ENSMUSG00000031576


Mus musculus

Features
Gene ID: ENSMUSG00000031576
  
Biological name :Kcnu1
  
Synonyms : Kcnu1
  
Possible biological names infered from orthology : A8MYU2 / potassium calcium-activated channel subfamily U member 1
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: A2
Gene start: 25849623
Gene end: 25937939
  
Corresponding Affymetrix probe sets: 10571065 (MoGene1.0st)   1422838_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000113442
Ensembl peptide - ENSMUSP00000123273
Ensembl peptide - ENSMUSP00000096457
NCBI entrez gene - 16532     See in Manteia.
MGI - MGI:1202300
RefSeq - XM_017312584
RefSeq - XM_006509024
RefSeq - XM_017312581
RefSeq - XM_017312582
RefSeq - XM_017312583
RefSeq - NM_008432
RefSeq Peptide - NP_032458
swissprot - G3X9P7
swissprot - D3Z073
swissprot - D3Z5P2
Ensembl - ENSMUSG00000031576
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 KCNU1ENSGALG00000045668Gallus gallus
 KCNU1ENSG00000215262Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kcnma1 / potassium large conductance calcium-activated channel, subfamily M, alpha member 1 / Q12791* / potassium calcium-activated channel subfamily M alpha 1*ENSMUSG0000006314241
Kcnt2 / potassium sodium-activated channel subfamily T member 2 / Q6UVM3*ENSMUSG0000005272618
Kcnt1 / Q6ZPR4 / Potassium channel subfamily T member 1 / Q5JUK3* / potassium sodium-activated channel subfamily T member 1*ENSMUSG0000005874018


Protein motifs (from Interpro)
Interpro ID Name
 IPR003929  Potassium channel, BK, alpha subunit
 IPR005821  Ion transport domain
 IPR028325  Voltage-gated potassium channel


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0071805 potassium ion transmembrane transport IEA
 cellular_componentGO:0008076 voltage-gated potassium channel complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005249 voltage-gated potassium channel activity IEA
 molecular_functionGO:0005267 potassium channel activity IEA


Pathways (from Reactome)
Pathway description
Sperm Motility And Taxes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000242 impaired fertilization "defect or reduced ability in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn
Genetic Background: Not Specified

Allelic Composition: Kcnu1tm1.2Clin/Kcnu1tm1.2Clin
Genetic Background: B6.Cg-Kcnu1tm1.2Clin

Allelic Composition: Kcnu1tm1.2Clin/Kcnu1tm1.2Clin
Genetic Background: involves: C57BL/6NTac

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn
Genetic Background: Not Specified

Allelic Composition: Kcnu1tm1.2Clin/Kcnu1tm1.2Clin
Genetic Background: B6.Cg-Kcnu1tm1.2Clin

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn
Genetic Background: Not Specified

Allelic Composition: Kcnu1tm1.2Clin/Kcnu1tm1.2Clin
Genetic Background: B6.Cg-Kcnu1tm1.2Clin

 MP:0003666 impaired sperm capacitation "anomaly in the change undergone by spermatozoa in the female genital tract that enables them to penetrate and fertilize an egg" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96669]
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Allelic Composition: Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn
Genetic Background: Not Specified

 MP:0004542 impaired acrosome reaction "abnormality in the cellular exocytosis that allows sperm to penetrate the zona pellucida of ovulated eggs" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn
Genetic Background: Not Specified

 MP:0004543 abnormal sperm physiology "anomaly in the normal function of spermatozoa" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Plagl1Gt(OST181461)Lex/Plagl1Gt(OST181461)Lex
Genetic Background: involves: 129S5/SvEvBrd

Allelic Composition: Kcnu1tm1.2Clin/Kcnu1tm1.2Clin
Genetic Background: B6.Cg-Kcnu1tm1.2Clin

Allelic Composition: Kcnu1tm1.2Clin/Kcnu1+
Genetic Background: B6.Cg-Kcnu1tm1.2Clin

Allelic Composition: Kcnu1tm1.2Clin/Kcnu1tm1.2Clin
Genetic Background: involves: C57BL/6NTac

Allelic Composition: Kcnu1tm1.1Clin/Kcnu1+
Genetic Background: involves: C57BL/6NTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031576 Kcnu1 / A8MYU2* / potassium calcium-activated channel subfamily U member 1*  / complex






 

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