ENSMUSG00000042367


Mus musculus

Features
Gene ID: ENSMUSG00000042367
  
Biological name :Gjb3
  
Synonyms : gap junction protein, beta 3 / Gjb3 / P28231
  
Possible biological names infered from orthology : O75712
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D2.2
Gene start: 127325235
Gene end: 127330844
  
Corresponding Affymetrix probe sets: 10516484 (MoGene1.0st)   1416715_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000046755
Ensembl peptide - ENSMUSP00000101697
NCBI entrez gene - 14620     See in Manteia.
MGI - MGI:95721
RefSeq - NM_001160012
RefSeq - NM_008126
RefSeq Peptide - NP_001153484
RefSeq Peptide - NP_032152
swissprot - P28231
Ensembl - ENSMUSG00000042367
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cx35.4ENSDARG00000042866Danio rerio
 GJB3ENSGALG00000028424Gallus gallus
 GJB3ENSG00000188910Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gjb4 / Q02738 / gap junction protein, beta 4 / Q9NTQ9*ENSMUSG0000004662356
Gjb5 / Q02739 / gap junction protein, beta 5 / O95377*ENSMUSG0000004235752
Gjb1 / P28230 / gap junction protein, beta 1 / P08034*ENSMUSG0000004779746
Gjb2 / Q00977 / gap junction protein, beta 2 / P29033*ENSMUSG0000004635243
Gjb6 / P70689 / gap junction protein, beta 6 / O95452*ENSMUSG0000004005541
Gjd4 / Q8BSD4 / gap junction protein, delta 4 / Q96KN9*ENSMUSG0000003685529
Gjc3 / Q921C1 / gap junction protein, gamma 3 / Q8NFK1*ENSMUSG0000005696627


Protein motifs (from Interpro)
Interpro ID Name
 IPR000500  Connexin
 IPR002269  Gap junction beta-3 protein (Cx31)
 IPR013092  Connexin, N-terminal
 IPR017990  Connexin, conserved site
 IPR019570  Gap junction protein, cysteine-rich domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0001890 placenta development IMP
 biological_processGO:0007154 cell communication IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0043588 skin development IEA
 biological_processGO:0071300 cellular response to retinoic acid IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0005921 gap junction IEA
 cellular_componentGO:0005922 connexin complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction ISO
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Gap junction assembly


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Folh1tm1b(KOMP)Wtsi/Folh1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Folh1tm1b(KOMP)Wtsi/J

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
Show

Allelic Composition: Tsc2tm1Mjg/Tsc2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
Show

Allelic Composition: Tsc2tm1Mjg/Tsc2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001711 abnormal placenta 
Show

Allelic Composition: Pax6Sey/Pax6+
Genetic Background: B10.Cg-Pax6Sey

 MP:0001726 abnormal allantois "malformed fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]
Show

Allelic Composition: Pax6Sey/Pax6+
Genetic Background: B10.Cg-Pax6Sey

 MP:0002724 enhanced wound healing "increased ability to self-repair and close wounds" [dlb:Donna Burkart , Mouse Genome Informatics Curator, J:42016]
Show

Allelic Composition: Tsc2tm1Mjg/Tsc2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002942 decreased circulating alanine transaminase level "decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Folh1tm1b(KOMP)Wtsi/Folh1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Folh1tm1b(KOMP)Wtsi/J

 MP:0004259 small placenta "reduced size of the size or shape of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pax6Sey/Pax6+
Genetic Background: B10.Cg-Pax6Sey

 MP:0004560 abnormal chorionic plate morphology "any structural anomaly of the portion of the chorion from which chorionic villi develop that establish a connection with the endometrium, giving rise to the fetal portion of the mature placenta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pax6Sey/Pax6+
Genetic Background: B10.Cg-Pax6Sey

 MP:0005012 decreased eosinophil count "fewer than normal eosinophil numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Folh1tm1b(KOMP)Wtsi/Folh1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Folh1tm1b(KOMP)Wtsi/J

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Tsc2tm1Mjg/Tsc2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Pax6Sey/Pax6+
Genetic Background: B10.Cg-Pax6Sey

 MP:0011521 decreased placental labyrinth size "reduction in the size of the structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [MGI:csmith]
Show

Allelic Composition: Pax6Sey/Pax6+
Genetic Background: B10.Cg-Pax6Sey

 MP:0011525 abnormal placenta intervillous maternal lacunae morphology "any structural anomaly of the spaces of the placenta occupied by maternal blood, into which the fetal labyrinth villi project" [MGI:csmith]
Show

Allelic Composition: Pax6Sey/Pax6+
Genetic Background: B10.Cg-Pax6Sey

 MP:0012099 decreased spongiotrophoblast size "reduction of the size of the middle layer of the placenta between the outermost giant cells and the innermost labyrinth layer; it has a structural role and also produces several layer-specific secreted factors" [MGI:csmith]
Show

Allelic Composition: Pax6Sey/Pax6+
Genetic Background: B10.Cg-Pax6Sey

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
Show

Allelic Composition: Enhotm1.1Butl/Enho+
Genetic Background: B6.Cg-Enhotm1.1Butl

 MP:0013294 prenatal lethality prior to heart atrial septation "death prior to the completion of heart atrial septation (Mus: E14.5-15.5)" [MGI:smb]
Show

Allelic Composition: Enhotm1.1Butl/Enho+
Genetic Background: B6.Cg-Enhotm1.1Butl

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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