ENSMUSG00000060985


Mus musculus

Features
Gene ID: ENSMUSG00000060985
  
Biological name :Tdrd5
  
Synonyms : Q5VCS6 / Tdrd5 / Tudor domain-containing protein 5
  
Possible biological names infered from orthology : Q8NAT2 / tudor domain containing 5
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: G3
Gene start: 156255296
Gene end: 156303664
  
Corresponding Affymetrix probe sets: 10359118 (MoGene1.0st)   1456391_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000137156
Ensembl peptide - ENSMUSP00000137182
Ensembl peptide - ENSMUSP00000137298
NCBI entrez gene - 214575     See in Manteia.
MGI - MGI:2684949
RefSeq - XM_006496734
RefSeq - XM_006496729
RefSeq - XM_006496730
RefSeq - XM_006496731
RefSeq - XM_006496732
RefSeq - XM_006496733
RefSeq - NM_001134741
RefSeq - NM_001277730
RefSeq - XM_006496726
RefSeq - XM_006496727
RefSeq - XM_006496728
RefSeq Peptide - NP_001128213
RefSeq Peptide - NP_001264659
swissprot - J3QPB7
swissprot - Q5VCS6
swissprot - J3QP93
Ensembl - ENSMUSG00000060985
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tdrd5ENSDARG00000071450Danio rerio
 TDRD5ENSGALG00000033634Gallus gallus
 TDRD5ENSG00000162782Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tdrd6 / tudor domain-containing protein 6 isoform 3 / O60522* / tudor domain containing 6*ENSMUSG0000004014013
Rnf17 / Q99MV7 / RING finger protein 17 / Q9BXT8*ENSMUSG0000000036512
Tdrkh / Q80VL1 / Mus musculus tudor and KH domain containing protein (Tdrkh), transcript variant 4, mRNA. / Q9Y2W6* / tudor and KH domain containing*ENSMUSG0000004191212
Tdrd1 / Q99MV1 / Tudor domain-containing protein 1 / Q9BXT4* / tudor domain containing 1*ENSMUSG0000002508111


Protein motifs (from Interpro)
Interpro ID Name
 IPR002999  Tudor domain
 IPR025605  OST-HTH/LOTUS domain
 IPR035437  SNase-like, OB-fold superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007281 germ cell development IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0007286 spermatid development IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030719 P granule organization IMP
 biological_processGO:0043046 DNA methylation involved in gamete generation IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0033391 chromatoid body IDA
 cellular_componentGO:0071546 pi-body IDA
 molecular_functionGO:0003674 molecular_function ND


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Hic1tm2.1Kori/Hic1tm2.1Kori
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0001153 small seminiferous tubules "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]
Show

Allelic Composition: Hic1tm2.1Kori/Hic1tm2.1Kori
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0001155 arrest of spermatogenesis "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]
Show

Allelic Composition: Hic1tm2.1Kori/Hic1tm2.1Kori
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Tdrd5tm1c(EUCOMM)Hmgu/Tdrd5tm1c(EUCOMM)Hmgu,Tg(Stra8-icre)1Reb/0
Genetic Background: involves: C57BL/6N * FVB/NJ

Allelic Composition: Tdrd5tm1a(EUCOMM)Hmgu/Tdrd5tm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6-Tdrd5tm1a(EUCOMM)Hmgu

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Hic1tm2.1Kori/Hic1tm2.1Kori
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Tdrd5tm1c(EUCOMM)Hmgu/Tdrd5tm1c(EUCOMM)Hmgu,Tg(Stra8-icre)1Reb/0
Genetic Background: involves: C57BL/6N * FVB/NJ

Allelic Composition: Tdrd5tm1a(EUCOMM)Hmgu/Tdrd5tm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6-Tdrd5tm1a(EUCOMM)Hmgu

 MP:0002686 globozoospermia "malformation of the acrosome resulting in a round sperm head" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Hic1tm2.1Kori/Hic1tm2.1Kori
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0003205 testicular atrophy "wasting of the male reproductive glands resulting in reduced size" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Tdrd5tm1c(EUCOMM)Hmgu/Tdrd5tm1c(EUCOMM)Hmgu,Tg(Stra8-icre)1Reb/0
Genetic Background: involves: C57BL/6N * FVB/NJ

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hic1tm2.1Kori/Hic1tm2.1Kori
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Tdrd5tm1c(EUCOMM)Hmgu/Tdrd5tm1c(EUCOMM)Hmgu,Tg(Stra8-icre)1Reb/0
Genetic Background: involves: C57BL/6N * FVB/NJ

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hic1tm2.1Kori/Hic1tm2.1Kori
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0006379 abnormal spermatocyte morphology "anomaly in the number or structure of male germ cells that through meiosis give rise to spermatids " [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hic1tm2.1Kori/Hic1tm2.1Kori
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Hic1tm2.1Kori/Hic1tm2.1Kori
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hic1tm2.1Kori/Hic1tm2.1Kori
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0008898 abnormal acrosome morphology "any structural anomaly of the cap-like structure at the anterior end of the sperm head that produces enzymes needed for egg penetration" [MESH:A05.360.490.890.820.100]
Show

Allelic Composition: Hic1tm2.1Kori/Hic1tm2.1Kori
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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