RKR3
  
Possible biological names infered from orthology : immunoglobulin superfamily containing leucine rich repeat 2 / Q6UXK2
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: B
Gene start: 58196297
Gene end: 58204319
  
Corresponding Affymetrix probe sets: 10594048 (MoGene1.0st)   1434421_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000149095
Ensembl peptide - ENSMUSP00000130879
Ensembl peptide - ENSMUSP00000149195
Ensembl peptide - ENSMUSP00000151153
Ensembl peptide - ENSMUSP00000151098
Ensembl peptide - ENSMUSP00000150877
Ensembl peptide - ENSMUSP00000150118
Ensembl peptide - ENSMUSP00000149920
Ensembl peptide - ENSMUSP00000149680
Ensembl peptide - ENSMUSP00000109781
Ensembl peptide - ENSMUSP00000127228
Ensembl peptide - ENSMUSP00000129328
Ensembl peptide - ENSMUSP00000130322
NCBI entrez gene - 320563     See in Manteia.
MGI - MGI:2444277
RefSeq - XM_006511234
RefSeq - NM_001161535
RefSeq - NM_001161536
RefSeq - NM_001161537
RefSeq - NM_001161538
RefSeq - NM_001161539
RefSeq - NM_001161540
RefSeq - NM_001161541
RefSeq - NM_177193
RefSeq - XM_006511229
RefSeq - XM_006511230
RefSeq - XM_006511231
RefSeq - XM_006511232
RefSeq - XM_006511233
RefSeq Peptide - NP_001155008
RefSeq Peptide - NP_001155007
RefSeq Peptide - NP_001155009
RefSeq Peptide - NP_001155010
RefSeq Peptide - NP_001155011
RefSeq Peptide - NP_001155012
RefSeq Peptide - NP_001155013
RefSeq Peptide - NP_796167
swissprot - A0A1L1SS00
swissprot - A0A1L1SSZ4
swissprot - A0A1L1SQV1
swissprot - E9Q9N7
swissprot - A0A1L1SVD6
swissprot - A0A1L1SV86
swissprot - A0A1L1SUR1
swissprot - Q5RKR3
swissprot - A0A1L1SSI6
Ensembl - ENSMUSG00000051243
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 islr2ENSDARG00000051875Danio rerio
 ENSGALG00000021525Gallus gallus
 ISLR2ENSGALG00000029151Gallus gallus
 ISLR2ENSG00000167178Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Islr / Q6GU68 / Immunoglobulin superfamily containing leucine-rich repeat protein / O14498* / immunoglobulin superfamily containing leucine rich repeat*ENSMUSG0000003720626
Lrit3 / W8DXL4 / Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3 / Q3SXY7* / leucine rich repeat, Ig-like and transmembrane domains 3*ENSMUSG0000009386519
Lrit1 / Q8K099 / Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1 / Q9P2V4* / leucine rich repeat, Ig-like and transmembrane domains 1*ENSMUSG0000004104417
Lrit2 / Q6PFC5 / Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 2 / A6NDA9* / leucine rich repeat, Ig-like and transmembrane domains 2*ENSMUSG0000004341815


Protein motifs (from Interpro)
Interpro ID Name
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR007110  Immunoglobulin-like domain
 IPR013783  Immunoglobulin-like fold
 IPR032675  Leucine-rich repeat domain superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0045773 positive regulation of axon extension IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000934 abnormal telencephalon development "malformed or incomplete differentiation of the anterior division of the embryonic prosencephalon " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
Show

Allelic Composition: Islr2tm1.1Ddg/Islr2tm2.1Ddg,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Islr2tm1.1Ddg/Islr2tm2.1Ddg,Tg(mI56i-cre,EGFP)1Kc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL

 MP:0000937 abnormal motor neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of motor impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Islr2tm1.1Ddg/Islr2tm1.1Ddg,Rettm1.1Ddg/Rettm1.1Ddg
Genetic Background: involves: 129S6/SvEvTac * BALB/cJ * C57BL/6

 MP:0000961 abnormal dorsal root ganglia morphology "malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]
Show

Allelic Composition: Islr2tm1.1Ddg/Islr2tm1.1Ddg,Rettm1.1Ddg/Rettm1.1Ddg
Genetic Background: involves: 129S6/SvEvTac * BALB/cJ * C57BL/6

 MP:0002067 abnormal sensory capabilities/reflexes/nociception "inability or altered ability to respond to a sensory stimulus" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Islr2tm1.1Ddg/Islr2tm1.1Ddg,Rettm1.1Ddg/Rettm1.1Ddg
Genetic Background: involves: 129S6/SvEvTac * BALB/cJ * C57BL/6

 MP:0002081 perinatal lethality "death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Islr2tm1.1Ddg/Islr2tm1.1Ddg,Rettm1.1Ddg/Rettm1.1Ddg
Genetic Background: involves: 129S6/SvEvTac * BALB/cJ * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Grb10tm1.1Fliu/Grb10tm1.1Fliu,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

Allelic Composition: Islr2tm1.1Ddg/Islr2tm2.1Ddg,Tg(mI56i-cre,EGFP)1Kc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
Show

Allelic Composition: Islr2tm1.1Ddg/Islr2tm2.1Ddg,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Islr2tm1.1Ddg/Islr2tm2.1Ddg,Tg(mI56i-cre,EGFP)1Kc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL

Allelic Composition: Islr2tm1.1Ddg/Islr2tm1.1Ddg
Genetic Background: involves: 129S6/SvEvTac

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Islr2tm1.1Ddg/Islr2tm1.1Ddg,Rettm1.1Ddg/Ret+
Genetic Background: involves: 129S6/SvEvTac * BALB/cJ * C57BL/6

Allelic Composition: Islr2tm1.1Ddg/Islr2tm1.1Ddg,Rettm1.1Ddg/Rettm1.1Ddg
Genetic Background: involves: 129S6/SvEvTac * BALB/cJ * C57BL/6

Allelic Composition: Islr2tm1.1Ddg/Islr2tm1.1Ddg
Genetic Background: involves: 129S6/SvEvTac * BALB/cJ * C57BL/6

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Islr2tm1.1Ddg/Islr2tm1.1Ddg
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Islr2tm1.1Ddg/Islr2tm1.1Ddg
Genetic Background: involves: 129S6/SvEvTac * BALB/cJ * C57BL/6

 MP:0008128 abnormal brain internal capsule morphology "any structural anomaly of the area of white matter in the brain that lies between the lenticular and caudate nuclei, and contains a group of myelinated ascending and descending axonal fiber tracts that connects the cerebral cortex to the brain stem and spinal cord" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Islr2tm1.1Ddg/Islr2tm2.1Ddg,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Islr2tm1.1Ddg/Islr2tm2.1Ddg,Tg(mI56i-cre,EGFP)1Kc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL

 MP:0008129 absent brain internal capsule "absence of the area of white matter in the brain that lies between the lenticular and caudate nuclei, and contains a group of myelinated ascending and descending axonal fiber tracts that connects the cerebral cortex to the brain stem and spinal cord" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Islr2tm1.1Ddg/Islr2tm1.1Ddg
Genetic Background: involves: 129S6/SvEvTac

 MP:0008415 abnormal neurite morphology "any structural anomaly of a neuronal process, either a dendrite or an axon in vivo, or a filamentous projection from a neuron such as is seen in tissue culture" [PMID:12951572]
Show

Allelic Composition: Islr2tm1.1Ddg/Islr2tm1.1Ddg
Genetic Background: involves: 129S6/SvEvTac * BALB/cJ * C57BL/6

 MP:0008948 decreased neuron number "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
Show

Allelic Composition: Islr2tm1.1Ddg/Islr2tm1.1Ddg
Genetic Background: involves: 129S6/SvEvTac * BALB/cJ * C57BL/6

 MP:0009970 increased hippocampus pyramidal cell number "increased number of the projection neurons in the pyramidal layer of the hippocampus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Islr2tm1.1Ddg/Islr2tm1.1Ddg
Genetic Background: involves: 129S6/SvEvTac

 MP:0012484 decreased corticospinal tract size "reduced size of the corticospinal fibers that arise from the pyramidal cells within the cerebral cortex layer V of the precentral motor area, the premotor area and the postcentral gyrus, then descend into and through the medulla to form the lateral corticospinal tract and the anterior corticospinal tract" [ISBN:0-683-40008-8]
Show

Allelic Composition: Islr2tm1.1Ddg/Islr2tm2.1Ddg,Tg(mI56i-cre,EGFP)1Kc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr