ENSMUSG00000062345
Mus musculus decreased Serpinb2 serpin activity count body regulation peptidase endopeptidase extracellular inhibitor size family plasminogen activator inhibitor- conserved site domain superfamily wound healing apoptotic process region space cytoplasm serine-type dissolution fibrin clot
Features Gene ID: ENSMUSG00000062345 Biological name :Serpinb2 Synonyms : P12388 / / Possible biological names infered from orthology : P05120 / Species: Mus musculus Chr. number: 1 Strand: 1 Band: E2.1 Gene start: 107511423 Gene end: 107535478 Corresponding Affymetrix probe sets: 10349157 (MoGene1.0st) 1419082_at (Mouse Genome 430 2.0 Array) Cross references: Ensembl peptide - ENSMUSP0000000935618788
See in Manteia .
MGI:97609 NM_011111 XM_011247942 NM_001174170 NP_001167641 NP_035241 F6QN99 P12388 Q542A3 F6ZFV0 ENSMUSG00000062345
See expression report in BioGPS See gene description in Wikigenes See co-cited genes in PubMed Ortholog prediction (from Ensembl )Paralog prediction (from Ensembl ) Q9D154 / Serpinb1a / serine (or cysteine) peptidase inhibitor, clade B, member 1a / P30740* / SERPINB1* / serpin family B member 1* ENSMUSG00000044734 41 Q8VHP7 / Serpinb1b / serine (or cysteine) peptidase inhibitor, clade B, member 1b / P30740* / SERPINB1* / serpin family B member 1* ENSMUSG00000051029 41 Q60854 / Serpinb6a / serine (or cysteine) peptidase inhibitor, clade B, member 6a / P35237* / SERPINB6* / serpin family B member 6* ENSMUSG00000060147 41 O08800 / Serpinb8 / Serpin B8 / P50452* / serpin family B member 8* ENSMUSG00000026315 39 Serpinb6b / serine (or cysteine) peptidase inhibitor, clade B, member 6b / P35237* / SERPINB6* / serpin family B member 6* ENSMUSG00000042842 39 Serpinb9 / serine (or cysteine) peptidase inhibitor, clade B, member 9 / P50453* / serpin family B member 9* ENSMUSG00000045827 39 Q5SV42 / Serpinb1c / serine (or cysteine) peptidase inhibitor, clade B, member 1c / P30740* / SERPINB1* / serpin family B member 1* ENSMUSG00000079049 39 Serpinb9b / serine (or cysteine) peptidase inhibitor, clade B, member 9b / P50453* / SERPINB9* / serpin family B member 9* ENSMUSG00000021403 38 Serpinb3a / P48594* / P29508* / SERPINB3* / SERPINB4* / serpin family B member 3* / serpin family B member 4* ENSMUSG00000044594 38 Serpinb9d / serine (or cysteine) peptidase inhibitor, clade B, member 9d / P50453* / SERPINB9* / serpin family B member 9* ENSMUSG00000054266 38 Serpinb9e / serine (or cysteine) peptidase inhibitor, clade B, member 9e / P50453* / SERPINB9* / serpin family B member 9* ENSMUSG00000062342 38 Serpinb9f / P50453* / SERPINB9* / serpin family B member 9* ENSMUSG00000038327 37 Serpinb6d / serine (or cysteine) peptidase inhibitor, clade B, member 6d / P35237* / SERPINB6* / serpin family B member 6* ENSMUSG00000047889 37 Serpinb6c / serine (or cysteine) peptidase inhibitor, clade B, member 6c / P35237* / SERPINB6* / serpin family B member 6* ENSMUSG00000052180 37 Serpinb9g / serine (or cysteine) peptidase inhibitor, clade B, member 9g / P50453* / SERPINB9* / serpin family B member 9* ENSMUSG00000057726 37 Gm11397 / P50453* / SERPINB9* / serpin family B member 9* ENSMUSG00000071452 37 Serpinb3b / serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3B / P29508* / P48594* / SERPINB3* / SERPINB4* / serpin family B member 3* / serpin family B member 4* ENSMUSG00000073602 37 Serpinb9c / serine (or cysteine) peptidase inhibitor, clade B, member 9c / P50453* / SERPINB9* / serpin family B member 9* ENSMUSG00000021404 36 Serpinb3d / P48594* / P29508* / SERPINB3* / SERPINB4* / serpin family B member 3* / serpin family B member 4* ENSMUSG00000058017 36 Serpinb3c / P48594* / P29508* / SERPINB3* / SERPINB4* / serpin family B member 3* / serpin family B member 4* ENSMUSG00000073601 36
Protein motifs (from Interpro )Gene Ontology (GO ) nitrogen compound metabolic process cellular metabolic process primary metabolic process regulation of molecular function organic substance metabolic process response to stress cell death nitrogen compound metabolic process cellular metabolic process primary metabolic process regulation of molecular function organic substance metabolic process response to stress cell death nitrogen compound metabolic process cellular metabolic process primary metabolic process regulation of molecular function organic substance metabolic process response to stress cell death nitrogen compound metabolic process cellular metabolic process primary metabolic process regulation of molecular function organic substance metabolic process response to stress cell death nitrogen compound metabolic process cellular metabolic process primary metabolic process regulation of molecular function organic substance metabolic process response to stress cell death nitrogen compound metabolic process cellular metabolic process primary metabolic process regulation of molecular function organic substance metabolic process response to stress cell death nitrogen compound metabolic process cellular metabolic process primary metabolic process regulation of molecular function organic substance metabolic process response to stress cell death nitrogen compound metabolic process cellular metabolic process primary metabolic process regulation of molecular function organic substance metabolic process response to stress cell death nitrogen compound metabolic process cellular metabolic process primary metabolic process regulation of molecular function organic substance metabolic process response to stress cell death nitrogen compound metabolic process cellular metabolic process primary metabolic process regulation of molecular function organic substance metabolic process response to stress cell death nitrogen compound menitrogen compound metabolic process cellular metabolic pcellular metabolic process primary metabolic prprimary metabolic process regulation of molecuregulation of molecular function organic substance meorganic substance metabolic process response to stressresponse to stress cell deathcell death enzyme regulator activity enzyme regulator activity enzyme regulator activity enzyme regulator activity enzyme regulator activity enzyme regulator activity enzyme regulator activity enzyme regulator activity enzyme regulator activity enzyme regulator activity enzyme regulator activityenzyme regulator activity extracellular region cell extracellular region cell extracellular region cell extracellular region cell extracellular region cell extracellular region cell extracellular region cell extracellular region cell extracellular region cell extracellular region cell extracellular regionextracellular region cellcell
Pathways (from Reactome )Phenotype (from MGI , Zfin or HPO ) immune system phenotype hematopoietic system phenotype growth/size phenotype mortality/aging muscle phenotype immune system phenotype hematopoietic system phenotype growth/size phenotype mortality/aging muscle phenotype immune system phenotype hematopoietic system phenotype growth/size phenotype mortality/aging muscle phenotype immune system phenotype hematopoietic system phenotype growth/size phenotype mortality/aging muscle phenotype immune system phenotype hematopoietic system phenotype growth/size phenotype mortality/aging muscle phenotype immune system phenotype hematopoietic system phenotype growth/size phenotype mortality/aging muscle phenotype immune system phenotype hematopoietic system phenotype growth/size phenotype mortality/aging muscle phenotype immune system phenotype hematopoietic system phenotype growth/size phenotype mortality/aging muscle phenotype immune system phenotype hematopoietic system phenotype growth/size phenotype mortality/aging muscle phenotype immune system phenotype hematopoietic system phenotype growth/size phenotype mortality/aging muscle phenotype immune system phenotypeimmune system phenotype hematopoietic system phenotyhematopoietic system phenotype growth/size phenotypegrowth/size phenotype mortality/agingmortality/aging muscle phenotypemuscle phenotype MP:0000217 abnormal white blood cell count "anomalies in the number of leukocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cdkn1btm1Mlf /Cdkn1btm1Mlf ,Trp53tm1Brd /Trp53tm1Brd Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6JAllelic Composition: Serpinb2tm2Dgi /Serpinb2tm2Dgi Genetic Background: involves: 129S2/SvPas * C57BL/6J * DBA/2J
MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdkn1btm1Mlf /Cdkn1btm1Mlf ,Trp53tm1Brd /Trp53tm1Brd Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6JAllelic Composition: Serpinb2tm2Dgi /Serpinb2tm2Dgi Genetic Background: involves: 129S2/SvPas * C57BL/6J * DBA/2J
MP:0000223 decreased monocyte count "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdkn1btm1Mlf /Cdkn1btm1Mlf ,Trp53tm1Brd /Trp53tm1Brd Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6JAllelic Composition: Serpinb2tm2Dgi /Serpinb2tm2Dgi Genetic Background: involves: 129S2/SvPas * C57BL/6J * DBA/2J
MP:0001255 decreased body height "decreased shoulder to floor distance compared to controls" [dlb:Donna Burkart, Mouse Genome Informatics Curator]
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Allelic Composition: Irs1smla /Irs1smla ,Serpinb2tm2Dgi /Serpinb2tm2Dgi Genetic Background: involves: 129S2/SvPas * C57BL/6J * DBA/2J
MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Irs1smla /Irs1smla ,Serpinb2tm2Dgi /Serpinb2tm2Dgi Genetic Background: involves: 129S2/SvPas * C57BL/6J * DBA/2J
MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Serpinb2tm2Dgi /Serpinb2tm2Dgi Genetic Background: involves: 129S2/SvPas * C57BL/6J * DBA/2J
MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Irs1smla /Irs1smla ,Serpinb2tm2Dgi /Serpinb2tm2Dgi Genetic Background: involves: 129S2/SvPas * C57BL/6J * DBA/2J
MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Irs1smla /Irs1smla ,Serpinb2tm2Dgi /Serpinb2tm2Dgi Genetic Background: involves: 129S2/SvPas * C57BL/6J * DBA/2J
MP:0002269 muscular atrophy "a wasting of muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Irs1smla /Irs1smla ,Serpinb2tm2Dgi /Serpinb2tm2Dgi Genetic Background: involves: 129S2/SvPas * C57BL/6J * DBA/2J
MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Cdkn1btm1Mlf /Cdkn1btm1Mlf ,Trp53tm1Brd /Trp53tm1Brd Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6JAllelic Composition: Serpinb2tm2Dgi /Serpinb2tm2Dgi Genetic Background: involves: 129S2/SvPas * C57BL/6J * DBA/2J
MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdkn1btm1Mlf /Cdkn1btm1Mlf ,Trp53tm1Brd /Trp53tm1Brd Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6JAllelic Composition: Serpinb2tm2Dgi /Serpinb2tm2Dgi Genetic Background: involves: 129S2/SvPas * C57BL/6J * DBA/2J
MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Irs1smla /Irs1smla ,Serpinb2tm2Dgi /Serpinb2tm2Dgi Genetic Background: involves: 129S2/SvPas * C57BL/6J * DBA/2J
Interacting proteins (from Reactome ) ENSMUSG00000046223 Plaur / P35456 / plasminogen activator, urokinase receptor / Q03405* / complex / reaction ENSMUSG00000021822 Plau / P06869 / plasminogen activator, urokinase / P00749* / complex / reaction
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