ENSMUSG00000079056


Mus musculus

Features
Gene ID: ENSMUSG00000079056
  
Biological name :Kcnip3
  
Synonyms : Kcnip3 / Kv channel interacting protein 3, calsenilin / Q9QXT8
  
Possible biological names infered from orthology : potassium voltage-gated channel interacting protein 3 / Q9Y2W7
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: F1
Gene start: 127456498
Gene end: 127522094
  
Corresponding Affymetrix probe sets: 10487392 (MoGene1.0st)   1418544_at (Mouse Genome 430 2.0 Array)   1449129_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028850
Ensembl peptide - ENSMUSP00000085896
Ensembl peptide - ENSMUSP00000099504
NCBI entrez gene - 56461     See in Manteia.
MGI - MGI:1929258
RefSeq - XM_011239710
RefSeq - NM_001111331
RefSeq - NM_001291005
RefSeq - NM_019789
RefSeq Peptide - NP_001104801
RefSeq Peptide - NP_001277934
RefSeq Peptide - NP_062763
swissprot - Q3YAA9
swissprot - Q3YAB0
swissprot - Q9QXT8
swissprot - A2AHT3
Ensembl - ENSMUSG00000079056
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kcnip3bENSDARG00000017880Danio rerio
 KCNIP3ENSG00000115041Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kcnip4 / Q6PHZ8 / Kv channel interacting protein 4 / Q6PIL6* / potassium voltage-gated channel interacting protein 4*ENSMUSG0000002908856
Kcnip2 / Q9JJ69 / Kv channel-interacting protein 2 / Q9NS61* / potassium voltage-gated channel interacting protein 2*ENSMUSG0000002522155
Kcnip1 / Q9JJ57 / Kv channel-interacting protein 1 / Q9NZI2* / potassium voltage-gated channel interacting protein 1*ENSMUSG0000005351949
Ncs1 / Q8BNY6 / Neuronal calcium sensor 1 / P62166*ENSMUSG0000006266129
Vsnl1 / P62761 / visinin-like 1 / P62760*ENSMUSG0000005445926
Hpca / P84075 / Neuron-specific calcium-binding protein hippocalcin / P84074* / hippocalcin*ENSMUSG0000002878525
Hpcal4 / Q8BGZ1 / hippocalcin-like 4 / Q9UM19*ENSMUSG0000004609325
Ncald / Q91X97 / Neurocalcin-delta / P61601*ENSMUSG0000005135925
Hpcal1 / P62748 / Hippocalcin-like protein 1 / P37235* / hippocalcin like 1*ENSMUSG0000007137925
Rcvrn / P34057 / recoverin / P35243*ENSMUSG0000002090724
Guca1b / Q8VBV8 / Guanylyl cyclase-activating protein 2 / Q9UMX6* / guanylate cyclase activator 1B*ENSMUSG0000002397921
Guca1a / P43081 / Guanylyl cyclase-activating protein 1 / P43080* / guanylate cyclase activator 1A*ENSMUSG0000002398218


Protein motifs (from Interpro)
Interpro ID Name
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport TAS
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0019233 sensory perception of pain IMP
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0043523 regulation of neuron apoptotic process IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated TAS
 biological_processGO:0048265 response to pain IMP
 biological_processGO:0048266 behavioral response to pain IMP
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0071805 potassium ion transmembrane transport IEA
 biological_processGO:0072659 protein localization to plasma membrane IDA
 biological_processGO:1901379 regulation of potassium ion transmembrane transport IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0008076 voltage-gated potassium channel complex IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0032993 protein-DNA complex IMP
 molecular_functionGO:0000287 magnesium ion binding IMP
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001046 core promoter sequence-specific DNA binding IMP
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IMP
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005267 potassium channel activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IPI
 molecular_functionGO:0015459 potassium channel regulator activity IMP
 molecular_functionGO:0042803 protein homodimerization activity IMP
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048306 calcium-dependent protein binding IPI


Pathways (from Reactome)
Pathway description
Phase 1 - inactivation of fast Na+ channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
Show

Allelic Composition: Ap3b1pe-8J/Ap3b1pe-8J
Genetic Background: DBA/2J

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Fcgr1tm1Hoga/Fcgr1tm1Hoga
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Fcgr1tm1Hoga/Fcgr1tm1Hoga
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
Show

Allelic Composition: Atmtm1Fwa/Atmtm1Fwa,H2afxtm1Fwa/H2afxtm1Fwa
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Atmtm1Fwa/Atmtm1Fwa,H2afxtm1Fwa/H2afxtm1Fwa
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0002736 abnormal nociception after inflammation "changes in pain thresholds after inflammation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Atmtm1Fwa/Atmtm1Fwa,H2afxtm1Fwa/H2afxtm1Fwa
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0003008 enhanced long term potentiation "greater than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, J:81922]
Show

Allelic Composition: Fcgr1tm1Hoga/Fcgr1tm1Hoga
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003043 hypoalgesia "decreased sensation to painful stimuli that may follow damage to soft tissue containing nociceptors or injury to a peripheral nerve; it can be primary (at the site of the injury) or secondary (in the surrounding undamaged area)" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Atmtm1Fwa/Atmtm1Fwa,H2afxtm1Fwa/H2afxtm1Fwa
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0003484 abnormal channel response "anomalies in the electrophysiological recordings from ion channels" [Nmice:Neuromice Consortium Submission]
Show

Allelic Composition: Fcgr1tm1Hoga/Fcgr1tm1Hoga
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005316 abnormal response to tactile stimuli "anomalous reflex action normally induced by touch or pain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fcgr1tm1Hoga/Fcgr1tm1Hoga
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005498 hyporesponsive to tactile stimuli "reduced reflex action normally induced by touch or pain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Atmtm1Fwa/Atmtm1Fwa,H2afxtm1Fwa/H2afxtm1Fwa
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0008469 abnormal protein level "anomaly in the amount of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fcgr1tm1Hoga/Fcgr1tm1Hoga
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008531 increased chemical nociceptive threshold "a greater than average concentration at which chemically induced pain sensation is first detectable" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atmtm1Fwa/Atmtm1Fwa,H2afxtm1Fwa/H2afxtm1Fwa
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0009453 enhanced contextual conditioning "increase in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ap3b1pe-8J/Ap3b1pe-8J
Genetic Background: DBA/2J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025221 Kcnip2 / Q9JJ69 / Kv channel-interacting protein 2 / Q9NS61* / potassium voltage-gated channel interacting protein 2*  / complex
 ENSMUSG00000009731 Kcnd1 / Q03719 / Potassium voltage-gated channel subfamily D member 1 / Q9NSA2*  / complex
 ENSMUSG00000079056 Kcnip3 / Q9QXT8 / Kv channel interacting protein 3, calsenilin / Q9Y2W7* / potassium voltage-gated channel interacting protein 3*  / complex
 ENSMUSG00000029088 Kcnip4 / Q6PHZ8 / Kv channel interacting protein 4 / Q6PIL6* / potassium voltage-gated channel interacting protein 4*  / complex
 ENSMUSG00000040896 Kcnd3 / Q9Z0V1 / potassium voltage-gated channel, Shal-related family, member 3 / Q9UK17* / potassium voltage-gated channel subfamily D member 3*  / complex
 ENSMUSG00000060882 Kcnd2 / Q9Z0V2 / Potassium voltage-gated channel subfamily D member 2 / Q9NZV8*  / complex
 ENSMUSG00000053519 Kcnip1 / Q9JJ57 / Kv channel-interacting protein 1 / Q9NZI2* / potassium voltage-gated channel interacting protein 1*  / complex






 

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