ENSMUSG00000060279


Mus musculus

Features
Gene ID: ENSMUSG00000060279
  
Biological name :Ap2a1
  
Synonyms : Ap2a1 / AP-2 complex subunit alpha-1 / P17426
  
Possible biological names infered from orthology : adaptor related protein complex 2 alpha 1 subunit / O95782
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: B3
Gene start: 44900373
Gene end: 44929496
  
Corresponding Affymetrix probe sets: 10562965 (MoGene1.0st)   1460724_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000127842
Ensembl peptide - ENSMUSP00000146814
Ensembl peptide - ENSMUSP00000146398
Ensembl peptide - ENSMUSP00000146338
Ensembl peptide - ENSMUSP00000082519
Ensembl peptide - ENSMUSP00000103489
Ensembl peptide - ENSMUSP00000127497
NCBI entrez gene - 11771     See in Manteia.
MGI - MGI:101921
RefSeq - XM_006540570
RefSeq - NM_001077264
RefSeq - NM_007458
RefSeq - XM_006540569
RefSeq Peptide - NP_001070732
RefSeq Peptide - NP_031484
swissprot - A0A140LIG7
swissprot - A0A140LHA6
swissprot - A0A140LHG0
swissprot - P17426
Ensembl - ENSMUSG00000060279
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 AP2A1ENSG00000196961Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ap2a2 / P17427 / Mus musculus adaptor-related protein complex 2, alpha 2 subunit (Ap2a2), transcript variant 1, mRNA. / O94973* / adaptor related protein complex 2 alpha 2 subunit*ENSMUSG0000000295779


Protein motifs (from Interpro)
Interpro ID Name
 IPR002553  Clathrin/coatomer adaptor, adaptin-like, N-terminal
 IPR003164  Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain
 IPR008152  Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain
 IPR009028  Coatomer/calthrin adaptor appendage, C-terminal subdomain
 IPR011989  Armadillo-like helical
 IPR013041  Clathrin adaptor, appendage, Ig-like subdomain superfamily
 IPR016024  Armadillo-type fold
 IPR017104  Adaptor protein complex AP-2, alpha subunit


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport TAS
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0010976 positive regulation of neuron projection development IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport TAS
 biological_processGO:0048260 positive regulation of receptor-mediated endocytosis IEA
 biological_processGO:0072583 clathrin-dependent endocytosis IEA
 biological_processGO:1900126 negative regulation of hyaluronan biosynthetic process ISO
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005905 clathrin-coated pit IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0030117 membrane coat IDA
 cellular_componentGO:0030131 clathrin adaptor complex IEA
 cellular_componentGO:0030136 clathrin-coated vesicle IEA
 cellular_componentGO:0030141 secretory granule TAS
 cellular_componentGO:0032433 filopodium tip IDA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0035615 clathrin adaptor activity IEA
 molecular_functionGO:0050750 low-density lipoprotein particle receptor binding ISO


Pathways (from Reactome)
Pathway description
Retrograde neurotrophin signalling
MHC class II antigen presentation
Trafficking of GluR2-containing AMPA receptors
Recycling pathway of L1
WNT5A-dependent internalization of FZD4
WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
VLDLR internalisation and degradation
LDL clearance


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022841 Ap2m1 / P84091 / AP-2 complex subunit mu / Q96CW1* / adaptor related protein complex 2 mu 1 subunit*  / complex
 ENSMUSG00000020888 Dvl2 / Q60838 / Segment polarity DVL-2 / O14641* / dishevelled segment polarity protein 2*  / complex / reaction
 ENSMUSG00000035152 Ap2b1 / Q9DBG3 / AP-2 complex subunit beta / P63010* / adaptor related protein complex 2 beta 1 subunit*  / complex
 ENSMUSG00000068206 Pick1 / protein interacting with C kinase 1 / Q9NRD5* / protein interacting with PRKCA 1*  / reaction
 ENSMUSG00000022420 Dnal4 / Q9DCM4 / Dynein light chain 4, axonemal / O96015* / dynein axonemal light chain 4*  / reaction
 ENSMUSG00000024924 Vldlr / P98156 / very low density lipoprotein receptor / P98155*  / complex / reaction
 ENSMUSG00000032193 Ldlr / P35951 / Low-density lipoprotein receptor / P01130*  / complex / reaction
 ENSMUSG00000028488 Q62420 / Sh3gl2 / SH3-domain GRB2-like 2 / Q99962* / SH3 domain containing GRB2 like 2, endophilin A1*  / complex / reaction
 ENSMUSG00000036594 H2-Aa / P14434 / H-2 class II histocompatibility antigen, A-B alpha chain / P01909* / P01906* / HLA-DQA2* / HLA-DQA1* / major histocompatibility complex, class II, DQ alpha 2* / major hist...  / complex / reaction
 ENSMUSG00000028072 Ntrk1 / Q3UFB7 / High affinity nerve growth factor receptor / P04629* / neurotrophic receptor tyrosine kinase 1*  / complex
 ENSMUSG00000027859 Ngf / P01139 / Beta-nerve growth factor / P01138* / nerve growth factor*  / complex
 ENSMUSG00000073421 H2-Ab1 / P14483 / histocompatibility 2, class II antigen A, beta 1 / P05538* / HLA-DQB1* / HLA-DQB2* / major histocompatibility complex, class II, DQ beta 1* / major histocompatibility comp...  / complex / reaction
 ENSMUSG00000034813 Grip1 / Q925T6 / Glutamate receptor-interacting protein 1 / Q9Y3R0*  / reaction
 ENSMUSG00000034311 Kif4 / P33174 / Chromosome-associated kinesin KIF4 / KIF4A* / KIF4B* / Q2VIQ3* / O95239* / kinesin family member 4B* / kinesin family member 4A*  / complex
 ENSMUSG00000024610 Cd74 / P04441 / CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) / P04233* / CD74 molecule*  / complex / reaction
 ENSMUSG00000067341 H2-Eb2 / Q9GIY3* / P01911* / P04229* / Q29974* / Q30154* / HLA-DRB5* / HLA-DRB1* / major histocompatibility complex, class II, DR beta 1* / major histocompatibility complex, class II, DR beta 5*  / complex / reaction
 ENSMUSG00000021994 Wnt5a / P22725 / wingless-type MMTV integration site family, member 5A / P41221* / Wnt family member 5A*  / complex / reaction
 ENSMUSG00000063358 Mapk1 / P63085 / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA. / P28482* / mitogen-activated protein kinase 1*  / complex / reaction
 ENSMUSG00000044254 Pcsk9 / Q80W65 / Proprotein convertase subtilisin/kexin type 9 / Q8NBP7*  / complex / reaction
 ENSMUSG00000049791 Fzd4 / Q61088 / Frizzled-4 / Q9ULV1* / frizzled class receptor 4*  / complex / reaction
 ENSMUSG00000008036 Ap2s1 / P62743 / AP-2 complex subunit sigma / P53680* / adaptor related protein complex 2 sigma 1 subunit*  / complex
 ENSMUSG00000002957 Ap2a2 / P17427 / Mus musculus adaptor-related protein complex 2, alpha 2 subunit (Ap2a2), transcript variant 1, mRNA. / O94973* / adaptor related protein complex 2 alpha 2 subunit*  / complex
 ENSMUSG00000022048 Dpysl2 / O08553 / Dihydropyrimidinase-related protein 2 / Q16555* / dihydropyrimidinase like 2*  / complex
 ENSMUSG00000021224 Numb / Q9QZS3 / NUMB, endocytic adaptor protein / P49757*  / complex
 ENSMUSG00000025892 Gria4 / Q9Z2W8 / glutamate receptor, ionotropic, AMPA4 (alpha 4) / P48058* / glutamate ionotropic receptor AMPA type subunit 4*  / reaction
 ENSMUSG00000020524 Gria1 / P23818 / Glutamate receptor 1 / P42261* / glutamate ionotropic receptor AMPA type subunit 1*  / reaction
 ENSMUSG00000047547 Cltb / Q6IRU5 / Clathrin light chain B / P09497*  / complex
 ENSMUSG00000060216 Arrb2 / Q91YI4 / Beta-arrestin-2 / P32121* / arrestin beta 2*  / complex / reaction
 ENSMUSG00000001986 Gria3 / Q9Z2W9 / Mus musculus glutamate receptor, ionotropic, AMPA3 (alpha 3) (Gria3), transcript variant 5, mRNA. / P42263* / glutamate ionotropic receptor AMPA type subunit 3*  / reaction
 ENSMUSG00000060279 Ap2a1 / P17426 / AP-2 complex subunit alpha-1 / O95782* / adaptor related protein complex 2 alpha 1 subunit*  / complex
 ENSMUSG00000060586 H2-Eb1 / Q9GIY3* / P01911* / P04229* / Q29974* / Q30154* / HLA-DRB5* / HLA-DRB1* / major histocompatibility complex, class II, DR beta 1* / major histocompatibility complex, class II, DR beta 5*  / complex / reaction






 

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