ENSMUSG00000060882


Mus musculus

Features
Gene ID: ENSMUSG00000060882
  
Biological name :Kcnd2
  
Synonyms : Kcnd2 / Potassium voltage-gated channel subfamily D member 2 / Q9Z0V2
  
Possible biological names infered from orthology : Q9NZV8
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: A2
Gene start: 21215503
Gene end: 21729805
  
Corresponding Affymetrix probe sets: 10536611 (MoGene1.0st)   1422834_at (Mouse Genome 430 2.0 Array)   1422835_at (Mouse Genome 430 2.0 Array)   1447764_at (Mouse Genome 430 2.0 Array)   1450773_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000080257
NCBI entrez gene - 16508     See in Manteia.
MGI - MGI:102663
RefSeq - NM_019697
RefSeq Peptide - NP_062671
swissprot - Q9Z0V2
Ensembl - ENSMUSG00000060882
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kcnd2ENSDARG00000032799Danio rerio
 KCND2ENSGALG00000009066Gallus gallus
 KCND2ENSG00000184408Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kcnd3 / Q9Z0V1 / potassium voltage-gated channel, Shal-related family, member 3 / Q9UK17* / potassium voltage-gated channel subfamily D member 3*ENSMUSG0000004089677
Kcnd1 / Q03719 / Potassium voltage-gated channel subfamily D member 1 / Q9NSA2*ENSMUSG0000000973168
Kcna2 / P63141 / Potassium voltage-gated channel subfamily A member 2 / P16389*ENSMUSG0000004072428
Kcna5 / Q61762 / Potassium voltage-gated channel subfamily A member 5 / P22460*ENSMUSG0000004553428
Kcna3 / P16390 / Potassium voltage-gated channel subfamily A member 3 / P22001*ENSMUSG0000004795928
Kcna7 / Q17ST2 / Potassium voltage-gated channel subfamily A member 7 / Q96RP8*ENSMUSG0000003820127
Kcna4 / Q61423 / Potassium voltage-gated channel subfamily A member 4 / P22459*ENSMUSG0000004260427
Kcna1 / P16388 / Potassium voltage-gated channel subfamily A member 1 / Q09470*ENSMUSG0000004797627
Kcnc1 / P15388 / Potassium voltage-gated channel subfamily C member 1 / P48547*ENSMUSG0000005897527
Kcnc3 / potassium voltage-gated channel subfamily C member 3 isoform 2 / Q14003* / potassium voltage-gated channel subfamily C member 3*ENSMUSG0000006278527
Kcnc4 / Q8R1C0 / Potassium voltage-gated channel subfamily C member 4 / Q03721*ENSMUSG0000002789526
Kcnc2 / Q14B80 / Potassium voltage-gated channel subfamily C member 2 / Q96PR1*ENSMUSG0000003568126
B2RQA1 / Kcna10 / Potassium voltage-gated channel subfamily A member 10 / Q16322*ENSMUSG0000004286126
Kcna6 / Q61923 / Potassium voltage-gated channel subfamily A member 6 / P17658*ENSMUSG0000003807725


Protein motifs (from Interpro)
Interpro ID Name
 IPR000210  BTB/POZ domain
 IPR003131  Potassium channel tetramerisation-type BTB domain
 IPR003968  Potassium channel, voltage dependent, Kv
 IPR003975  Potassium channel, voltage dependent, Kv4
 IPR004055  Potassium channel, voltage dependent, Kv4.2
 IPR005821  Ion transport domain
 IPR011333  SKP1/BTB/POZ domain superfamily
 IPR021645  Shal-type voltage-gated potassium channels, N-terminal
 IPR024587  Potassium channel, voltage dependent, Kv4, C-terminal
 IPR028325  Voltage-gated potassium channel


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001508 action potential IMP
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0019228 neuronal action potential IMP
 biological_processGO:0019233 sensory perception of pain IMP
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0045475 locomotor rhythm IMP
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0071456 cellular response to hypoxia ISS
 biological_processGO:0071805 potassium ion transmembrane transport ISO
 biological_processGO:0086001 cardiac muscle cell action potential ISS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0005901 caveola ISS
 cellular_componentGO:0008076 voltage-gated potassium channel complex ISO
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030315 T-tubule ISS
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0031226 intrinsic component of plasma membrane IEA
 cellular_componentGO:0032809 neuronal cell body membrane ISS
 cellular_componentGO:0042383 sarcolemma ISS
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043025 neuronal cell body IDA
 cellular_componentGO:0043197 dendritic spine IDA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0044853 plasma membrane raft ISS
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IDA
 cellular_componentGO:0099055 integral component of postsynaptic membrane IC
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005249 voltage-gated potassium channel activity ISS
 molecular_functionGO:0005250 A-type (transient outward) potassium channel activity IEA
 molecular_functionGO:0005267 potassium channel activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Voltage gated Potassium channels
Phase 1 - inactivation of fast Na+ channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002736 abnormal nociception after inflammation "changes in pain thresholds after inflammation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Insrtm1Dac/Insr+,Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0002738 hyperresponsive to tactile stimuli "exaggerated reflex action normally induced by touch or pain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Insrtm1Dac/Insr+,Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Insrtm1Dac/Insr+,Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0003484 abnormal channel response "anomalies in the electrophysiological recordings from ion channels" [Nmice:Neuromice Consortium Submission]
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Allelic Composition: Insrtm1Dac/Insr+,Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

Allelic Composition: Kcnd2tm1Jmn/Kcnd2tm1Jmn
Genetic Background: FVB.129-Kcnd2tm1Jmn

 MP:0003998 decreased thermal nociceptive threshold "a lower than average point at which thermal pain sensation is first detectable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Insrtm1Dac/Insr+,Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000009731 Kcnd1 / Q03719 / Potassium voltage-gated channel subfamily D member 1 / Q9NSA2*  / complex
 ENSMUSG00000025221 Kcnip2 / Q9JJ69 / Kv channel-interacting protein 2 / Q9NS61* / potassium voltage-gated channel interacting protein 2*  / complex
 ENSMUSG00000079056 Kcnip3 / Q9QXT8 / Kv channel interacting protein 3, calsenilin / Q9Y2W7* / potassium voltage-gated channel interacting protein 3*  / complex
 ENSMUSG00000053519 Kcnip1 / Q9JJ57 / Kv channel-interacting protein 1 / Q9NZI2* / potassium voltage-gated channel interacting protein 1*  / complex
 ENSMUSG00000029088 Kcnip4 / Q6PHZ8 / Kv channel interacting protein 4 / Q6PIL6* / potassium voltage-gated channel interacting protein 4*  / complex
 ENSMUSG00000040896 Kcnd3 / Q9Z0V1 / potassium voltage-gated channel, Shal-related family, member 3 / Q9UK17* / potassium voltage-gated channel subfamily D member 3*  / complex
 ENSMUSG00000060882 Kcnd2 / Q9Z0V2 / Potassium voltage-gated channel subfamily D member 2 / Q9NZV8*  / complex






 

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