ENSMUSG00000060969


Mus musculus

Features
Gene ID: ENSMUSG00000060969
  
Biological name :Irx1
  
Synonyms : Iroquois-class homeodomain protein IRX-1 / Irx1 / P81068
  
Possible biological names infered from orthology : iroquois homeobox 1 / P78414
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: C1
Gene start: 71957921
Gene end: 71963723
  
Corresponding Affymetrix probe sets: 10410501 (MoGene1.0st)   1451983_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000076562
Ensembl peptide - ENSMUSP00000152247
Ensembl peptide - ENSMUSP00000152128
NCBI entrez gene - 16371     See in Manteia.
MGI - MGI:1197515
RefSeq - NM_010573
RefSeq Peptide - NP_034703
swissprot - A0A1Y7VJ15
swissprot - A0A1Y7VIS3
swissprot - P81068
Ensembl - ENSMUSG00000060969
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 irx1aENSDARG00000101831Danio rerio
 IRX1ENSGALG00000030991Gallus gallus
 IRX1ENSG00000170549Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Irx3 / P81067 / Iroquois-class homeodomain protein IRX-3 / P78415* / iroquois homeobox 3*ENSMUSG0000003173438
Irx4 / Q9QY61 / Iroquois-class homeodomain protein IRX-4 / P78413* / iroquois homeobox 4*ENSMUSG0000002160432
Irx5 / Q9JKQ4 / Iroquois-class homeodomain protein IRX-5 / P78411* / iroquois homeobox 5*ENSMUSG0000003173732
Irx6 / Q9ER75 / Iroquois-class homeodomain protein IRX-6 / P78412* / iroquois homeobox 6*ENSMUSG0000003173831
Irx2 / P81066 / Iroquois-class homeodomain protein IRX-2 / Q9BZI1* / iroquois homeobox 2*ENSMUSG0000000150430
Mkx / mohawk homeobox / Q8IYA7*ENSMUSG0000006101315


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR003893  Iroquois-class homeodomain protein
 IPR008422  Homeobox KN domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001656 metanephros development IEP
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0072086 specification of loop of Henle identity IEP
 biological_processGO:0072272 proximal/distal pattern formation involved in metanephric nephron development IEP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Fzd4tm1.1(KOMP)Vlcg/Fzd4tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Fzd4tm1.1(KOMP)Vlcg/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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