ENSMUSG00000064179


Mus musculus

Features
Gene ID: ENSMUSG00000064179
  
Biological name :Tnnt1
  
Synonyms : O88346 / Tnnt1 / troponin T1, skeletal, slow
  
Possible biological names infered from orthology : P13805 / troponin T1, slow skeletal type
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: A1
Gene start: 4504570
Gene end: 4516382
  
Corresponding Affymetrix probe sets: 10559547 (MoGene1.0st)   1419606_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000128476
Ensembl peptide - ENSMUSP00000127964
Ensembl peptide - ENSMUSP00000129109
Ensembl peptide - ENSMUSP00000137198
Ensembl peptide - ENSMUSP00000132012
Ensembl peptide - ENSMUSP00000129626
Ensembl peptide - ENSMUSP00000129409
Ensembl peptide - ENSMUSP00000071704
Ensembl peptide - ENSMUSP00000104228
Ensembl peptide - ENSMUSP00000125795
NCBI entrez gene - 21955     See in Manteia.
MGI - MGI:1333868
RefSeq - XM_017322114
RefSeq - NM_001277903
RefSeq - NM_001277904
RefSeq - NM_011618
RefSeq - XM_006539726
RefSeq - XM_011250477
RefSeq - XM_011250478
RefSeq - XM_017322111
RefSeq - XM_017322112
RefSeq - XM_017322113
RefSeq Peptide - NP_001264832
RefSeq Peptide - NP_001264833
RefSeq Peptide - NP_035748
swissprot - E9QA86
swissprot - E9Q688
swissprot - E9Q334
swissprot - E9Q0G9
swissprot - J3QPC8
swissprot - E9PZB4
swissprot - O88346
swissprot - Q3TVB8
swissprot - E9PVN9
Ensembl - ENSMUSG00000064179
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tnnt1ENSDARG00000037954Danio rerio
 TNNT1ENSG00000105048Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tnnt3 / troponin T3, skeletal, fast / P45378* / troponin T3, fast skeletal type*ENSMUSG0000006172360
Tnnt2 / P50752 / Troponin T, cardiac muscle / P45379* / troponin T2, cardiac type*ENSMUSG0000002641458


Protein motifs (from Interpro)
Interpro ID Name
 IPR001978  Troponin
 IPR027707  Troponin T


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003009 skeletal muscle contraction ISO
 biological_processGO:0006937 regulation of muscle contraction IEA
 biological_processGO:0014883 transition between fast and slow fiber IDA
 biological_processGO:0031444 slow-twitch skeletal muscle fiber contraction IEA
 biological_processGO:0045932 negative regulation of muscle contraction ISO
 cellular_componentGO:0005861 troponin complex IEA
 molecular_functionGO:0005523 tropomyosin binding ISO
 molecular_functionGO:0031014 troponin T binding IEA


Pathways (from Reactome)
Pathway description
Striated Muscle Contraction


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Flot1tm1.1Arte/Flot1tm1.1Arte,Flot2Gt(258D8)Cmhd/Flot2Gt(258D8)Cmhd,Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Tnnt1tm1.2Jin/Tnnt1tm1.2Jin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004036 abnormal muscle relaxation "altered ability of the muscle to lengthen following contractions" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Flot1tm1.1Arte/Flot1tm1.1Arte,Flot2Gt(258D8)Cmhd/Flot2Gt(258D8)Cmhd,Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Tnnt1tm1.2Jin/Tnnt1tm1.2Jin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004087 abnormal muscle fiber morphology "malformed or poorly developed muscle fibers, the cylindrical multinucleated muscle cells that contract when stimulated" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Flot1tm1.1Arte/Flot1tm1.1Arte,Flot2Gt(258D8)Cmhd/Flot2Gt(258D8)Cmhd,Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Tnnt1tm1.2Jin/Tnnt1tm1.2Jin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005620 abnormal muscle contractility "aberrant ability of a muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Flot1tm1.1Arte/Flot1tm1.1Arte,Flot2Gt(258D8)Cmhd/Flot2Gt(258D8)Cmhd,Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Tnnt1tm1.2Jin/Tnnt1tm1.2Jin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009400 decreased skeletal muscle fiber size "decrease in the size of the large multinucleated cells that make up the skeletal muscles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Flot1tm1.1Arte/Flot1tm1.1Arte,Flot2Gt(258D8)Cmhd/Flot2Gt(258D8)Cmhd,Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Tnnt1tm1.2Jin/Tnnt1tm1.2Jin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009401 increased skeletal muscle fiber diameter "increased width of the cross-sectional distance that extends from one lateral edge of a skeletal muscle fiber, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Flot1tm1.1Arte/Flot1tm1.1Arte,Flot2Gt(258D8)Cmhd/Flot2Gt(258D8)Cmhd,Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Tnnt1tm1.2Jin/Tnnt1tm1.2Jin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009402 decreased skeletal muscle fiber diameter "decreased width of the cross-sectional distance that extends from one lateral edge of a skeletal muscle fiber, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Flot1tm1.1Arte/Flot1tm1.1Arte,Flot2Gt(258D8)Cmhd/Flot2Gt(258D8)Cmhd,Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Tnnt1tm1.2Jin/Tnnt1tm1.2Jin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009404 centrally nucleated skeletal muscle fibers "cell nuclei are located at a position in the center of the skeletal myofiber, instead of their normal location at the periphery of the fiber; may be indicative of centronuclear myopathy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Flot1tm1.1Arte/Flot1tm1.1Arte,Flot2Gt(258D8)Cmhd/Flot2Gt(258D8)Cmhd,Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Tnnt1tm1.2Jin/Tnnt1tm1.2Jin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009409 abnormal skeletal muscle fiber type ratio "deviation from the standard ratios of fiber types in a given skeletal muscle compared to control samples" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Flot1tm1.1Arte/Flot1tm1.1Arte,Flot2Gt(258D8)Cmhd/Flot2Gt(258D8)Cmhd,Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Tnnt1tm1.2Jin/Tnnt1tm1.2Jin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009413 skeletal muscle fiber atrophy "a wasting of skeletal muscle fibers resulting in a derangement of the skeletal muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Flot1tm1.1Arte/Flot1tm1.1Arte,Flot2Gt(258D8)Cmhd/Flot2Gt(258D8)Cmhd,Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Tnnt1tm1.2Jin/Tnnt1tm1.2Jin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009458 abnormal skeletal muscle size "anomaly in the size of the striated muscle fibers connected at either or both extremities with the bony framework of the body" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnnt1tm1.2Jin/Tnnt1tm1.2Jin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000035458 Tnni3 / P48787 / troponin I, cardiac 3 / P19429* / troponin I3, cardiac type*  / complex
 ENSMUSG00000031097 Tnni2 / P13412 / Troponin I, fast skeletal muscle / P48788* / troponin I2, fast skeletal type*  / complex
 ENSMUSG00000017300 Tnnc2 / P20801 / Troponin C, skeletal muscle / P02585* / troponin C2, fast skeletal type*  / complex
 ENSMUSG00000026418 Tnni1 / Q9WUZ5 / Troponin I, slow skeletal muscle / P19237* / troponin I1, slow skeletal type*  / complex
 ENSMUSG00000091898 Tnnc1 / P19123 / Troponin C, slow skeletal and cardiac muscles / P63316* / troponin C1, slow skeletal and cardiac type*  / complex






 

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