Manteia

ENSMUSG00000019913

Mus musculus

Features

Gene ID:	ENSMUSG00000019913

Biological name :	Sim1

Synonyms :	Q61045 / Sim1 / Single-minded homolog 1

Possible biological names infered from orthology :	P81133 / single-minded family bHLH transcription factor 1

Species:	Mus musculus

Chr. number:	10
Strand:	1
Band:	B3
Gene start:	50894754
Gene end:	50989152

Corresponding Affymetrix probe sets:	10363056 (MoGene1.0st) 1420736_at (Mouse Genome 430 2.0 Array) 1449967_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000020071 Ensembl peptide - ENSMUSP00000151816 NCBI entrez gene - 20464 See in Manteia. MGI - MGI:98306 RefSeq - XM_006512632 RefSeq - NM_011376 RefSeq - XM_006512629 RefSeq - XM_006512630 RefSeq - XM_006512631 RefSeq - XM_006512626 RefSeq - XM_006512627 RefSeq - XM_006512628 RefSeq Peptide - NP_035506 swissprot - Q61045 swissprot - A0A1W2P7V8 Ensembl - ENSMUSG00000019913

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
sim1a	ENSDARG00000023316	Danio rerio
sim1b	ENSDARG00000013789	Danio rerio
SIM1	ENSGALG00000015466	Gallus gallus
SIM1	ENSG00000112246	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Sim2 / Q61079 / Single-minded homolog 2 / Q14190* / single-minded family bHLH transcription factor 2*	ENSMUSG00000062713	51
Npas3 / neuronal PAS domain protein 3 / Q8IXF0*	ENSMUSG00000021010	29
Npas1 / P97459 / Neuronal PAS domain-containing protein 1 / Q99742* / neuronal PAS domain protein 1*	ENSMUSG00000001988	24
Hif1a / Q61221 / Hypoxia-inducible factor 1-alpha / Q16665* / hypoxia inducible factor 1 alpha subunit*	ENSMUSG00000021109	23
Epas1 / P97481 / Endothelial PAS domain-containing protein 1 / Q99814* / endothelial PAS domain protein 1*	ENSMUSG00000024140	23
Hif3a / Q0VBL6 / Hypoxia-inducible factor 3-alpha / Q9Y2N7* / hypoxia inducible factor 3 alpha subunit*	ENSMUSG00000004328	21
Arnt / P53762 / Aryl hydrocarbon receptor nuclear translocator / P27540*	ENSMUSG00000015522	15
Arnt2 / Q61324 / Aryl hydrocarbon receptor nuclear translocator 2 / Q9HBZ2*	ENSMUSG00000015709	15
Npas2 / neuronal PAS domain protein 2 / Q99743*	ENSMUSG00000026077	14
Clock / O08785 / Circadian locomoter output cycles protein kaput / O15516* / clock circadian regulator*	ENSMUSG00000029238	14
Arntl / Q9WTL8 / Mus musculus aryl hydrocarbon receptor nuclear translocator-like (Arntl), transcript variant 3, mRNA. / O00327* / aryl hydrocarbon receptor nuclear translocator like*	ENSMUSG00000055116	14
Arntl2 / Q2VPD4 / Aryl hydrocarbon receptor nuclear translocator-like protein 2 / Q8WYA1* / aryl hydrocarbon receptor nuclear translocator like 2*	ENSMUSG00000040187	13

Protein motifs (from Interpro)

Interpro ID	Name
IPR000014	PAS domain
IPR001610	PAC motif
IPR010578	Single-minded, C-terminal
IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
IPR013655	PAS fold-3
IPR013767	PAS fold
IPR035965	PAS domain superfamily
IPR036638	Helix-loop-helix DNA-binding domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001657	ureteric bud development	IEP
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IDA
biological_process	GO:0006357	regulation of transcription by RNA polymerase II	IBA
biological_process	GO:0007275	multicellular organism development	IEA
biological_process	GO:0007399	nervous system development	IBA
biological_process	GO:0030154	cell differentiation	IEA
cellular_component	GO:0005634	nucleus	IDA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
molecular_function	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	IBA
molecular_function	GO:0003677	DNA binding	IEA
molecular_function	GO:0003700	DNA-binding transcription factor activity	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0046982	protein heterodimerization activity	IPI
molecular_function	GO:0046983	protein dimerization activity	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000005	increased brown fat amount	"increased amount of thermogenic tissue in the body that is composed of cells containing multiple small fat droplets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:14208]	Show Allelic Composition: Elk4^tm1Rtr/Elk4^tm1Rtr,Tg(TcraTcrb)425Cbn/? Genetic Background: involves: 129/Sv * C57BL/6
MP:0000008	increased white fat amount	"increased quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Elk4^tm1Rtr/Elk4^tm1Rtr,Tg(TcraTcrb)425Cbn/? Genetic Background: involves: 129/Sv * C57BL/6
MP:0000778	abnormal tract		Show Allelic Composition: Tdgf1^tm2Mms/Tdgf1^tm2.1Mms Genetic Background: involves: 129S6/SvEvTac * C57BL/6 Allelic Composition: Sim1^tm1Fan/Sim1^tm1Fan,Sim2^tm1Fan/Sim2^tm1Fan Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Sim1^tm1Fan/Sim1^tm1Fan,Sim2^tm1Fan/Sim2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Sim1^tm1Fan/Sim1⁺,Sim2^tm1Fan/Sim2^tm1Fan Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Sim1^tm1Jlmd/Sim1^tm1Jlmd Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Sim1^tm1Jlmd/Sim1^tm1Jlmd,Sim2^tm1Fan/Sim2^tm1Fan Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0000830	abnormal diencephalon morphology	"any malformation or absence of the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Elk4^tm1Rtr/Elk4^tm1Rtr,Tg(TcraTcrb)425Cbn/? Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Sim1^tm1Fan/Sim1⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Sim1^tm1Fan/Sim1⁺,Sim2^tm1Fan/Sim2⁺ Genetic Background: involves: 129/Sv * C57BL/6
MP:0000837	abnormal hypothalamus morphology	"any malformation or absence of the ventral part of the diencephalon extending from the region of the optic chiasm to the caudal border of the mammillary bodies and forming the inferior and lateral walls of the third ventricle; this region regulates the autonomic nervous system via hormone production and release" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Sim1^tm1Jlmd/Sim1^tm1Jlmd Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0001257	increased body length	"increased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]	Show Allelic Composition: Elk4^tm1Rtr/Elk4^tm1Rtr,Tg(TcraTcrb)425Cbn/? Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Sim1^tm1.1Az/Sim1⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB
MP:0001260	increased body weight	"greater than normal average weight " [J:33400]	Show Allelic Composition: Sim1^tm1.1Az/Sim1⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB
MP:0001261	obese	"excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Sim1^tm1.1Az/Sim1⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB Allelic Composition: Sim1^Rgsc646/Sim1⁺ Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl
MP:0001406	abnormal gait	"unusual or distinctive way of walking" [J:65038]	Show Allelic Composition: Gt(ROSA)26Sor^{tm2(GFP/tetX)Gld}/Gt(ROSA)26Sor⁺,Sim1^{tm1.1(cre)Gld}/Sim1⁺ Genetic Background: involves: C57BL/6 * SJL
MP:0001433	polyphagia	"eating to excess" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Elk4^tm1Rtr/Elk4^tm1Rtr,Tg(TcraTcrb)425Cbn/? Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Sim1^tm1.1Az/Sim1⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB
MP:0001559	hyperglycemia	"abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Sim1^Rgsc646/Sim1⁺ Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl
MP:0001759	increased urine glucose level	"a greater level of excretion of glucose in the urine compared to the normal state" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Sim1^Rgsc646/Sim1⁺ Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl
MP:0002058	neonatal lethality	"death of animal within one day after birth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Sim1^tm1Fan/Sim1⁺,Sim2^tm1Fan/Sim2^tm1Fan Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0002078	abnormal glucose homeostasis	"anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Elk4^tm1Rtr/Elk4^tm1Rtr,Tg(TcraTcrb)425Cbn/? Genetic Background: involves: 129/Sv * C57BL/6
MP:0002079	increased circulating insulin level	"greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Elk4^tm1Rtr/Elk4^tm1Rtr,Tg(TcraTcrb)425Cbn/? Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Sim1^tm1.1Az/Sim1⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB Allelic Composition: Sim1^Rgsc646/Sim1⁺ Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Itgb2^tm2Bay/Itgb2^tm2Bay Genetic Background: B6.129S7-Itgb2^tm2Bay
MP:0002206	abnormal CNS synaptic transmission	"defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Gt(ROSA)26Sor^{tm2(GFP/tetX)Gld}/Gt(ROSA)26Sor⁺,Sim1^{tm1.1(cre)Gld}/Sim1⁺ Genetic Background: involves: C57BL/6 * SJL Allelic Composition: Sim1^{tm1.1(cre)Gld}/Sim1⁺,Tg(CAG-Bgeo,-AlstR,-EGFP)192Gld/0 Genetic Background: involves: 129S1/Sv * C57BL/6 * SJL
MP:0002659	pituitary gland hypoplasia	"decreased size of pituitary gland due to decreased cell number" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Elk4^tm1Rtr/Elk4^tm1Rtr,Tg(TcraTcrb)425Cbn/? Genetic Background: involves: 129/Sv * C57BL/6
MP:0002970	abnormal white fat morphology	"structural aberration in the connective tissue consisting of fat-storing cells and arranged in lobular groups or along minor blood vessels" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Sim1^tm1Fan/Sim1⁺ Genetic Background: involves: 129/Sv * C57BL/6
MP:0002971	abnormal brown fat morphology	"defect in the thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Sim1^tm1Fan/Sim1⁺ Genetic Background: involves: 129/Sv * C57BL/6
MP:0005331	insulin resistance	"diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Sim1^Rgsc646/Sim1⁺ Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl
MP:0005404	abnormal axon morphology	"anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Sim1^tm1Jlmd/Sim1^tm1Jlmd,Sim2^tm1Fan/Sim2^tm1Fan Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0005448	abnormal energy balance	"aberrant intake or expenditure of calories as compared to the normal state" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Sim1^tm1.1Az/Sim1⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB
MP:0005455	increased weight gain	"greater increase in body weight over existing weight when compared to the average increase in weight on the same diet, with equal energy (calorie) intake " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:42702]	Show Allelic Composition: Sim1^tm1Fan/Sim1⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Sim1^tm1Fan/Sim1⁺,Sim2^tm1Fan/Sim2⁺ Genetic Background: involves: 129/Sv * C57BL/6
MP:0005559	increased circulating glucose level	"greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]	Show Allelic Composition: Sim1^tm1.1Az/Sim1⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB
MP:0005658	susceptibility to diet-induced obesity	"more likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]	Show Allelic Composition: Sim1^tm1.1Az/Sim1⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB
MP:0005669	increased circulating leptin level	"greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]	Show Allelic Composition: Sim1^tm1.1Az/Sim1⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB
MP:0006009	abnormal neuronal migration	"defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Sim1^tm1Jlmd/Sim1^tm1Jlmd Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0006043	decreased apoptosis	"less than normal cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Sim1^tm1Jlmd/Sim1^tm1Jlmd Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0006353	incleased glycosylated hemoglobin level	"greater than normal blood concentration of a modified form of hemoglobin with an attached saccharide molecule " [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator", Riken ENU:Hiroshi Masuya]	Show Allelic Composition: Sim1^Rgsc646/Sim1⁺ Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl
MP:0008845	abnormal paraventricular hypothalamic nucleus morphology	"any structural anomaly of a group of magnocellular neurons located in the periventricular zone of the anterior half of the hypothalamus" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Elk4^tm1Rtr/Elk4^tm1Rtr,Tg(TcraTcrb)425Cbn/? Genetic Background: involves: 129/Sv * C57BL/6
MP:0008846	abnormal supraoptic nucleus morphology	"any structural anomaly of a group of cells in the hypothalamus located over the lateral border of the optic tract; neurons produce and transport vasopressin" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Elk4^tm1Rtr/Elk4^tm1Rtr,Tg(TcraTcrb)425Cbn/? Genetic Background: involves: 129/Sv * C57BL/6
MP:0009468	absent magnocellular neurosecretory cells	"absence of the cells residing mainly in the hypothalamic supraoptic and paraventricular nuclei and in a number of smaller accessory cell groups between these two nuclei, and secrete the hormones oxytocin and vasopressin" [PMID:10711808]	Show Allelic Composition: Elk4^tm1Rtr/Elk4^tm1Rtr,Tg(TcraTcrb)425Cbn/? Genetic Background: involves: 129/Sv * C57BL/6
MP:0010024	increased total body fat amount	"greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sim1^tm1.1Az/Sim1⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB
MP:0011087	complete neonatal lethality	"death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Elk4^tm1Rtr/Elk4^tm1Rtr,Tg(TcraTcrb)425Cbn/? Genetic Background: involves: 129/Sv * C57BL/6
MP:0013340	abnormal pituicyte morphology	"any structural anomaly of the distinctive fusiform cells present in the pars nervosa of the posterior pituitary gland which resemble astrocytes/glial cells of the CNS and assist in the storage and release of neurohypophysial hormones" [MGI:Anna]	Show Allelic Composition: Elk4^tm1Rtr/Elk4^tm1Rtr,Tg(TcraTcrb)425Cbn/? Genetic Background: involves: 129/Sv * C57BL/6

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

External programs and data are copyrighted by and are the property of their respective authors. The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation
		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr