ENSMUSG00000069378


Mus musculus

Features
Gene ID: ENSMUSG00000069378
  
Biological name :Prdm6
  
Synonyms : Prdm6 / Putative histone-lysine N-methyltransferase PRDM6 / Q3UZD5
  
Possible biological names infered from orthology : PR/SET domain 6 / Q9NQX0
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: D1
Gene start: 53464546
Gene end: 53575907
  
Corresponding Affymetrix probe sets: 10455761 (MoGene1.0st)   1436962_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000089513
Ensembl peptide - ENSMUSP00000111056
Ensembl peptide - ENSMUSP00000111057
Ensembl peptide - ENSMUSP00000114644
NCBI entrez gene - 225518     See in Manteia.
MGI - MGI:2684938
RefSeq - XM_017317890
RefSeq - NM_001033281
RefSeq - XM_011246903
RefSeq - XM_011246904
RefSeq - XM_017317889
RefSeq Peptide - NP_001028453
swissprot - Q3UZD5
swissprot - A0A0R4J1Q9
Ensembl - ENSMUSG00000069378
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PRDM6ENSGALG00000005351Gallus gallus
 PRDM6ENSG00000061455Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
E9Q3T6 / Prdm14 / PR domain containing 14 / Q9GZV8* / PR/SET domain 14*ENSMUSG0000004241422
Prdm4 / Q80V63 / PR domain zinc finger protein 4 / Q9UKN5* / PR/SET domain 4*ENSMUSG0000003552917
A2AJ77 / Prdm12 / PR domain zinc finger protein 12 / Q9H4Q4* / PR/SET domain 12*ENSMUSG0000007946617
Rtcb / Q99LF4 / tRNA-splicing ligase RtcB homolog / Q9Y3I0* / RNA 2,3-cyclic phosphate and 5-OH ligase*ENSMUSG000000017838


Protein motifs (from Interpro)
Interpro ID Name
 IPR001214  SET domain
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0022008 neurogenesis IDA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0034968 histone lysine methylation IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0051151 negative regulation of smooth muscle cell differentiation IMP
 cellular_componentGO:0005634 nucleus IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0018024 histone-lysine N-methyltransferase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pdlim7Gt(OST445990)Lex/Pdlim7Gt(OST445990)Lex
Genetic Background: B6.129S5-Pdlim7Gt(OST445990)Lex

 MP:0001182 lung hemorrhage "bleeding in the respiratory organs" [J:66345]
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Allelic Composition: Pdlim7Gt(OST445990)Lex/Pdlim7Gt(OST445990)Lex
Genetic Background: B6.129S5-Pdlim7Gt(OST445990)Lex

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: Pdlim7Gt(OST445990)Lex/Pdlim7Gt(OST445990)Lex
Genetic Background: B6.129S5-Pdlim7Gt(OST445990)Lex

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pdlim7Gt(OST445990)Lex/Pdlim7Gt(OST445990)Lex
Genetic Background: B6.129S5-Pdlim7Gt(OST445990)Lex

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
Show

Allelic Composition: Pdlim7Gt(OST445990)Lex/Pdlim7Gt(OST445990)Lex
Genetic Background: B6.129S5-Pdlim7Gt(OST445990)Lex

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pdlim7Gt(OST445990)Lex/Pdlim7Gt(OST445990)Lex
Genetic Background: B6.129S5-Pdlim7Gt(OST445990)Lex

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Pdlim7Gt(OST445990)Lex/Pdlim7Gt(OST445990)Lex
Genetic Background: B6.129S5-Pdlim7Gt(OST445990)Lex

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Pdlim7Gt(OST445990)Lex/Pdlim7Gt(OST445990)Lex
Genetic Background: B6.129S5-Pdlim7Gt(OST445990)Lex

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Pdlim7Gt(OST445990)Lex/Pdlim7Gt(OST445990)Lex
Genetic Background: B6.129S5-Pdlim7Gt(OST445990)Lex

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Pdlim7Gt(OST445990)Lex/Pdlim7Gt(OST445990)Lex
Genetic Background: B6.129S5-Pdlim7Gt(OST445990)Lex

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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