ENSMUSG00000058441


Mus musculus

Features
Gene ID: ENSMUSG00000058441
  
Biological name :Panx2
  
Synonyms : Pannexin-2 / Panx2 / Q6IMP4
  
Possible biological names infered from orthology : Q96RD6
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: E3
Gene start: 89059734
Gene end: 89073567
  
Corresponding Affymetrix probe sets: 10426150 (MoGene1.0st)   1440350_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000124354
Ensembl peptide - ENSMUSP00000124928
Ensembl peptide - ENSMUSP00000125514
NCBI entrez gene - 406218     See in Manteia.
MGI - MGI:1890615
RefSeq - NM_001002005
RefSeq - XM_006521139
RefSeq Peptide - NP_001002005
swissprot - F6TVW7
swissprot - Q6IMP4
Ensembl - ENSMUSG00000058441
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 panx2ENSDARG00000063019Danio rerio
 PANX2ENSGALG00000000003Gallus gallus
 PANX2ENSG00000073150Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Panx3 / Q8CEG0 / Pannexin-3 / Q96QZ0*ENSMUSG0000001111815
Panx1 / Q9JIP4 / Pannexin-1 / Q96RD7*ENSMUSG0000003193413


Protein motifs (from Interpro)
Interpro ID Name
 IPR000990  Innexin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002931 response to ischemia IGI
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006812 cation transport IBA
 biological_processGO:0007267 cell-cell signaling IBA
 biological_processGO:0034214 protein hexamerization ISS
 biological_processGO:0055085 transmembrane transport IGI
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0005921 gap junction IEA
 cellular_componentGO:0012505 endomembrane system IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0015267 channel activity IGI
 molecular_functionGO:0022829 wide pore channel activity IBA
 molecular_functionGO:0055077 gap junction hemi-channel activity ISS


Pathways (from Reactome)
Pathway description
Electric Transmission Across Gap Junctions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001539 decreased number of caudal vertebrae "reduced number of the bony segments of the tail" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Izumo1rtm2a(KOMP)Wtsi/Izumo1rtm2a(KOMP)Wtsi
Genetic Background: C57BL/6N-Izumo1rtm2a(KOMP)Wtsi/Wtsi

 MP:0003484 abnormal channel response "anomalies in the electrophysiological recordings from ion channels" [Nmice:Neuromice Consortium Submission]
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Allelic Composition: Panx1tm1.1Fama/Panx1tm1.1Fama,Panx2tm1.1Mony/Panx2tm1.1Mony
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Panx1tm1.1Fama/Panx1+,Panx2tm1.1Mony/Panx2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006058 decreased cerebral infarction size "decreased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply " [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Panx1tm1.1Fama/Panx1tm1.1Fama,Panx2tm1.1Mony/Panx2tm1.1Mony
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006059 decreased susceptibility to ischemic brain injury "decreased lesion size following loss of circulation in a region of the brain; may be induced or spontaneous" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Nsun2tm1c(EUCOMM)Wtsi/Nsun2tm1c(EUCOMM)Wtsi,Tg(KRT14-cre)1Amc/?
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Panx1tm1.1Fama/Panx1tm1.1Fama,Panx2tm1.1Mony/Panx2tm1.1Mony
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031934 Panx1 / Q9JIP4 / Pannexin-1 / Q96RD7*  / complex
 ENSMUSG00000058441 Panx2 / Q6IMP4 / Pannexin-2 / Q96RD6*  / complex






 

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