ENSMUSG00000052726


Mus musculus

Features
Gene ID: ENSMUSG00000052726
  
Biological name :Kcnt2
  
Synonyms : Kcnt2 / potassium sodium-activated channel subfamily T member 2
  
Possible biological names infered from orthology : Q6UVM3
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: F
Gene start: 140246158
Gene end: 140612067
  
Corresponding Affymetrix probe sets: 10350438 (MoGene1.0st)   1459971_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000113333
Ensembl peptide - ENSMUSP00000141947
Ensembl peptide - ENSMUSP00000113535
Ensembl peptide - ENSMUSP00000112887
NCBI entrez gene - 240776     See in Manteia.
MGI - MGI:3036273
RefSeq - XM_017320510
RefSeq - XM_011247999
RefSeq - XM_017320506
RefSeq - XM_017320507
RefSeq - XM_017320508
RefSeq - XM_017320509
RefSeq - NM_001081027
RefSeq - XM_006529562
RefSeq - XM_006529565
RefSeq - XM_006529566
RefSeq - XM_006529567
RefSeq - XM_006529572
RefSeq - XM_011247996
RefSeq - XM_011247997
RefSeq - XM_011247998
RefSeq Peptide - NP_001074496
swissprot - D3Z649
swissprot - D3Z592
swissprot - D3YTU6
swissprot - A0A0A6YXD8
Ensembl - ENSMUSG00000052726
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kcnt2ENSDARG00000075812Danio rerio
 KCNT2ENSGALG00000041680Gallus gallus
 KCNT2ENSG00000162687Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kcnt1 / Q6ZPR4 / Potassium channel subfamily T member 1 / Q5JUK3* / potassium sodium-activated channel subfamily T member 1*ENSMUSG0000005874076
Kcnma1 / potassium large conductance calcium-activated channel, subfamily M, alpha member 1 / Q12791* / potassium calcium-activated channel subfamily M alpha 1*ENSMUSG0000006314219
Kcnu1 / A8MYU2* / potassium calcium-activated channel subfamily U member 1*ENSMUSG0000003157618


Protein motifs (from Interpro)
Interpro ID Name
 IPR003929  Potassium channel, BK, alpha subunit
 IPR013099  Potassium channel domain
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006813 potassium ion transport ISO
 biological_processGO:0071805 potassium ion transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0008076 voltage-gated potassium channel complex IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005249 voltage-gated potassium channel activity IBA
 molecular_functionGO:0005267 potassium channel activity ISO
 molecular_functionGO:0015269 calcium-activated potassium channel activity IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Wdr13tm1Kuma/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0003488 decreased channel response intensity 
Show

Allelic Composition: Kcnt1tm1.2Clin/Kcnt1tm1.2Clin,Kcnt2tm1.2Clin/Kcnt2tm1.2Clin
Genetic Background: B6.Cg-Kcnt2tm1.2Clin Kcnt1tm1.2Clin

 MP:0003998 decreased thermal nociceptive threshold "a lower than average point at which thermal pain sensation is first detectable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Kcnt1tm1.2Clin/Kcnt1tm1.2Clin,Kcnt2tm1.2Clin/Kcnt2tm1.2Clin
Genetic Background: B6.Cg-Kcnt2tm1.2Clin Kcnt1tm1.2Clin

 MP:0005402 abnormal action potential "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kcnt1tm1.2Clin/Kcnt1+
Genetic Background: B6.Cg-Kcnt1tm1.2Clin

 MP:0008532 decreased chemical nociceptive threshold "a lower than average concentration at which chemically induced pain sensation is first detectable" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kcnt1tm1.2Clin/Kcnt1tm1.2Clin,Kcnt2tm1.2Clin/Kcnt2tm1.2Clin
Genetic Background: B6.Cg-Kcnt2tm1.2Clin Kcnt1tm1.2Clin

 MP:0010072 increased pruritus "abnormal presence or increased intensity of an uncomfortable sensation resulting from irritation of the skin or mucous membranes that evokes the desire or reflex to rub or scratch" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Kcnt1tm1.2Clin/Kcnt1tm1.2Clin,Kcnt2tm1.2Clin/Kcnt2tm1.2Clin
Genetic Background: B6.Cg-Kcnt2tm1.2Clin Kcnt1tm1.2Clin

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr