ENSMUSG00000058975


Mus musculus

Features
Gene ID: ENSMUSG00000058975
  
Biological name :Kcnc1
  
Synonyms : Kcnc1 / P15388 / Potassium voltage-gated channel subfamily C member 1
  
Possible biological names infered from orthology : P48547
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: B3
Gene start: 46396497
Gene end: 46438704
  
Corresponding Affymetrix probe sets: 10553261 (MoGene1.0st)   1423559_at (Mouse Genome 430 2.0 Array)   1443855_at (Mouse Genome 430 2.0 Array)   1456944_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025202
Ensembl peptide - ENSMUSP00000124938
NCBI entrez gene - 16502     See in Manteia.
MGI - MGI:96667
RefSeq - XM_006540648
RefSeq - NM_001112739
RefSeq - NM_008421
RefSeq - XM_006540646
RefSeq - XM_006540647
RefSeq Peptide - NP_001106210
RefSeq Peptide - NP_032447
swissprot - Q3UHB6
swissprot - P15388
Ensembl - ENSMUSG00000058975
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kcnc1aENSDARG00000051852Danio rerio
 kcnc1bENSDARG00000032959Danio rerio
 KCNC1ENSGALG00000006220Gallus gallus
 KCNC1ENSG00000129159Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kcnc3 / potassium voltage-gated channel subfamily C member 3 isoform 2 / Q14003* / potassium voltage-gated channel subfamily C member 3*ENSMUSG0000006278573
Kcnc4 / Q8R1C0 / Potassium voltage-gated channel subfamily C member 4 / Q03721*ENSMUSG0000002789571
Kcnc2 / Q14B80 / Potassium voltage-gated channel subfamily C member 2 / Q96PR1*ENSMUSG0000003568170
Kcna4 / Q61423 / Potassium voltage-gated channel subfamily A member 4 / P22459*ENSMUSG0000004260431
Kcna7 / Q17ST2 / Potassium voltage-gated channel subfamily A member 7 / Q96RP8*ENSMUSG0000003820130
Kcna2 / P63141 / Potassium voltage-gated channel subfamily A member 2 / P16389*ENSMUSG0000004072430
Kcna5 / Q61762 / Potassium voltage-gated channel subfamily A member 5 / P22460*ENSMUSG0000004553430
Kcna3 / P16390 / Potassium voltage-gated channel subfamily A member 3 / P22001*ENSMUSG0000004795930
Kcna1 / P16388 / Potassium voltage-gated channel subfamily A member 1 / Q09470*ENSMUSG0000004797630
Kcna6 / Q61923 / Potassium voltage-gated channel subfamily A member 6 / P17658*ENSMUSG0000003807729
Kcnd3 / Q9Z0V1 / potassium voltage-gated channel, Shal-related family, member 3 / Q9UK17* / potassium voltage-gated channel subfamily D member 3*ENSMUSG0000004089629
Kcnd2 / Q9Z0V2 / Potassium voltage-gated channel subfamily D member 2 / Q9NZV8*ENSMUSG0000006088229
Kcnd1 / Q03719 / Potassium voltage-gated channel subfamily D member 1 / Q9NSA2*ENSMUSG0000000973128
B2RQA1 / Kcna10 / Potassium voltage-gated channel subfamily A member 10 / Q16322*ENSMUSG0000004286128


Protein motifs (from Interpro)
Interpro ID Name
 IPR000210  BTB/POZ domain
 IPR003131  Potassium channel tetramerisation-type BTB domain
 IPR003968  Potassium channel, voltage dependent, Kv
 IPR003974  Potassium channel, voltage dependent, Kv3
 IPR005403  Potassium channel, voltage dependent, Kv3.1
 IPR005821  Ion transport domain
 IPR011333  SKP1/BTB/POZ domain superfamily
 IPR028325  Voltage-gated potassium channel


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0009642 response to light intensity IEA
 biological_processGO:0010996 response to auditory stimulus IEA
 biological_processGO:0014075 response to amine IEA
 biological_processGO:0021549 cerebellum development IEA
 biological_processGO:0021759 globus pallidus development IEA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0034767 positive regulation of ion transmembrane transport IEA
 biological_processGO:0035690 cellular response to drug IEA
 biological_processGO:0035864 response to potassium ion IEA
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0051262 protein tetramerization IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0071774 response to fibroblast growth factor IEA
 biological_processGO:0071805 potassium ion transmembrane transport IBA
 biological_processGO:1901379 regulation of potassium ion transmembrane transport IEA
 biological_processGO:1901381 positive regulation of potassium ion transmembrane transport IEA
 biological_processGO:1903818 positive regulation of voltage-gated potassium channel activity IEA
 biological_processGO:1990089 response to nerve growth factor IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0008076 voltage-gated potassium channel complex ISO
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IBA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0030673 axolemma IDA
 cellular_componentGO:0032589 neuron projection membrane IEA
 cellular_componentGO:0032590 dendrite membrane IDA
 cellular_componentGO:0032809 neuronal cell body membrane IDA
 cellular_componentGO:0043025 neuronal cell body IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005249 voltage-gated potassium channel activity IBA
 molecular_functionGO:0005251 delayed rectifier potassium channel activity IEA
 molecular_functionGO:0005267 potassium channel activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019894 kinesin binding IDA
 molecular_functionGO:0044325 ion channel binding IEA


Pathways (from Reactome)
Pathway description
Voltage gated Potassium channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000243 myoclonus "involuntary shock-like contractions, variable in rhythm and amplitude, followed by relaxation, of a muscle or a group of muscles; generally due to a central nervous system lesion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Col1a1tm1Jae/Col1a1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Col1a1tm1Jae/Col1a1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Col1a1tm1Jae/Col1a1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: Kcnc1tm1Joho/Kcnc1+,Kcnc3tm1Echa/Kcnc3+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
Show

Allelic Composition: Col1a1tm1Jae/Col1a1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Col1a1tm1Jae/Col1a1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Col1a1tm1Jae/Col1a1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Col1a1tm1Jae/Col1a1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: Kcnc1tm1Joho/Kcnc1+,Kcnc3tm1Echa/Kcnc3+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Col1a1tm1Jae/Col1a1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0001415 increased exploration in new environment "greater amount of time spent investigating new location" [J:28825]
Show

Allelic Composition: Col1a1tm1Jae/Col1a1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: Kcnc1tm1Joho/Kcnc1+,Kcnc3tm1Echa/Kcnc3+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
Show

Allelic Composition: Col1a1tm1Jae/Col1a1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0005424 jerky movement "continuous, abrupt, faltering motions of the whole body or a portion of the body" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Col1a1tm1Jae/Col1a1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0005534 decreased body temperature "less than the level of heat natural to a living being" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Col1a1tm1Jae/Col1a1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col1a1tm1Jae/Col1a1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0009751 enhanced behavioral response to alcohol "increased sensitivity to alcohol resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or decreased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col1a1tm1Jae/Col1a1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0011083 complete lethality at weaning "premature death at weaning age of all organisms of a given genotype in a population, often due to the inability to make the transition to solid food" [MGI:csmith]
Show

Allelic Composition: Col1a1tm1Jae/Col1a1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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