ENSMUSG00000062713


Mus musculus

Features
Gene ID: ENSMUSG00000062713
  
Biological name :Sim2
  
Synonyms : Q61079 / Sim2 / Single-minded homolog 2
  
Possible biological names infered from orthology : Q14190 / single-minded family bHLH transcription factor 2
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: C4
Gene start: 94085260
Gene end: 94127032
  
Corresponding Affymetrix probe sets: 10437055 (MoGene1.0st)   1419437_at (Mouse Genome 430 2.0 Array)   1419438_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000072043
NCBI entrez gene - 20465     See in Manteia.
MGI - MGI:98307
RefSeq - XM_017316897
RefSeq - NM_011377
RefSeq - XM_006522967
RefSeq - XM_006522968
RefSeq - XM_006522966
RefSeq Peptide - NP_035507
swissprot - Q61079
Ensembl - ENSMUSG00000062713
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SIM2ENSGALG00000016044Gallus gallus
 SIM2ENSG00000159263Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sim1 / Q61045 / Single-minded homolog 1 / P81133* / single-minded family bHLH transcription factor 1*ENSMUSG0000001991360
Npas3 / neuronal PAS domain protein 3 / Q8IXF0*ENSMUSG0000002101033
Npas1 / P97459 / Neuronal PAS domain-containing protein 1 / Q99742* / neuronal PAS domain protein 1*ENSMUSG0000000198827
Hif1a / Q61221 / Hypoxia-inducible factor 1-alpha / Q16665* / hypoxia inducible factor 1 alpha subunit*ENSMUSG0000002110927
Epas1 / P97481 / Endothelial PAS domain-containing protein 1 / Q99814* / endothelial PAS domain protein 1*ENSMUSG0000002414026
Hif3a / Q0VBL6 / Hypoxia-inducible factor 3-alpha / Q9Y2N7* / hypoxia inducible factor 3 alpha subunit*ENSMUSG0000000432824
Npas2 / neuronal PAS domain protein 2 / Q99743*ENSMUSG0000002607718
Arnt / P53762 / Aryl hydrocarbon receptor nuclear translocator / P27540*ENSMUSG0000001552216
Arnt2 / Q61324 / Aryl hydrocarbon receptor nuclear translocator 2 / Q9HBZ2*ENSMUSG0000001570916
Clock / O08785 / Circadian locomoter output cycles protein kaput / O15516* / clock circadian regulator*ENSMUSG0000002923816
Arntl / Q9WTL8 / Mus musculus aryl hydrocarbon receptor nuclear translocator-like (Arntl), transcript variant 3, mRNA. / O00327* / aryl hydrocarbon receptor nuclear translocator like*ENSMUSG0000005511616
Arntl2 / Q2VPD4 / Aryl hydrocarbon receptor nuclear translocator-like protein 2 / Q8WYA1* / aryl hydrocarbon receptor nuclear translocator like 2*ENSMUSG0000004018714


Protein motifs (from Interpro)
Interpro ID Name
 IPR000014  PAS domain
 IPR001610  PAC motif
 IPR010578  Single-minded, C-terminal
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR013655  PAS fold-3
 IPR013767  PAS fold
 IPR035965  PAS domain superfamily
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IGI
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IBA
 biological_processGO:0009880 embryonic pattern specification IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030324 lung development IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0016604 nuclear body IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046982 protein heterodimerization activity IPI
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000116 abnormal tooth development "anomalous formation of the teeth" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Egfl7tm1Wye/Egfl7tm1Wye
Genetic Background: B6.129-Egfl7tm1Wye

 MP:0000778 abnormal tract 
Show

Allelic Composition: Tdgf1tm2Mms/Tdgf1tm2.1Mms
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Sim1tm1Fan/Sim1tm1Fan,Sim2tm1Fan/Sim2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Sim1tm1Fan/Sim1+,Sim2tm1Fan/Sim2tm1Fan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Sim1tm1Jlmd/Sim1tm1Jlmd,Sim2tm1Fan/Sim2tm1Fan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000830 abnormal diencephalon morphology "any malformation or absence of the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Sim1tm1Fan/Sim1+,Sim2tm1Fan/Sim2+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Egfl7tm1Wye/Egfl7tm1Wye
Genetic Background: B6.129-Egfl7tm1Wye

 MP:0002251 abnormal nasopharynx morphology "structural anomaly of the section of the pharynx that lies above the soft palate" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Egfl7tm1Wye/Egfl7tm1Wye
Genetic Background: B6.129-Egfl7tm1Wye

 MP:0003755 abnormal palate "anomaly in the roof of the mouth in vertebrates formed anteriorly by a bony projection of the upper jaw (hard palate) and posteriorly by the fold of connective tissue (soft palate) " [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Egfl7tm1Wye/Egfl7tm1Wye
Genetic Background: B6.129-Egfl7tm1Wye

 MP:0003760 short palate "abnormally decreased length to the roof of the oral cavity" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Egfl7tm1Wye/Egfl7tm1Wye
Genetic Background: B6.129-Egfl7tm1Wye

 MP:0004452 abnormal pterygoid process morphology "any structural anomaly of the process projecting downward from either side of the sphenoid bone, in vertebrates divided into two plates, an inner and an outer (sometimes called the lateral and medial); the posterior nares pass through the space, called the pterygoid fossa, between the processes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Egfl7tm1Wye/Egfl7tm1Wye
Genetic Background: B6.129-Egfl7tm1Wye

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sim1tm1Jlmd/Sim1tm1Jlmd,Sim2tm1Fan/Sim2tm1Fan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005455 increased weight gain "greater increase in body weight over existing weight when compared to the average increase in weight on the same diet, with equal energy (calorie) intake " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:42702]
Show

Allelic Composition: Sim1tm1Fan/Sim1+,Sim2tm1Fan/Sim2+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0009247 meteorism "swelling of the abdomen resulting from gas in the intestinal or peritoneal cavity" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Egfl7tm1Wye/Egfl7tm1Wye
Genetic Background: B6.129-Egfl7tm1Wye

 MP:0009883 palatal shelf hypoplasia "reduced size of the palatal projections from the inner part of the maxillary processes that fuse to form the secondary palate, often due to reduced cell number" [PMID:16680722]
Show

Allelic Composition: Egfl7tm1Wye/Egfl7tm1Wye
Genetic Background: B6.129-Egfl7tm1Wye

 MP:0009890 cleft secondary palate "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]
Show

Allelic Composition: Egfl7tm1Wye/Egfl7tm1Wye
Genetic Background: B6.129-Egfl7tm1Wye

 MP:0009908 protruding tongue "the tongue extends out beyond the oral cavity past the lips; may be due to paralysis, oral cavity size, tongue hypoplasia or dysfunction of the hypoglossal nerve" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Egfl7tm1Wye/Egfl7tm1Wye
Genetic Background: B6.129-Egfl7tm1Wye

 MP:0010994 aerophagia "excessive swallowing of air or gas" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Egfl7tm1Wye/Egfl7tm1Wye
Genetic Background: B6.129-Egfl7tm1Wye

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Egfl7tm1Wye/Egfl7tm1Wye
Genetic Background: B6.129-Egfl7tm1Wye

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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