ENSMUSG00000067438


Mus musculus

Features
Gene ID: ENSMUSG00000067438
  
Biological name :Hmx1
  
Synonyms : Hmx1 / Homeobox protein HMX1 / O70218
  
Possible biological names infered from orthology : H6 family homeobox 1 / Q9NP08
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: B2
Gene start: 35389108
Gene end: 35399730
  
Corresponding Affymetrix probe sets: 10521385 (MoGene1.0st)   1422152_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000139840
Ensembl peptide - ENSMUSP00000084958
NCBI entrez gene - 15371     See in Manteia.
MGI - MGI:107178
RefSeq - NM_010445
RefSeq - XM_017320684
RefSeq Peptide - NP_034575
swissprot - A0A087WPM8
swissprot - O70218
Ensembl - ENSMUSG00000067438
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hmx1ENSDARG00000095651Danio rerio
 SOHO-1ENSGALG00000015599Gallus gallus
 HMX1ENSG00000215612Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hmx3 / P42581 / Homeobox protein HMX3 / A6NHT5* / H6 family homeobox 3*ENSMUSG0000004014842
Hmx2 / P43687 / Homeobox protein HMX2 / A2RU54* / H6 family homeobox 2*ENSMUSG0000005010030
Nkx3-2 / P97503 / Homeobox protein Nkx-3.2 / P78367* / NK3 homeobox 2*ENSMUSG0000004969124
Nkx3-1 / P97436 / NK3 homeobox 1 / Q99801*ENSMUSG0000002206120
Nkx2-3 / P97334 / Homeobox protein Nkx-2.3 / Q8TAU0* / NK2 homeobox 3*ENSMUSG0000004422019
Nkx2-4 / Q9EQM3 / Homeobox protein Nkx-2.4 / Q9H2Z4* / NK2 homeobox 4*ENSMUSG0000005416019
Nkx2-5 / P42582 / Homeobox protein Nkx-2.5 / P52952* / NK2 homeobox 5*ENSMUSG0000001557918
Nkx2-6 / P43688 / Homeobox protein Nkx-2.6 / A6NCS4* / NK2 homeobox 6*ENSMUSG0000004418618
Nkx2-2 / P42586 / NK2 homeobox 2 / O95096*ENSMUSG0000002743416
Nkx2-9 / O70584 / Homeobox protein Nkx-2.8 / NKX2-8* / O15522* / NK2 homeobox 8*ENSMUSG0000005866916
Nkx2-1 / P50220 / Homeobox protein Nkx-2.1 / P43699* / NK2 homeobox 1*ENSMUSG0000000149615


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IMP
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IMP
 molecular_functionGO:0003677 DNA binding ISO
 molecular_functionGO:0043565 sequence-specific DNA binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000023 abnormal ear distance/ position "anomaly in the space between or the placement of the outer ears " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Hmx1mpe/Hmx1mpe
Genetic Background: C3H/HeJ-Hmx1mpe/J

 MP:0000024 lowered ear position "outer ears which are situated below the normal location " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Hmx1mpe/Hmx1mpe
Genetic Background: C3H/HeJ-Hmx1mpe/J

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
Show

Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002184 abnormal innervation "the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tsc22d3tm1.2Efmd/Y
Genetic Background: Not Specified

 MP:0008383 enlarged gonial bone "increased size of the investing bone that lies on the surface of the malleus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hmx1tm1.1Arte/Hmx1tm1.1Arte,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: BALB/c * C57BL/6J * CBA/J

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Hmx1mpe/Hmx1mpe
Genetic Background: C3H/HeJ-Hmx1mpe/J

 MP:0030119 abnormal retrotympanic process morphology "any structural anomaly of the posterior extension of the squamosal bone that lies just above the incus" [PMID:28566723]
Show

Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0030213 gonial bone hyperplasia "overdevelopment or increased size of the investing bone that lies on the surface of the malleus, usually due to an increased number of cells" [MGI:anna]
Show

Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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