ENSMUSG00000021822


Mus musculus
decreasedPlauactivitycellregulationmusclereducedincreasedpeptidaseresponsemigrationfibrosislevelserinesitesmoothproteinneutrophilbodysizeliverinflammationtracheaimpairedsusceptibilitykringleegf-likedomainproteasestrypsins

Features
Gene ID: ENSMUSG00000021822
  
Biological name :Plau
  
Synonyms : P06869 / plasminogen activator, urokinase / Plau
  
Possible biological names infered from orthology : P00749
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: A3
Gene start: 20836660
Gene end: 20843385
  
Corresponding Affymetrix probe sets: 10413047 (MoGene1.0st)   1422138_at (Mouse Genome 430 2.0 Array)   1422139_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022368
Ensembl peptide - ENSMUSP00000153684
NCBI entrez gene - 18792     See in Manteia.
MGI - MGI:97611
RefSeq - XM_017315919
RefSeq - NM_008873
RefSeq Peptide - NP_032899
swissprot - P06869
swissprot - Q0VBA8
swissprot - A0A286YE40
Ensembl - ENSMUSG00000021822
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plauaENSDARG00000075265Danio rerio
 plaubENSDARG00000039145Danio rerio
 PLAUENSGALG00000005086Gallus gallus
 PLAUENSG00000122861Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Plat / P11214 / Tissue-type plasminogen activator Tissue-type plasminogen activator chain A Tissue-type plasminogen activator chain B / P00750* / plasminogen activator, tissue type*ENSMUSG0000003153840
F12 / Q80YC5 / Coagulation factor XII Coagulation factor XIIa heavy chain Coagulation factor XIIa light chain / P00748* / coagulation factor XII*ENSMUSG0000002149235
Habp2 / Mus musculus hyaluronic acid binding protein 2 (Habp2), transcript variant 1, mRNA. / Q14520* / hyaluronan binding protein 2*ENSMUSG0000002507535
Hgfac / Q9R098 / hepatocyte growth factor activator / Q04756* / HGF activator*ENSMUSG0000002910235
Plg / P20918 / Plasminogen Plasmin heavy chain A Activation peptide Angiostatin Plasmin heavy chain A, short form Plasmin light chain B / LPA* / P00747* / P08519* / plasminogen* / lipoprotein(a)*ENSMUSG0000005948130
F2 / P19221 / Prothrombin Activation peptide fragment 1 Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain / P00734* / coagulation factor II, thrombin*ENSMUSG0000002724926
Mst1 / P26928 / macrophage stimulating 1 (hepatocyte growth factor-like) / macrophage stimulating 1*ENSMUSG0000003259125
Hgf / Q08048 / Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain / P14210* / hepatocyte growth factor*ENSMUSG0000002886424


Protein motifs (from Interpro)
Interpro ID Name
 IPR000001  Kringle
 IPR000742  EGF-like domain
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR009003  Peptidase S1, PA clan
 IPR013032  EGF-like, conserved site
 IPR013806  Kringle-like fold
 IPR018056  Kringle, conserved site
 IPR033116  Serine proteases, trypsin family, serine active site
 IPR034814  Urokinase-type plasminogen activator


Gene Ontology (GO)
response to stressresponse to abiotic stimulusnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcell communicationregulation of molecular functioncellular response to stimuluslocalization of cellmovement of cell or subcellular componentcellular metabolic processcell adhesionresponse to external stimulusregulation of biological qualitycoagulationresponse to stressresponse to abiotic stimulusnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcell communicationregulation of molecular functioncellular response to stimuluslocalization of cellmovement of cell or subcellular componentcellular metabolic processcell adhesionresponse to external stimulusregulation of biological qualitycoagulationresponse to stressresponse to abiotic stimulusnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcell communicationregulation of molecular functioncellular response to stimuluslocalization of cellmovement of cell or subcellular componentcellular metabolic processcell adhesionresponse to external stimulusregulation of biological qualitycoagulationresponse to stressresponse to abiotic stimulusnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcell communicationregulation of molecular functioncellular response to stimuluslocalization of cellmovement of cell or subcellular componentcellular metabolic processcell adhesionresponse to external stimulusregulation of biological qualitycoagulationresponse to stressresponse to abiotic stimulusnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcell communicationregulation of molecular functioncellular response to stimuluslocalization of cellmovement of cell or subcellular componentcellular metabolic processcell adhesionresponse to external stimulusregulation of biological qualitycoagulationresponse to stressresponse to abiotic stimulusnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcell communicationregulation of molecular functioncellular response to stimuluslocalization of cellmovement of cell or subcellular componentcellular metabolic processcell adhesionresponse to external stimulusregulation of biological qualitycoagulationresponse to stressresponse to abiotic stimulusnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcell communicationregulation of molecular functioncellular response to stimuluslocalization of cellmovement of cell or subcellular componentcellular metabolic processcell adhesionresponse to external stimulusregulation of biological qualitycoagulationresponse to stressresponse to abiotic stimulusnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcell communicationregulation of molecular functioncellular response to stimuluslocalization of cellmovement of cell or subcellular componentcellular metabolic processcell adhesionresponse to external stimulusregulation of biological qualitycoagulationresponse to stressresponse to abiotic stimulusnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcell communicationregulation of molecular functioncellular response to stimuluslocalization of cellmovement of cell or subcellular componentcellular metabolic processcell adhesionresponse to external stimulusregulation of biological qualitycoagulationresponse to stressresponse to abiotic stimulusnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcell communicationregulation of molecular functioncellular response to stimuluslocalization of cellmovement of cell or subcellular componentcellular metabolic processcell adhesionresponse to external stimulusregulation of biological qualitycoagulationresponse response to stressresponse response to abiotic stimulusnitrogen nitrogen compound metabolic processprimary mprimary metabolic processorganic sorganic substance metabolic processcell commcell communicationregulatioregulation of molecular functioncellular cellular response to stimuluslocalizatlocalization of cellmovement movement of cell or subcellular componentcellular cellular metabolic processcell adhecell adhesionresponse response to external stimulusregulatioregulation of biological qualitycoagulaticoagulation
catalytic activity, acting on a proteinhydrolase activityprotein bindingtransferase activitycatalytic activity, acting on a proteinhydrolase activityprotein bindingtransferase activitycatalytic activity, acting on a proteinhydrolase activityprotein bindingtransferase activitycatalytic activity, acting on a proteinhydrolase activityprotein bindingtransferase activitycatalytic activity, acting on a proteinhydrolase activityprotein bindingtransferase activitycatalytic activity, acting on a proteinhydrolase activityprotein bindingtransferase activitycatalytic activity, acting on a proteinhydrolase activityprotein bindingtransferase activitycatalytic activity, acting on a proteinhydrolase activityprotein bindingtransferase activitycatalytic activity, acting on a proteinhydrolase activityprotein bindingtransferase activitycatalytic activity, acting on a proteinhydrolase activityprotein bindingtransferase activitycatalytic activity, acting on a procatalytic activity, acting on a proteinhydrolase activityhydrolase activityprotein bindingprotein bindingtransferase activitytransferase activity
extracellular regioncellextracellular regioncellextracellular regioncellextracellular regioncellextracellular regioncellextracellular regioncellextracellular regioncellextracellular regioncellextracellular regioncellextracellular regioncellextracellular regionextracellular regioncellcell
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IMP
 biological_processGO:0006508 proteolysis IBA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0014909 smooth muscle cell migration IMP
 biological_processGO:0014910 regulation of smooth muscle cell migration IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0031639 plasminogen activation ISO
 biological_processGO:0033628 regulation of cell adhesion mediated by integrin IEA
 biological_processGO:0042127 regulation of cell proliferation IGI
 biological_processGO:0042730 fibrinolysis IMP
 biological_processGO:2000097 regulation of smooth muscle cell-matrix adhesion IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0009986 cell surface IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation
Dissolution of Fibrin Clot


Phenotype (from MGI, Zfin or HPO)
cellular phenotypedigestive/alimentary phenotypemuscle phenotypegrowth/size phenotypetumorigenesisvision/eye phenotypeimmune system phenotypeliver/biliary system phenotypereproductive system phenotyperespiratory system phenotypemortality/aginghematopoietic system phenotypecardiovascular system phenotypehomeostasis/metabolism phenotypeendocrine/exocrine gland phenotypeskeleton phenotypebehavior/neurological phenotypeadipose tissue phenotypecraniofacial phenotypeintegument phenotypehearing/ear phenotypecellular phenotypedigestive/alimentary phenotypemuscle phenotypegrowth/size phenotypetumorigenesisvision/eye phenotypeimmune system phenotypeliver/biliary system phenotypereproductive system phenotyperespiratory system phenotypemortality/aginghematopoietic system phenotypecardiovascular system phenotypehomeostasis/metabolism phenotypeendocrine/exocrine gland phenotypeskeleton phenotypebehavior/neurological phenotypeadipose tissue phenotypecraniofacial phenotypeintegument phenotypehearing/ear phenotypecellular phenotypedigestive/alimentary phenotypemuscle phenotypegrowth/size phenotypetumorigenesisvision/eye phenotypeimmune system phenotypeliver/biliary system phenotypereproductive system phenotyperespiratory system phenotypemortality/aginghematopoietic system phenotypecardiovascular system phenotypehomeostasis/metabolism phenotypeendocrine/exocrine gland phenotypeskeleton phenotypebehavior/neurological phenotypeadipose tissue phenotypecraniofacial phenotypeintegument phenotypehearing/ear phenotypecellular phenotypedigestive/alimentary phenotypemuscle phenotypegrowth/size phenotypetumorigenesisvision/eye phenotypeimmune system phenotypeliver/biliary system phenotypereproductive system phenotyperespiratory system phenotypemortality/aginghematopoietic system phenotypecardiovascular system phenotypehomeostasis/metabolism phenotypeendocrine/exocrine gland phenotypeskeleton phenotypebehavior/neurological phenotypeadipose tissue phenotypecraniofacial phenotypeintegument phenotypehearing/ear phenotypecellular phenotypedigestive/alimentary phenotypemuscle phenotypegrowth/size phenotypetumorigenesisvision/eye phenotypeimmune system phenotypeliver/biliary system phenotypereproductive system phenotyperespiratory system phenotypemortality/aginghematopoietic system phenotypecardiovascular system phenotypehomeostasis/metabolism phenotypeendocrine/exocrine gland phenotypeskeleton phenotypebehavior/neurological phenotypeadipose tissue phenotypecraniofacial phenotypeintegument phenotypehearing/ear phenotypecellular phenotypedigestive/alimentary phenotypemuscle phenotypegrowth/size phenotypetumorigenesisvision/eye phenotypeimmune system phenotypeliver/biliary system phenotypereproductive system phenotyperespiratory system phenotypemortality/aginghematopoietic system phenotypecardiovascular system phenotypehomeostasis/metabolism phenotypeendocrine/exocrine gland phenotypeskeleton phenotypebehavior/neurological phenotypeadipose tissue phenotypecraniofacial phenotypeintegument phenotypehearing/ear phenotypecellular phenotypedigestive/alimentary phenotypemuscle phenotypegrowth/size phenotypetumorigenesisvision/eye phenotypeimmune system phenotypeliver/biliary system phenotypereproductive system phenotyperespiratory system phenotypemortality/aginghematopoietic system phenotypecardiovascular system phenotypehomeostasis/metabolism phenotypeendocrine/exocrine gland phenotypeskeleton phenotypebehavior/neurological phenotypeadipose tissue phenotypecraniofacial phenotypeintegument phenotypehearing/ear phenotypecellular phenotypedigestive/alimentary phenotypemuscle phenotypegrowth/size phenotypetumorigenesisvision/eye phenotypeimmune system phenotypeliver/biliary system phenotypereproductive system phenotyperespiratory system phenotypemortality/aginghematopoietic system phenotypecardiovascular system phenotypehomeostasis/metabolism phenotypeendocrine/exocrine gland phenotypeskeleton phenotypebehavior/neurological phenotypeadipose tissue phenotypecraniofacial phenotypeintegument phenotypehearing/ear phenotypecellular phenotypedigestive/alimentary phenotypemuscle phenotypegrowth/size phenotypetumorigenesisvision/eye phenotypeimmune system phenotypeliver/biliary system phenotypereproductive system phenotyperespiratory system phenotypemortality/aginghematopoietic system phenotypecardiovascular system phenotypehomeostasis/metabolism phenotypeendocrine/exocrine gland phenotypeskeleton phenotypebehavior/neurological phenotypeadipose tissue phenotypecraniofacial phenotypeintegument phenotypehearing/ear phenotypecellular phenotypedigestive/alimentary phenotypemuscle phenotypegrowth/size phenotypetumorigenesisvision/eye phenotypeimmune system phenotypeliver/biliary system phenotypereproductive system phenotyperespiratory system phenotypemortality/aginghematopoietic system phenotypecardiovascular system phenotypehomeostasis/metabolism phenotypeendocrine/exocrine gland phenotypeskeleton phenotypebehavior/neurological phenotypeadipose tissue phenotypecraniofacial phenotypeintegument phenotypehearing/ear phenotypecellulcellular phenotypedigestdigestive/alimentary phenotypemusclemuscle phenotypegrowthgrowth/size phenotypetumoritumorigenesisvisionvision/eye phenotypeimmuneimmune system phenotypeliver/liver/biliary system phenotypereprodreproductive system phenotyperespirrespiratory system phenotypemortalmortality/aginghematohematopoietic system phenotypecardiocardiovascular system phenotypehomeoshomeostasis/metabolism phenotypeendocrendocrine/exocrine gland phenotypeskeletskeleton phenotypebehavibehavior/neurological phenotypeadiposadipose tissue phenotypecraniocraniofacial phenotypeinteguintegument phenotypehearinhearing/ear phenotype
IDPhenotypeDefinition Genetic BG
 MP:0000316 cellular necrosis "pathologic death of cells, usually from irreversible damage" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hoxa9tm1Mrc/Hoxa9tm1Mrc,Hoxb9tm1Mrc/Hoxb9+,Hoxd9tm1Mrc/Hoxd9tm1Mrc
Genetic Background: Not Specified

 MP:0000492 abnormal rectum morphology "structural aberration in the terminal portion of the intestinal tube adjacent to the anus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Cxcr4tm2Yzo/Cxcr4tm2Yzo
Genetic Background: involves: 129P2/OlaHsd

 MP:0000493 rectal prolapse "downward movement and external appearance of the rectum through the anus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

Allelic Composition: Plattm1Mlg/Plattm1Mlg,Plautm1Mlg/Plautm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Plautm1Mlg/Plautm1Mlg
Genetic Background: B6.Cg-Plautm1Mlg

 MP:0000751 myopathy "any abnormal condition or disease of the skeletal muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:42574]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Cxcr4tm2Yzo/Cxcr4tm2Yzo
Genetic Background: involves: 129P2/OlaHsd

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Hoxa9tm1Mrc/Hoxa9tm1Mrc,Hoxb9tm1Mrc/Hoxb9+,Hoxd9tm1Mrc/Hoxd9tm1Mrc
Genetic Background: Not Specified

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Hoxa9tm1Mrc/Hoxa9tm1Mrc,Hoxb9tm1Mrc/Hoxb9+,Hoxd9tm1Mrc/Hoxd9tm1Mrc
Genetic Background: Not Specified

 MP:0001273 decreased metastatic potential 
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Allelic Composition: Plautm1Mlg/Plautm1Mlg
Genetic Background: B6.Cg-Plautm1Mlg

 MP:0001340 abnormal eyelid morphology "malformation of the skin folds covering the front of the eyeball" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

Allelic Composition: Plattm1Mlg/Plattm1Mlg,Plautm1Mlg/Plautm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Plattm1Mlg/Plattm1Mlg,Plautm1Mlg/Plautm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Plautm1Mlg/Plautm1Mlg
Genetic Background: B6.129S2-Plautm1Mlg

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ncor2Gt(RRM275)Byg/Ncor2+
Genetic Background: B6.129P2-Ncor2Gt(RRM275)Byg

Allelic Composition: Plautm1Mlg/Plautm1Mlg
Genetic Background: B6.129S2-Plautm1Mlg

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Cxcr4tm2Yzo/Cxcr4tm2Yzo
Genetic Background: involves: 129P2/OlaHsd

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Plattm1Mlg/Plattm1Mlg,Plautm1Mlg/Plautm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Plattm1Mlg/Plattm1Mlg,Plautm1Mlg/Plautm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Plattm1Mlg/Plattm1Mlg,Plautm1Mlg/Plautm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002038 carcinoma "malignant neoplasm arising from epithelial cells, usually glandular or squamous" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Zbtb32tm2Ppp/Zbtb32tm2Ppp
Genetic Background: involves: 129S1/Sv

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hoxa9tm1Mrc/Hoxa9tm1Mrc,Hoxb9tm1Mrc/Hoxb9+,Hoxd9tm1Mrc/Hoxd9tm1Mrc
Genetic Background: Not Specified

Allelic Composition: Plautm1Mlg/Plautm1Mlg
Genetic Background: B6.129S2-Plautm1Mlg

 MP:0002282 abnormal trachea morphology "structral anomaly of the tube descending from the larynx and branching into the right and left main bronchi" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Plautm1Mlg/Plautm1Mlg
Genetic Background: B6.129S2-Plautm1Mlg

 MP:0002421 abnormal cell-mediated immunity "abnormal function of any adaptive immune response in which T cells play a main role " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0002467 impaired neutrophil phagocytosis "reduced ability of these leukocytes to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0002499 chronic inflammation "persistent inflammatory response, often caused by persistent infection or during an autoimmune response" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ncor2Gt(RRM275)Byg/Ncor2+
Genetic Background: B6.129P2-Ncor2Gt(RRM275)Byg

Allelic Composition: Plautm1Mlg/Plautm1Mlg
Genetic Background: B6.129S2-Plautm1Mlg

 MP:0002625 left ventricle hypertrophy "increased size of the left ventricle" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0002964 aortic elastic tissue lesions "focal pathological changes in the elastic lamella of the muscular layer of the main trunk of the arterial system" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Bres/Apoetm1Bres,Plautm1Mlg/Plautm1Mlg
Genetic Background: involves: 129 * C57BL/6

 MP:0003315 abnormal perineum morphology "malformation in the area between the genital organs and the anus that lies beneath the pelvic diaphragm" [ncbi:Matthew Mailman, NCBI request, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Plautm1Mlg/Plautm1Mlg
Genetic Background: B6.Cg-Plautm1Mlg

 MP:0003333 liver fibrosis "invasion of fibrous connective tissue into the liver, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Ncor2Gt(RRM275)Byg/Ncor2+
Genetic Background: B6.129P2-Ncor2Gt(RRM275)Byg

Allelic Composition: Plautm1Mlg/Plautm1Mlg
Genetic Background: B6.129S2-Plautm1Mlg

 MP:0003423 reduced thrombolysis "reduced ability or inability to break up (lyse) blood clots that are restricting the blood flow" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:17427]
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Allelic Composition: Plattm1Mlg/Plattm1Mlg,Plautm1Mlg/Plautm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Plautm1Mlg/Plautm1Mlg
Genetic Background: either: B6.Cg-Plautm1Mlg or (involves: Black Swiss * C57BL/6)

 MP:0003426 pulmonary interstitial fibrosis "formation of fibrous tissue within the interstices of the lung as a result of repair or a reactive process" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:63134]
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Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0003434 resistance to induced choroidal neovascularization "reduction or absence of growth of new, abnormal blood vessels that originate in the choroid through a break in the Bruch membrane into the sub-retinal pigment epithelium or subretinal space and may result in visual loss as a result of chemical or mechanical manipulation (e.g. laser-induced trauma)" [J:82604, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0003435 herniated seminal glands "protrusion of the seminal vesicles through the pelvic outlet" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:73613]
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Allelic Composition: Plautm1Mlg/Plautm1Mlg
Genetic Background: B6.Cg-Plautm1Mlg

 MP:0003436 resistance to induced arthritis "less likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:75303]
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Allelic Composition: Plautm1Mlg/Plautm1Mlg
Genetic Background: B6.Cg-Plautm1Mlg

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
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Allelic Composition: Plautm1Mlg/Plautm1Mlg
Genetic Background: B6.Cg-Plautm1Mlg

 MP:0003448 altered tumor morphology "changes in the expected pathology for a given tumor type compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Plautm1Mlg/Plautm1Mlg
Genetic Background: B6.Cg-Plautm1Mlg

 MP:0003799 impaired macrophage migration "defect in the ability of macrophages to move up a chemotactic gradient" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

Allelic Composition: Plautm1Mlg/Plautm1Mlg
Genetic Background: B6.Cg-Plautm1Mlg

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pik3c2atm1b(EUCOMM)Hmgu/Pik3c2a+
Genetic Background: C57BL/6N-Pik3c2atm1b(EUCOMM)Hmgu/Tcp

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0005048 thrombosis "formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

Allelic Composition: Plattm1Mlg/Plattm1Mlg,Plautm1Mlg/Plautm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005074 defective granulocyte bactericidal activity "inability or reduced ability of neutrophils, eosinophils, or basophils to kill bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:5405]
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Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Plautm1Mlg/Plautm1Mlg
Genetic Background: B6.Cg-Plautm1Mlg

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Plattm1Mlg/Plattm1Mlg,Plautm1Mlg/Plautm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Plautm1Mlg/Plautm1Mlg
Genetic Background: B6.129S2-Plautm1Mlg

 MP:0005164 abnormal response to injury "anomaly in the body s reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Plautm1Mlg/Plautm1Mlg
Genetic Background: B6.129S2-Plautm1Mlg

 MP:0005341 decreased susceptibility to atherosclerosis "less likely than the norm to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Zbtb32tm2Ppp/Zbtb32tm2Ppp
Genetic Background: involves: 129S1/Sv

 MP:0005399 increased susceptibility to fungal infection "greater likelihood that an organism will develop ill effects from infection by a yeast or mold, or from components of, or toxins produced by, these organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0005416 abnormal circulating protein level "anomalous blood concentration of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0005600 increased ventricle muscle contractility "greater thant the normal ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0005608 cardiac interstitial fibrosis "formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Plautm1Mlg/Plautm1Mlg
Genetic Background: B6.Cg-Plautm1Mlg

 MP:0008762 embryonic lethality "death of an animal in the embryonic period (Mus: up to E14)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Thbdtm1Wlr/Thbdtm2Rdr
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ncor2Gt(RRM275)Byg/Ncor2+
Genetic Background: B6.129P2-Ncor2Gt(RRM275)Byg

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Plautm1Mlg/Plautm1Mlg
Genetic Background: B6.129S2-Plautm1Mlg

 MP:0010211 abnormal acute phase protein level "deviation from the normal levels of the series of proteins found in the blood shortly after infection and which participate in the early phases of host defense against infection" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

Allelic Composition: Plautm1Mlg/Plautm1Mlg
Genetic Background: B6.Cg-Plautm1Mlg

 MP:0010398 decreased liver glycogen level "less than the normal concentration of a readily converted carbohydrate reserve in liver" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Plautm1Mlg/Plautm1Mlg
Genetic Background: B6.129S2-Plautm1Mlg

 MP:0013239 impaired skeletal muscle regeneration "reduced ability to repair skeletal muscle after injury or disease" [MGI:csmith]
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Allelic Composition: Plautm1Mlg/Plautm1Mlg
Genetic Background: B6.Cg-Plautm1Mlg

 MP:0013498 trachea inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the trachea" [MGI:Anna]
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Allelic Composition: Ncor2Gt(RRM275)Byg/Ncor2+
Genetic Background: B6.129P2-Ncor2Gt(RRM275)Byg

Allelic Composition: Plautm1Mlg/Plautm1Mlg
Genetic Background: B6.129S2-Plautm1Mlg

 MP:0013499 trachea fibrosis "invasion of fibrous connective tissue into the trachea, often resulting from inflammation or injury" [MGI:Anna]
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Allelic Composition: Plautm1Mlg/Plautm1Mlg
Genetic Background: B6.129S2-Plautm1Mlg

 MP:0030530 abnormal outer ear skin morphology "any anomaly in a zone of skin that is part of an outer ear" [UBERON:0001459]
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Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

Allelic Composition: Plattm1Mlg/Plattm1Mlg,Plautm1Mlg/Plautm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0030531 abnormal facial skin morphology "any anomaly in a zone of skin that is part of the face" [UBERON:1000021]
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Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

Allelic Composition: Plattm1Mlg/Plattm1Mlg,Plautm1Mlg/Plautm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000046223 Plaur / P35456 / plasminogen activator, urokinase receptor / Q03405*  / complex / reaction
 ENSMUSG00000059481 Plg / P20918 / Plasminogen Plasmin heavy chain A Activation peptide Angiostatin Plasmin heavy chain A, short form Plasmin light chain B / LPA* / P00747* / P08519* / plasminogen* / lipoprotein(a)*  / reaction
 ENSMUSG00000062345 P12388 / Serpinb2 / serine (or cysteine) peptidase inhibitor, clade B, member 2 / P05120* / serpin family B member 2*  / complex / reaction
 ENSMUSG00000021822 Plau / P06869 / plasminogen activator, urokinase / P00749*  / complex
 ENSMUSG00000022877 Hrg / histidine rich glycoprotein / P04196*  / reaction
 ENSMUSG00000037411 Serpine1 / serine (or cysteine) peptidase inhibitor, clade E, member 1 / P05121* / serpin family E member 1*  / complex / reaction






 

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