ENSMUSG00000052212


Mus musculus

Features
Gene ID: ENSMUSG00000052212
  
Biological name :Cd177
  
Synonyms : Cd177 / CD177 antigen / Q8R2S8
  
Possible biological names infered from orthology : CD177 molecule / Q8N6Q3
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: A3
Gene start: 24743983
Gene end: 24760311
  
Corresponding Affymetrix probe sets: 10560886 (MoGene1.0st)   1424509_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000064934
NCBI entrez gene - 68891     See in Manteia.
MGI - MGI:1916141
RefSeq - XM_017312278
RefSeq - NM_026862
RefSeq - XM_011250688
RefSeq - XM_011250689
RefSeq Peptide - NP_081138
swissprot - Q8R2S8
Ensembl - ENSMUSG00000052212
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CD177ENSG00000204936Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
BC049730 / cDNA sequence BC049730ENSMUSG000000455879
Gm4763ENSMUSG000000587179
Q9JMI7 / Tex101 / testis expressed gene 101 / Q9BY14* / testis expressed 101*ENSMUSG000000627738
Lypd4 / Q8BVP6 / Ly6/PLAUR domain-containing protein 4 / Q6UWN0* / LY6/PLAUR domain containing 4*ENSMUSG000000627327


Protein motifs (from Interpro)
Interpro ID Name
 IPR016054  Ly-6 antigen/uPA receptor-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0007155 cell adhesion ISO
 biological_processGO:0007159 leukocyte cell-cell adhesion ISO
 biological_processGO:0030100 regulation of endocytosis ISO
 biological_processGO:0032930 positive regulation of superoxide anion generation ISO
 biological_processGO:0034394 protein localization to cell surface ISO
 biological_processGO:0043315 positive regulation of neutrophil degranulation ISO
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045217 cell-cell junction maintenance ISO
 biological_processGO:0072672 neutrophil extravasation ISO
 biological_processGO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules ISO
 biological_processGO:2001044 regulation of integrin-mediated signaling pathway ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030667 secretory granule membrane ISO
 cellular_componentGO:0044853 plasma membrane raft ISO
 cellular_componentGO:0070821 tertiary granule membrane ISO
 molecular_functionGO:0002020 protease binding ISO
 molecular_functionGO:0005178 integrin binding ISO
 molecular_functionGO:0048306 calcium-dependent protein binding ISO


Pathways (from Reactome)
Pathway description
Common Pathway of Fibrin Clot Formation
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Arhgap28tm2b(KOMP)Wtsi/Arhgap28tm2b(KOMP)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0000223 decreased monocyte count "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Arhgap28tm2b(KOMP)Wtsi/Arhgap28tm2b(KOMP)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Arhgap28tm2b(KOMP)Wtsi/Arhgap28tm2b(KOMP)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000057729 Prtn3 / proteinase 3 / P24158*  / complex
 ENSMUSG00000027611 Procr / Q64695 / protein C receptor, endothelial / Q9UNN8* / protein C receptor*  / complex / reaction






 

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