ENSMUSG00000025221


Mus musculus

Features
Gene ID: ENSMUSG00000025221
  
Biological name :Kcnip2
  
Synonyms : Kcnip2 / Kv channel-interacting protein 2 / Q9JJ69
  
Possible biological names infered from orthology : potassium voltage-gated channel interacting protein 2 / Q9NS61
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: C3
Gene start: 45791839
Gene end: 45816061
  
Corresponding Affymetrix probe sets: 10468113 (MoGene1.0st)   1421783_a_at (Mouse Genome 430 2.0 Array)   1425870_a_at (Mouse Genome 430 2.0 Array)   1436275_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000124821
Ensembl peptide - ENSMUSP00000124763
Ensembl peptide - ENSMUSP00000125142
Ensembl peptide - ENSMUSP00000125499
Ensembl peptide - ENSMUSP00000026247
Ensembl peptide - ENSMUSP00000078400
Ensembl peptide - ENSMUSP00000084215
Ensembl peptide - ENSMUSP00000124346
Ensembl peptide - ENSMUSP00000124482
NCBI entrez gene - 80906     See in Manteia.
MGI - MGI:2135916
RefSeq - XM_017318315
RefSeq - NM_001276358
RefSeq - NM_030716
RefSeq - NM_145703
RefSeq - NM_145704
RefSeq - XM_006527469
RefSeq - XM_006527470
RefSeq Peptide - NP_001263287
RefSeq Peptide - NP_109641
RefSeq Peptide - NP_663749
RefSeq Peptide - NP_663750
swissprot - E9QNK8
swissprot - F6TBA6
swissprot - F7BWB2
swissprot - E0CXC0
swissprot - Q3YAB2
swissprot - Q9JJ69
swissprot - Q3YAB3
swissprot - E0CX94
swissprot - Q3YAA4
swissprot - Q3YAB1
Ensembl - ENSMUSG00000025221
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kcnip2ENSDARG00000075846Danio rerio
 KCNIP2ENSGALG00000007666Gallus gallus
 KCNIP2ENSG00000120049Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kcnip4 / Q6PHZ8 / Kv channel interacting protein 4 / Q6PIL6* / potassium voltage-gated channel interacting protein 4*ENSMUSG0000002908861
Kcnip3 / Q9QXT8 / Kv channel interacting protein 3, calsenilin / Q9Y2W7* / potassium voltage-gated channel interacting protein 3*ENSMUSG0000007905657
Kcnip1 / Q9JJ57 / Kv channel-interacting protein 1 / Q9NZI2* / potassium voltage-gated channel interacting protein 1*ENSMUSG0000005351953
Ncs1 / Q8BNY6 / Neuronal calcium sensor 1 / P62166*ENSMUSG0000006266131
Hpca / P84075 / Neuron-specific calcium-binding protein hippocalcin / P84074* / hippocalcin*ENSMUSG0000002878529
Hpcal4 / Q8BGZ1 / hippocalcin-like 4 / Q9UM19*ENSMUSG0000004609329
Ncald / Q91X97 / Neurocalcin-delta / P61601*ENSMUSG0000005135929
Vsnl1 / P62761 / visinin-like 1 / P62760*ENSMUSG0000005445929
Hpcal1 / P62748 / Hippocalcin-like protein 1 / P37235* / hippocalcin like 1*ENSMUSG0000007137928
Rcvrn / P34057 / recoverin / P35243*ENSMUSG0000002090725
Guca1b / Q8VBV8 / Guanylyl cyclase-activating protein 2 / Q9UMX6* / guanylate cyclase activator 1B*ENSMUSG0000002397922
Guca1a / P43081 / Guanylyl cyclase-activating protein 1 / P43080* / guanylate cyclase activator 1A*ENSMUSG0000002398220


Protein motifs (from Interpro)
Interpro ID Name
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0045163 clustering of voltage-gated potassium channels ISO
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0071435 potassium ion export ISO
 biological_processGO:0071805 potassium ion transmembrane transport ISO
 biological_processGO:0086009 membrane repolarization ISO
 biological_processGO:0097623 potassium ion export across plasma membrane ISO
 biological_processGO:1901379 regulation of potassium ion transmembrane transport ISS
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0008076 voltage-gated potassium channel complex ISO
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005250 A-type (transient outward) potassium channel activity ISO
 molecular_functionGO:0005267 potassium channel activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0015459 potassium channel regulator activity ISO
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0044325 ion channel binding ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047485 protein N-terminus binding ISO


Pathways (from Reactome)
Pathway description
Phase 1 - inactivation of fast Na+ channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001636 irregular heartbeat "uneven timing of heart contraction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33038]
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Allelic Composition: Skiltm2Spw/Skiltm2Spw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0003137 abnormal impulse conducting system conduction "anomaly in the impulse-conducting system composed of modified cardiac muscle and having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart" [hdene:Howard Dene , Mouse Genome Informatics Curator, J:92050, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Skiltm2Spw/Skiltm2Spw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0003897 abnormal ST interval "anomaly in the time between the end of S-wave and the beginning of T-wave" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Skiltm2Spw/Skiltm2Spw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hdac2tm1Lex/Hdac2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000009731 Kcnd1 / Q03719 / Potassium voltage-gated channel subfamily D member 1 / Q9NSA2*  / complex
 ENSMUSG00000025221 Kcnip2 / Q9JJ69 / Kv channel-interacting protein 2 / Q9NS61* / potassium voltage-gated channel interacting protein 2*  / complex
 ENSMUSG00000079056 Kcnip3 / Q9QXT8 / Kv channel interacting protein 3, calsenilin / Q9Y2W7* / potassium voltage-gated channel interacting protein 3*  / complex
 ENSMUSG00000029088 Kcnip4 / Q6PHZ8 / Kv channel interacting protein 4 / Q6PIL6* / potassium voltage-gated channel interacting protein 4*  / complex
 ENSMUSG00000040896 Kcnd3 / Q9Z0V1 / potassium voltage-gated channel, Shal-related family, member 3 / Q9UK17* / potassium voltage-gated channel subfamily D member 3*  / complex
 ENSMUSG00000060882 Kcnd2 / Q9Z0V2 / Potassium voltage-gated channel subfamily D member 2 / Q9NZV8*  / complex
 ENSMUSG00000053519 Kcnip1 / Q9JJ57 / Kv channel-interacting protein 1 / Q9NZI2* / potassium voltage-gated channel interacting protein 1*  / complex






 

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