ENSMUSG00000053025


Mus musculus

Features
Gene ID: ENSMUSG00000053025
  
Biological name :Sv2b
  
Synonyms : Q8BG39 / Sv2b / Synaptic vesicle glycoprotein 2B
  
Possible biological names infered from orthology : Q7L1I2
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: D1
Gene start: 75114894
Gene end: 75309262
  
Corresponding Affymetrix probe sets: 10564646 (MoGene1.0st)   1434800_at (Mouse Genome 430 2.0 Array)   1435687_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000082254
Ensembl peptide - ENSMUSP00000127245
Ensembl peptide - ENSMUSP00000146049
Ensembl peptide - ENSMUSP00000146277
NCBI entrez gene - 64176     See in Manteia.
MGI - MGI:1927338
RefSeq - XM_017312212
RefSeq - NM_001109753
RefSeq - NM_153579
RefSeq - XM_006541059
RefSeq - XM_006541060
RefSeq - XM_006541061
RefSeq - XM_017312210
RefSeq Peptide - NP_001103223
RefSeq Peptide - NP_705807
swissprot - Q8BG39
swissprot - A0A0U1RQ76
Ensembl - ENSMUSG00000053025
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sv2baENSDARG00000057427Danio rerio
 sv2bbENSDARG00000060711Danio rerio
 SV2BENSGALG00000030250Gallus gallus
 SV2BENSG00000185518Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sv2a / Q9JIS5 / Synaptic vesicle glycoprotein 2A / Q7L0J3*ENSMUSG0000003848665
Sv2c / Q69ZS6 / synaptic vesicle glycoprotein 2c / Q496J9*ENSMUSG0000005111161
Svop / Q8BFT9 / Synaptic vesicle 2-related protein / Q8N4V2* / SV2 related protein*ENSMUSG0000004207819
Svopl / Q6PDF3 / Putative transporter SVOPL / Q8N434* / SVOP like*ENSMUSG0000002983017


Protein motifs (from Interpro)
Interpro ID Name
 IPR001646  Pentapeptide repeat
 IPR005828  Major facilitator, sugar transporter-like
 IPR005829  Sugar transporter, conserved site
 IPR011701  Major facilitator superfamily
 IPR020846  Major facilitator superfamily domain
 IPR022308  Synaptic vesicle protein SV2
 IPR036259  MFS transporter superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006836 neurotransmitter transport IEA
 biological_processGO:0007268 chemical synaptic transmission TAS
 biological_processGO:0055085 transmembrane transport IEA
 cellular_componentGO:0001669 acrosomal vesicle IEA
 cellular_componentGO:0008021 synaptic vesicle IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030672 synaptic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0005215 transporter activity IEA
 molecular_functionGO:0022857 transmembrane transporter activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Sv2btm1Baj/Sv2btm1Baj
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Sv2atm1Baj/Sv2atm1Baj,Sv2btm1Baj/Sv2btm1Baj
Genetic Background: involves: 129 * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sv2atm1Baj/Sv2atm1Baj,Sv2btm1Baj/Sv2btm1Baj,Svoptm1.1Baj/Svoptm1.1Baj
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6Ncr

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sv2atm1Sud/Sv2atm1Sud
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sv2btm1Baj/Sv2btm1Baj
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Sv2atm1Baj/Sv2atm1Baj,Sv2btm1Baj/Sv2btm1Baj
Genetic Background: involves: 129 * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sv2atm1Sud/Sv2atm1Sud
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sv2btm1Sud/Sv2btm1Sud
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002917 decreased synaptic depression "decrease in the duration of the reduction of effectiveness of synaptic connections between neurons and target after repetitive stimulation" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Sv2atm1Sud/Sv2atm1Sud,Sv2btm1Sud/Sv2btm1Sud
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004021 abnormal rod electrophysiology "anomaly in the function of dark adapted vision mediated by the rods" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Sv2btm1Baj/Sv2btm1Baj
Genetic Background: involves: 129 * C57BL/6

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sv2atm1Baj/Sv2atm1Baj,Sv2btm1Baj/Sv2btm1Baj
Genetic Background: involves: 129 * C57BL/6

 MP:0006069 abnormal retinal neuronal layer morphology "malformation in any of the neuronal layers that make up the retina, including the ganglion cell, inner plexiform, inner nuclear, outer plexiform, outer nuclear layers, the inner and outer segments" [smb:Susan M Bello, Mouse Genome Informatics Curator, Gray s Anatomy:ISBN 0-914294-08-3]
Show

Allelic Composition: Sv2btm1Baj/Sv2btm1Baj
Genetic Background: involves: 129 * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Sv2atm1Sud/Sv2atm1Sud,Sv2btm1Sud/Sv2btm1Sud
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sv2atm1Baj/Sv2atm1Baj,Sv2btm1Baj/Sv2btm1Baj,Svoptm1.1Baj/Svoptm1.1Baj
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6Ncr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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