ENSMUSG00000057729


Mus musculus

Features
Gene ID: ENSMUSG00000057729
  
Biological name :Prtn3
  
Synonyms : proteinase 3 / Prtn3
  
Possible biological names infered from orthology : P24158
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: C1
Gene start: 79874476
Gene end: 79883174
  
Corresponding Affymetrix probe sets: 10364529 (MoGene1.0st)   1419669_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000006679
Ensembl peptide - ENSMUSP00000129585
NCBI entrez gene - 19152     See in Manteia.
MGI - MGI:893580
RefSeq - NM_011178
RefSeq Peptide - NP_035308
swissprot - F6ZK01
swissprot - A0A0R4IZY6
Ensembl - ENSMUSG00000057729
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PRTN3ENSG00000196415Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Elane / Q3UP87 / Neutrophil elastase / P08246* / elastase, neutrophil expressed*ENSMUSG0000002012552


Protein motifs (from Interpro)
Interpro ID Name
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR009003  Peptidase S1, PA clan
 IPR018114  Serine proteases, trypsin family, histidine active site
 IPR033116  Serine proteases, trypsin family, serine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006509 membrane protein ectodomain proteolysis IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0045217 cell-cell junction maintenance IEA
 biological_processGO:0050765 negative regulation of phagocytosis IEA
 biological_processGO:0072672 neutrophil extravasation IEA
 biological_processGO:0097029 mature conventional dendritic cell differentiation IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 cellular_componentGO:0035578 azurophil granule lumen IEA
 cellular_componentGO:0044853 plasma membrane raft IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA


Pathways (from Reactome)
Pathway description
Common Pathway of Fibrin Clot Formation
Neutrophil degranulation
Antimicrobial peptides


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dicer1tm1.1Doca/Dicer1tm1.1Doca
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dicer1tm1.1Doca/Dicer1tm1.1Doca
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0006043 decreased apoptosis "less than normal cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Dicer1tm1.1Doca/Dicer1tm1.1Doca
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000052212 Cd177 / Q8R2S8 / CD177 antigen / Q8N6Q3* / CD177 molecule*  / complex
 ENSMUSG00000027611 Procr / Q64695 / protein C receptor, endothelial / Q9UNN8* / protein C receptor*  / complex / reaction






 

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