ENSMUSG00000055561


Mus musculus

Features
Gene ID: ENSMUSG00000055561
  
Biological name :Spink5
  
Synonyms : serine peptidase inhibitor, Kazal type 5 / Spink5
  
Possible biological names infered from orthology : Q9NQ38
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: B3
Gene start: 43963235
Gene end: 44022501
  
Corresponding Affymetrix probe sets: 10455395 (MoGene1.0st)   1430567_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000066214
NCBI entrez gene - 72432     See in Manteia.
MGI - MGI:1919682
RefSeq - XM_006526280
RefSeq - NM_001081180
RefSeq - XM_006526279
RefSeq Peptide - NP_001074649
swissprot - Q148R4
Ensembl - ENSMUSG00000055561
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000045520Gallus gallus
 SPIK5ENSGALG00000031496Gallus gallus
 SPIK7ENSGALG00000003512Gallus gallus
 Q9NQ38ENSG00000133710Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002350  Kazal domain
 IPR036058  Kazal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002787 negative regulation of antibacterial peptide production IMP
 biological_processGO:0009913 epidermal cell differentiation IEA
 biological_processGO:0030155 regulation of cell adhesion IMP
 biological_processGO:0045861 negative regulation of proteolysis IMP
 biological_processGO:1900004 negative regulation of serine-type endopeptidase activity IMP
 biological_processGO:1902572 negative regulation of serine-type peptidase activity IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0097209 epidermal lamellar body IEA
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0030414 peptidase inhibitor activity IMP


Pathways (from Reactome)
Pathway description
Formation of the cornified envelope


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Spink5m1Btlr/Spink5m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0000377 abnormal hair follicle "malformed invagination of the epidermis from which the hair shaft develops" [J:65031]
Show

Allelic Composition: Zfp384tm1Tnk/Zfp384+
Genetic Background: involves: C57BL/6 * CBA

 MP:0001190 reddish skin "skin has a more intense ruddy appearance than normal, often due to capillary congestion" [J:65038]
Show

Allelic Composition: Spink5tm1Hov/Spink5tm1Hov
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0001192 scaly skin "skin covered with shedding scales or flakes" [J:65146]
Show

Allelic Composition: Spink5tm1Hov/Spink5tm1Hov
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Spink5m1Btlr/Spink5m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0001195 flaky skin "shedding scales on the skin " [J:56641]
Show

Allelic Composition: Mtss1tm1Pla/Mtss1tm1Pla,Ptch1tm1Mps/Ptch1tm1Mps
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001208 blistering "accumulation of fluid- filled thin walled structures under the epidermis or within the epidermis" [J:65039]
Show

Allelic Composition: Spink5Tn(Pgk2-sb10,sb-Tyr)1498Ove/Spink5Tn(Pgk2-sb10,sb-Tyr)1498Ove
Genetic Background: involves: FVB/N

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
Show

Allelic Composition: Spink5tm1Hov/Spink5tm1Hov
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Spink5m1Btlr/Spink5m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Il23atm1Dnax/Il23atm1Dnax
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Spink5tm1Hov/Spink5tm1Hov
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0001230 epidermal desquamation "shedding of the cuticle of the epidermis in scales or shreds" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:56777]
Show

Allelic Composition: Spink5tm1Hov/Spink5tm1Hov
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0001239 abnormal granular layer morphology "structural or developmental anomaly of the layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Spink5tm1Hov/Spink5tm1Hov
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Spink5Tn(Pgk2-sb10,sb-Tyr)1498Ove/Spink5Tn(Pgk2-sb10,sb-Tyr)1498Ove
Genetic Background: involves: FVB/N

 MP:0001240 abnormal cornified layer morphology "structural or developmental anomaly of the outer layer of the epidermis, consisting of several layers of flat keratinized non-nucleated cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Spink5tm1Hov/Spink5tm1Hov
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Spink5Tn(Pgk2-sb10,sb-Tyr)1498Ove/Spink5Tn(Pgk2-sb10,sb-Tyr)1498Ove
Genetic Background: involves: FVB/N

Allelic Composition: F2rl1tm1Cgh/F2rl1tm1Cgh,Spink5tm1Hov/Spink5tm1Hov
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
Show

Allelic Composition: Il23atm1Dnax/Il23atm1Dnax
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Spink5tm1Hov/Spink5tm1Hov
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0001283 sparse vibrissae "few and widely spaced whiskers" [J:65302]
Show

Allelic Composition: Spink5tm1Hov/Spink5tm1Hov
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0001429 dehydration "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]
Show

Allelic Composition: Il23atm1Dnax/Il23atm1Dnax
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Spink5Tn(Pgk2-sb10,sb-Tyr)1498Ove/Spink5Tn(Pgk2-sb10,sb-Tyr)1498Ove
Genetic Background: involves: FVB/N

Allelic Composition: F2rl1tm1Cgh/F2rl1tm1Cgh,Spink5tm1Hov/Spink5tm1Hov
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0001874 acanthosis "diffuse hyperplasia of the spinous layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Spink5tm1Hov/Spink5tm1Hov
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: F2rl1tm1Cgh/F2rl1tm1Cgh,Spink5tm1Hov/Spink5tm1Hov
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0002060 abnormal skin morphology "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]
Show

Allelic Composition: Acanb2b183Clo/Acanb2b183Clo
Genetic Background: C57BL/6J-Acanb2b183Clo

 MP:0002098 abnormal vibrissae morphology "irregular or unusual structure, appearance, or alignment of the vibrissae" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Zfp384tm1Tnk/Zfp384+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: F2rl1tm1Cgh/F2rl1tm1Cgh,Spink5tm1Hov/Spink5tm1Hov
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0002796 impaired skin barrier function "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]
Show

Allelic Composition: Il23atm1Dnax/Il23atm1Dnax
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Spink5tm1Hov/Spink5tm1Hov
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Spink5Tn(Pgk2-sb10,sb-Tyr)1498Ove/Spink5Tn(Pgk2-sb10,sb-Tyr)1498Ove
Genetic Background: involves: FVB/N

 MP:0003089 reduced skin tensile strength "reduction in the normal maximum tension the skin can withstand without tearing" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:48068]
Show

Allelic Composition: Spink5tm1Hov/Spink5tm1Hov
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0003427 parakeratosis "abnormal retention of the nuclei of the keratinocytes in the stratum corneum of the epidermis" [smb:Susan M Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Spink5tm1Hov/Spink5tm1Hov
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0003809 abnormal hair shaft morphology "irregular or unusual structure of the cuticle, and/or cortex and/or medulla of a hair" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Spink5tm1Hov/Spink5tm1Hov
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0009594 abnormal corneocyte envelope morphology "any structural or developmental anomaly of the electron-dense layer of highly transglutaminase cross-linked protein that is deposited on the inner surface of the plasma membrane of corneocytes in the outermost layers of the epidermis; a monomolecular layer of ceramides is covalently attached to the outer surface of the CE to form a hydrophobic lipid envelope that covers each corneocyte and provides continuity with the lipid matrix" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il23atm1Dnax/Il23atm1Dnax
Genetic Background: involves: 129 * C57BL/6

 MP:0010234 abnormal vibrissa follicle morphology "any structural anomaly of one of the tubular invaginations of the epidermis enclosing the hair roots and from which grow the vibrissae located on the muzzle and face of many species" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Spink5tm1Hov/Spink5tm1Hov
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Il23atm1Dnax/Il23atm1Dnax
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Spink5tm1Hov/Spink5tm1Hov
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Spink5Tn(Pgk2-sb10,sb-Tyr)1498Ove/Spink5Tn(Pgk2-sb10,sb-Tyr)1498Ove
Genetic Background: involves: FVB/N

Allelic Composition: F2rl1tm1Cgh/F2rl1tm1Cgh,Spink5tm1Hov/Spink5tm1Hov
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000074155 Klk5 / kallikrein related-peptidase 5 / Q9Y337*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr