ENSMUSG00000061601


Mus musculus
bindingPclosynapticpresynapticactivezonedomainproteinsynapseincreasedcpdzzincfingersuperfamilyvesiclesignalingpostsynapticionpiccolo-typefyvephd-typepiccolocytoskeletonorganizationassemblytargetingregulationexocytosiscamp-mediatedinsulin

Features
Gene ID: ENSMUSG00000061601
  
Biological name :Pclo
  
Synonyms : Pclo / Protein piccolo / Q9QYX7
  
Possible biological names infered from orthology : piccolo presynaptic cytomatrix protein / Q9Y6V0
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: A1
Gene start: 14514918
Gene end: 14863459
  
Corresponding Affymetrix probe sets: 10519770 (MoGene1.0st)   1419392_at (Mouse Genome 430 2.0 Array)   1452423_at (Mouse Genome 430 2.0 Array)   1455373_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030691
Ensembl peptide - ENSMUSP00000138419
Ensembl peptide - ENSMUSP00000138607
NCBI entrez gene - 26875     See in Manteia.
MGI - MGI:1349390
RefSeq - XM_006503586
RefSeq - NM_001110796
RefSeq - NM_011995
RefSeq - XM_006503582
RefSeq - XM_006503583
RefSeq - XM_006503584
RefSeq Peptide - NP_001104266
RefSeq Peptide - NP_036125
swissprot - Q9QYX7
swissprot - S4R2E0
Ensembl - ENSMUSG00000061601
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pcloaENSDARG00000063299Danio rerio
 pclobENSDARG00000098880Danio rerio
 ENSGALG00000037435Gallus gallus
 ENSGALG00000039659Gallus gallus
 ENSGALG00000040151Gallus gallus
 PCLOENSG00000186472Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Bsn / O88737 / Protein bassoon / Q9UPA5* / bassoon presynaptic cytomatrix protein*ENSMUSG0000003258925


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR001478  PDZ domain
 IPR008899  Zinc finger, piccolo-type
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR030629  Protein piccolo
 IPR035892  C2 domain superfamily
 IPR036034  PDZ superfamily


Gene Ontology (GO)
cellular component organizationcellular component biogenesisanatomical structure developmentcell communicationestablishment of localizationregulation of biological qualitycellular localizationcellular response to stimulusmacromolecule localizationcellular component organizationcellular component biogenesisanatomical structure developmentcell communicationestablishment of localizationregulation of biological qualitycellular localizationcellular response to stimulusmacromolecule localizationcellular component organizationcellular component biogenesisanatomical structure developmentcell communicationestablishment of localizationregulation of biological qualitycellular localizationcellular response to stimulusmacromolecule localizationcellular component organizationcellular component biogenesisanatomical structure developmentcell communicationestablishment of localizationregulation of biological qualitycellular localizationcellular response to stimulusmacromolecule localizationcellular component organizationcellular component biogenesisanatomical structure developmentcell communicationestablishment of localizationregulation of biological qualitycellular localizationcellular response to stimulusmacromolecule localizationcellular component organizationcellular component biogenesisanatomical structure developmentcell communicationestablishment of localizationregulation of biological qualitycellular localizationcellular response to stimulusmacromolecule localizationcellular component organizationcellular component biogenesisanatomical structure developmentcell communicationestablishment of localizationregulation of biological qualitycellular localizationcellular response to stimulusmacromolecule localizationcellular component organizationcellular component biogenesisanatomical structure developmentcell communicationestablishment of localizationregulation of biological qualitycellular localizationcellular response to stimulusmacromolecule localizationcellular component organizationcellular component biogenesisanatomical structure developmentcell communicationestablishment of localizationregulation of biological qualitycellular localizationcellular response to stimulusmacromolecule localizationcellular component organizationcellular component biogenesisanatomical structure developmentcell communicationestablishment of localizationregulation of biological qualitycellular localizationcellular response to stimulusmacromolecule localizationcellular componcellular component organizationcellular componcellular component biogenesisanatomical struanatomical structure developmentcell communicatcell communicationestablishment oestablishment of localizationregulation of bregulation of biological qualitycellular localicellular localizationcellular responcellular response to stimulusmacromolecule lmacromolecule localization
ion bindingprotein bindinglipid bindingstructural constituent of synapseion bindingprotein bindinglipid bindingstructural constituent of synapseion bindingprotein bindinglipid bindingstructural constituent of synapseion bindingprotein bindinglipid bindingstructural constituent of synapseion bindingprotein bindinglipid bindingstructural constituent of synapseion bindingprotein bindinglipid bindingstructural constituent of synapseion bindingprotein bindinglipid bindingstructural constituent of synapseion bindingprotein bindinglipid bindingstructural constituent of synapseion bindingprotein bindinglipid bindingstructural constituent of synapseion bindingprotein bindinglipid bindingstructural constituent of synapseion bindingion bindingprotein bindingprotein bindinglipid bindinglipid bindingstructural constituent of synapsestructural constituent of synapse
cellsynapseorganellecell junctioncellsynapseorganellecell junctioncellsynapseorganellecell junctioncellsynapseorganellecell junctioncellsynapseorganellecell junctioncellsynapseorganellecell junctioncellsynapseorganellecell junctioncellsynapseorganellecell junctioncellsynapseorganellecell junctioncellsynapseorganellecell junctioncellcellsynapsesynapseorganelleorganellecell junctioncell junction
TypeGO IDTermEv.Code
 biological_processGO:0007010 cytoskeleton organization IDA
 biological_processGO:0007416 synapse assembly IEA
 biological_processGO:0016080 synaptic vesicle targeting NAS
 biological_processGO:0017157 regulation of exocytosis IDA
 biological_processGO:0019933 cAMP-mediated signaling IDA
 biological_processGO:0030073 insulin secretion IDA
 biological_processGO:0035418 protein localization to synapse IGI
 biological_processGO:0048790 maintenance of presynaptic active zone structure IC
 biological_processGO:0099526 presynapse to nucleus signaling pathway IMP
 cellular_componentGO:0014069 postsynaptic density IDA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0045202 synapse IDA
 cellular_componentGO:0048786 presynaptic active zone IEA
 cellular_componentGO:0098831 presynaptic active zone cytoplasmic component IDA
 molecular_functionGO:0005509 calcium ion binding ISS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005522 profilin binding IDA
 molecular_functionGO:0005544 calcium-dependent phospholipid binding ISS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0098882 structural constituent of presynaptic active zone IC


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
growth/size phenotypemortality/agingnervous system phenotypegrowth/size phenotypemortality/agingnervous system phenotypegrowth/size phenotypemortality/agingnervous system phenotypegrowth/size phenotypemortality/agingnervous system phenotypegrowth/size phenotypemortality/agingnervous system phenotypegrowth/size phenotypemortality/agingnervous system phenotypegrowth/size phenotypemortality/agingnervous system phenotypegrowth/size phenotypemortality/agingnervous system phenotypegrowth/size phenotypemortality/agingnervous system phenotypegrowth/size phenotypemortality/agingnervous system phenotypegrowth/size phenotypegrowth/size phenotypemortality/agingmortality/agingnervous system phenotypenervous system phenotype
IDPhenotypeDefinition Genetic BG
 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Blnkm1Btlr/Blnkm1Btlr
Genetic Background: C57BL/6J-Blnkm1Btlr

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Blnkm1Btlr/Blnkm1Btlr
Genetic Background: C57BL/6J-Blnkm1Btlr

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sox10m2C3HeB/FeJ/Sox10m2C3HeB/FeJ,Sox10Dom/Sox10Dom
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Pclotm3.1Sud/Pclotm3.1Sud
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pclotm2Sud/Pclotm2Sud
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Pclotm3.3Sud/Pclotm3.3Sud
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Apobtm2Sgy/Apobtm2Sgy,Apoetm1Unc/Apoetm1Unc,Lepob/Lepob
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0002916 increased synaptic depression "increase in the duration of the reduction of effectiveness of synaptic connections between neurons and target after repetitive stimulation" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Blnkm1Btlr/Blnkm1Btlr
Genetic Background: C57BL/6J-Blnkm1Btlr

Allelic Composition: Pclotm1.1Mver/Pclotm1.1Mver
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0004792 abnormal synaptic vesicle number "anomaly in the number of the small, membrane bound sacs that contain various neurotransmitter molecules that are concentrated at pre-synaptic membranes and release the neurotransmitters by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Blnkm1Btlr/Blnkm1Btlr
Genetic Background: C57BL/6J-Blnkm1Btlr

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Blnkm1Btlr/Blnkm1Btlr
Genetic Background: C57BL/6J-Blnkm1Btlr

 MP:0008921 increased neurotransmitter release "increased production or release of endogenous signaling molecules normally secreted by neurons that alter the behavior of neurons or effector cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pclotm1.1Mver/Pclotm1.1Mver
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0011269 increased excitatory postsynaptic current amplitude "increase in the size (height or maximum displacement) of the evoked excitatory postsynaptic current wave" [MGI:csmith]
Show

Allelic Composition: Pclotm1.1Mver/Pclotm1.1Mver
Genetic Background: involves: C57BL/6 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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