ENSMUSG00000051965


Mus musculus
maleNanos2cellbindingregulationmrnagermzinccatabolicprocesstranslationspermatogenesiscytoplasmiondecreasednanosxcatfingernanos-typemulticellularorganismdevelopmentdifferentiationgerm-linestempopulationmaintenancemeioticnucleardivisionnuclear-transcribed

Features
Gene ID: ENSMUSG00000051965
  
Biological name :Nanos2
  
Synonyms : Nanos2 / Nanos homolog 2 / P60322
  
Possible biological names infered from orthology : nanos C2HC-type zinc finger 2 / P60321
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: A3
Gene start: 18987400
Gene end: 18988962
  
Corresponding Affymetrix probe sets: 10550519 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000069765
NCBI entrez gene - 378430     See in Manteia.
MGI - MGI:2676627
RefSeq - NM_194064
RefSeq Peptide - NP_918953
swissprot - I6ZHM2
swissprot - P60322
Ensembl - ENSMUSG00000051965
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nanos2ENSDARG00000116802Danio rerio
 NANOS2ENSG00000188425Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nanos3 / P60324 / Mus musculus nanos C2HC-type zinc finger 3 (Nanos3), transcript variant 2, mRNA. / P60323* / nanos C2HC-type zinc finger 3*ENSMUSG0000005615540
Nanos1 / Q80WY3 / Nanos homolog 1 / Q8WY41* / nanos C2HC-type zinc finger 1*ENSMUSG0000007243734


Protein motifs (from Interpro)
Interpro ID Name
 IPR008705  Nanos/Xcat2
 IPR024161  Zinc finger, nanos-type


Gene Ontology (GO)
nitrogen compound metabolic processcatabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processbiosynthetic processanatomical structure developmentmulticellular organism reproductioncellular developmental processmaintenance of cell numbercellular component organizationcell cyclenitrogen compound metabolic processcatabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processbiosynthetic processanatomical structure developmentmulticellular organism reproductioncellular developmental processmaintenance of cell numbercellular component organizationcell cyclenitrogen compound metabolic processcatabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processbiosynthetic processanatomical structure developmentmulticellular organism reproductioncellular developmental processmaintenance of cell numbercellular component organizationcell cyclenitrogen compound metabolic processcatabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processbiosynthetic processanatomical structure developmentmulticellular organism reproductioncellular developmental processmaintenance of cell numbercellular component organizationcell cyclenitrogen compound metabolic processcatabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processbiosynthetic processanatomical structure developmentmulticellular organism reproductioncellular developmental processmaintenance of cell numbercellular component organizationcell cyclenitrogen compound metabolic processcatabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processbiosynthetic processanatomical structure developmentmulticellular organism reproductioncellular developmental processmaintenance of cell numbercellular component organizationcell cyclenitrogen compound metabolic processcatabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processbiosynthetic processanatomical structure developmentmulticellular organism reproductioncellular developmental processmaintenance of cell numbercellular component organizationcell cyclenitrogen compound metabolic processcatabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processbiosynthetic processanatomical structure developmentmulticellular organism reproductioncellular developmental processmaintenance of cell numbercellular component organizationcell cyclenitrogen compound metabolic processcatabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processbiosynthetic processanatomical structure developmentmulticellular organism reproductioncellular developmental processmaintenance of cell numbercellular component organizationcell cyclenitrogen compound metabolic processcatabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processbiosynthetic processanatomical structure developmentmulticellular organism reproductioncellular developmental processmaintenance of cell numbercellular component organizationcell cyclenitrogen conitrogen compound metabolic processcatabolic pcatabolic processcellular mecellular metabolic processprimary metprimary metabolic processorganic suborganic substance metabolic processbiosynthetibiosynthetic processanatomical anatomical structure developmentmulticellulmulticellular organism reproductioncellular decellular developmental processmaintenancemaintenance of cell numbercellular cocellular component organizationcell cyclecell cycle
organic cyclic compound bindingheterocyclic compound bindingprotein bindingion bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingion bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingion bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingion bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingion bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingion bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingion bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingion bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingion bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingion bindingorganic cyclic compound bindingorganic cyclic compound bindingheterocyclic compound bindingheterocyclic compound bindingprotein bindingprotein bindingion bindingion binding
cellprotein-containing complexorganellecellprotein-containing complexorganellecellprotein-containing complexorganellecellprotein-containing complexorganellecellprotein-containing complexorganellecellprotein-containing complexorganellecellprotein-containing complexorganellecellprotein-containing complexorganellecellprotein-containing complexorganellecellprotein-containing complexorganellecellcellprotein-containing complexprotein-containing complexorganelleorganelle
TypeGO IDTermEv.Code
 biological_processGO:0006402 mRNA catabolic process IMP
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0017148 negative regulation of translation IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030718 germ-line stem cell population maintenance IMP
 biological_processGO:0045835 negative regulation of meiotic nuclear division IMP
 biological_processGO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ISO
 cellular_componentGO:0000932 P-body IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISS
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003729 mRNA binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
reproductive system phenotypeendocrine/exocrine gland phenotypecellular phenotypereproductive system phenotypeendocrine/exocrine gland phenotypecellular phenotypereproductive system phenotypeendocrine/exocrine gland phenotypecellular phenotypereproductive system phenotypeendocrine/exocrine gland phenotypecellular phenotypereproductive system phenotypeendocrine/exocrine gland phenotypecellular phenotypereproductive system phenotypeendocrine/exocrine gland phenotypecellular phenotypereproductive system phenotypeendocrine/exocrine gland phenotypecellular phenotypereproductive system phenotypeendocrine/exocrine gland phenotypecellular phenotypereproductive system phenotypeendocrine/exocrine gland phenotypecellular phenotypereproductive system phenotypeendocrine/exocrine gland phenotypecellular phenotypereproductive system phenotypereproductive system phenotypeendocrine/exocrine gland phenotypeendocrine/exocrine gland phenotypecellular phenotypecellular phenotype
IDPhenotypeDefinition Genetic BG
 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Cdh23v/Cdh23+,Myo7ash1/Myo7a+
Genetic Background: involves: BALB

Allelic Composition: Nanos2tm1Ysa/Nanos2tm3Ysa
Genetic Background: involves: 129 * C57BL/6 * CBA * ICR

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Ubr2tm1Ytkw/Ubr2tm1Ytkw
Genetic Background: involves: 129S1/Sv

 MP:0001929 abnormal gametogenesis "defective formation or differentiation of germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:42324]
Show

Allelic Composition: Ltatm1Dch/Ltatm1Dch,Tg(Igk-Lta/Ltb)4Cys/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * DBA/2J

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Nanos2tm1Ysa/Nanos2tm1Ysa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdh23v/Cdh23+,Myo7ash1/Myo7a+
Genetic Background: involves: BALB

Allelic Composition: Nanos2tm1Ysa/Nanos2tm3Ysa
Genetic Background: involves: 129 * C57BL/6 * CBA * ICR

 MP:0003698 abnormal male reproductive system physiology "anomaly in the function of the male organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nanos2tm1Ysa/Nanos2tm1Ysa,Stra8tm1Ysa/Stra8tm1Ysa
Genetic Background: involves: 129 * C57BL/6NCrlj * CBA/JNCrlj * Jcl:MCH(ICR)

Allelic Composition: Nanos2tm1Ysa/Nanos2tm1Ysa,Stra8tm1Ysa/Stra8+
Genetic Background: involves: 129 * C57BL/6NCrlj * CBA/JNCrlj * Jcl:MCH(ICR)

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ubr2tm1Ytkw/Ubr2tm1Ytkw
Genetic Background: involves: 129S1/Sv

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdh23v/Cdh23+,Myo7ash1/Myo7a+
Genetic Background: involves: BALB

Allelic Composition: Nanos2tm1Ysa/Nanos2tm3Ysa
Genetic Background: involves: 129 * C57BL/6 * CBA * ICR

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ubr2tm1Ytkw/Ubr2tm1Ytkw
Genetic Background: involves: 129S1/Sv

Allelic Composition: Nanos2tm1Ysa/Nanos2tm1Ysa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Baxtm1Sjk/Bax+,Nanos2tm1Ysa/Nanos2tm1Ysa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Nanos2tm1Ysa/Nanos2tm1Ysa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005169 abnormal male meiosis "malfunction in the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nanos2tm1Ysa/Nanos2tm1Ysa,Stra8tm1Ysa/Stra8tm1Ysa
Genetic Background: involves: 129 * C57BL/6NCrlj * CBA/JNCrlj * Jcl:MCH(ICR)

Allelic Composition: Nanos2tm1Ysa/Nanos2tm1Ysa,Stra8tm1Ysa/Stra8+
Genetic Background: involves: 129 * C57BL/6NCrlj * CBA/JNCrlj * Jcl:MCH(ICR)

 MP:0006362 abnormal male germ cell morphology "any structural anomaly of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nanos2tm1Ysa/Nanos2tm1Ysa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Baxtm1Sjk/Bax+,Nanos2tm1Ysa/Nanos2tm1Ysa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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