ENSMUSG00000056966


Mus musculus

Features
Gene ID: ENSMUSG00000056966
  
Biological name :Gjc3
  
Synonyms : gap junction protein, gamma 3 / Gjc3 / Q921C1
  
Possible biological names infered from orthology : Q8NFK1
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: G2
Gene start: 137953461
Gene end: 137963098
  
Corresponding Affymetrix probe sets: 10534960 (MoGene1.0st)   1422042_at (Mouse Genome 430 2.0 Array)   1445523_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000076367
NCBI entrez gene - 118446     See in Manteia.
MGI - MGI:2153041
RefSeq - NM_080450
RefSeq Peptide - NP_536698
swissprot - Q921C1
Ensembl - ENSMUSG00000056966
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GJC3ENSG00000176402Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gjb3 / P28231 / gap junction protein, beta 3 / O75712*ENSMUSG0000004236727
Gjb2 / Q00977 / gap junction protein, beta 2 / P29033*ENSMUSG0000004635227
Gjb1 / P28230 / gap junction protein, beta 1 / P08034*ENSMUSG0000004779727
Gjb6 / P70689 / gap junction protein, beta 6 / O95452*ENSMUSG0000004005526
Gjb4 / Q02738 / gap junction protein, beta 4 / Q9NTQ9*ENSMUSG0000004662325
Gjb5 / Q02739 / gap junction protein, beta 5 / O95377*ENSMUSG0000004235724
Gjd4 / Q8BSD4 / gap junction protein, delta 4 / Q96KN9*ENSMUSG0000003685522


Protein motifs (from Interpro)
Interpro ID Name
 IPR000500  Connexin
 IPR013092  Connexin, N-terminal
 IPR017990  Connexin, conserved site
 IPR019570  Gap junction protein, cysteine-rich domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007154 cell communication IEA
 biological_processGO:0007267 cell-cell signaling ISA
 biological_processGO:0007605 sensory perception of sound IMP
 biological_processGO:0042552 myelination IMP
 biological_processGO:0055085 transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005921 gap junction IEA
 cellular_componentGO:0005922 connexin complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0043209 myelin sheath IDA
 molecular_functionGO:0005243 gap junction channel activity ISA
 molecular_functionGO:0042803 protein homodimerization activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000921 demyelination "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc18a2tm1Uhl/Slc18a2tm1Uhl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004597 increased susceptibility to noise-induced hearing loss "greater than normal reduction in hearing sensitivity following exposure to acute noise that is injurious to the cochlea" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc18a2tm1Uhl/Slc18a2tm1Uhl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0011966 abnormal auditory brainstem response waveform shape "any anomaly in the characteristic pattern of electrical activity recording of a series of vertex positive waves generated by neurons in the ascending auditory system, that can be recorded from scalp electrograms by using computer-averaged responses to short tone bursts" [MGI:csmith]
Show

Allelic Composition: Slc18a2tm1Uhl/Slc18a2tm1Uhl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Slc18a2tm1Uhl/Slc18a2tm1Uhl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr