ENSMUSG00000056370


Mus musculus

Features
Gene ID: ENSMUSG00000056370
  
Biological name :Sftpb
  
Synonyms : Sftpb / surfactant associated protein B
  
Possible biological names infered from orthology : P07988 / surfactant protein B
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: C1
Gene start: 72304610
Gene end: 72314371
  
Corresponding Affymetrix probe sets: 10539091 (MoGene1.0st)   1437028_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000066805
Ensembl peptide - ENSMUSP00000138204
Ensembl peptide - ENSMUSP00000138485
Ensembl peptide - ENSMUSP00000138695
NCBI entrez gene - 20388     See in Manteia.
MGI - MGI:109516
RefSeq - NM_147779
RefSeq - NM_001282071
RefSeq Peptide - NP_001269000
RefSeq Peptide - NP_680088
swissprot - S4R2L6
swissprot - S4R239
swissprot - F8WGK6
Ensembl - ENSMUSG00000056370
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sftpbaENSDARG00000094708Danio rerio
 sftpbbENSDARG00000067566Danio rerio
 SFTPBENSG00000168878Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Psap / Q61207 / prosaposin / P07602*ENSMUSG0000000420724
Psapl1 / prosaposin-like 1 / Q6NUJ1* / prosaposin like 1 (gene/pseudogene)*ENSMUSG0000004343022


Protein motifs (from Interpro)
Interpro ID Name
 IPR003119  Saposin A-type domain
 IPR007856  Saposin-like type B, region 1
 IPR008138  Saposin B type, region 2
 IPR008139  Saposin B type domain
 IPR008373  Saposin
 IPR011001  Saposin-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006665 sphingolipid metabolic process IEA
 cellular_componentGO:0005764 lysosome IEA


Pathways (from Reactome)
Pathway description
Surfactant metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001177 atelectasis "collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Terctm1Rdp/Terctm1Rdp,Terf1tm1Tdl/Terf1tm1Tdl
Genetic Background: involves: 129S2/SvPas

 MP:0001385 pup cannibalization "the killing and eating of newborn mice by the mother; can be a normal response if the mother does not recognize the pups as her own" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Terctm1Rdp/Terctm1Rdp,Terf1tm1Tdl/Terf1tm1Tdl
Genetic Background: involves: 129S2/SvPas

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Terctm1Rdp/Terctm1Rdp,Terf1tm1Tdl/Terf1tm1Tdl
Genetic Background: involves: 129S2/SvPas

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
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Allelic Composition: Terctm1Rdp/Terctm1Rdp,Terf1tm1Tdl/Terf1tm1Tdl
Genetic Background: involves: 129S2/SvPas

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Terctm1Rdp/Terctm1Rdp,Terf1tm1Tdl/Terf1tm1Tdl
Genetic Background: involves: 129S2/SvPas

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Terctm1Rdp/Terctm1Rdp,Terf1tm1Tdl/Terf1tm1Tdl
Genetic Background: involves: 129S2/SvPas

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Terctm1Rdp/Terctm1Rdp,Terf1tm1Tdl/Terf1tm1Tdl
Genetic Background: involves: 129S2/SvPas

 MP:0002275 abnormal type II pneumocyte morphology "any structural anomaly of the epithelial cells lining the alveoli that produce surfactant " [Pathology , 2nd edition:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Terctm1Rdp/Terctm1Rdp,Terf1tm1Tdl/Terf1tm1Tdl
Genetic Background: involves: 129S2/SvPas

 MP:0004780 abnormal surfactant secretion "anomaly in the production or release from pneumocytes of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Terctm1Rdp/Terctm1Rdp,Terf1tm1Tdl/Terf1tm1Tdl
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Sftpbtm1Jaw/Sftpb+
Genetic Background: involves: 129S2/SvPas

 MP:0004781 abnormal surfactant composition "anomaly in the chemical consituents of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Terctm1Rdp/Terctm1Rdp,Terf1tm1Tdl/Terf1tm1Tdl
Genetic Background: involves: 129S2/SvPas

 MP:0004782 abnormal surfactant physiology "anomaly in the production, composition or function of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Terctm1Rdp/Terctm1Rdp,Terf1tm1Tdl/Terf1tm1Tdl
Genetic Background: involves: 129S2/SvPas

 MP:0005165 increased susceptibility to injury "greater than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Runx2tm1Mjo/Runx2+,Tg(Eno2tTA)#Nes/0,Tg(tetO-Zfp521)#Rbar/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0010814 absent alveolar lamellar bodies "absence of the specialized secretory organelles found in the cytoplasm of type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Terctm1Rdp/Terctm1Rdp,Terf1tm1Tdl/Terf1tm1Tdl
Genetic Background: involves: 129S2/SvPas

 MP:0010896 decreased lung compliance "reduced ability of the lung to distend in response to pressure without disruption, usually expressed as the unit volume of change in the lung per unit of pressure" [ISBN:070202788 "Saunders Comprehensive Veterinary Dictionary, 3rd edition"]
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Allelic Composition: Sftpbtm1Jaw/Sftpb+
Genetic Background: involves: 129S2/SvPas

 MP:0010938 decreased total lung capacity "reduced volume of air contained in the lungs at the end of maximal inspiration" [MGI:csmith]
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Allelic Composition: Sftpbtm1Jaw/Sftpb+
Genetic Background: involves: 129S2/SvPas

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Terctm1Rdp/Terctm1Rdp,Terf1tm1Tdl/Terf1tm1Tdl
Genetic Background: involves: 129S2/SvPas

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002204 Napsa / O09043 / Napsin-A / O96009* / napsin A aspartic peptidase*  / reaction
 ENSMUSG00000032359 Ctsh / P49935 / cathepsin H / P09668*  / reaction
 ENSMUSG00000056370 Sftpb / surfactant associated protein B / P07988* / surfactant protein B*  / complex / reaction






 

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