ENSMUSG00000071113


Mus musculus

Features
Gene ID: ENSMUSG00000071113
  
Biological name :Mboat4
  
Synonyms : Ghrelin O-acyltransferase / Mboat4 / P0C7A3
  
Possible biological names infered from orthology : membrane bound O-acyltransferase domain containing 4 / Q96T53
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: A4
Gene start: 34115030
Gene end: 34125182
  
Corresponding Affymetrix probe sets: 10571300 (MoGene1.0st)   1439752_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000092988
NCBI entrez gene - 234155     See in Manteia.
MGI - MGI:2685017
RefSeq - NM_001126314
RefSeq - XM_006509106
RefSeq Peptide - NP_001119786
swissprot - P0C7A3
Ensembl - ENSMUSG00000071113
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mboat4ENSDARG00000052110Danio rerio
 MBOAT4ENSGALG00000011454Gallus gallus
 MBOAT4ENSG00000177669Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mboat2 / Q8R3I2 / Lysophospholipid acyltransferase 2 / Q6ZWT7* / membrane bound O-acyltransferase domain containing 2*ENSMUSG0000002064621
Mboat1 / Q8BH98 / membrane bound O-acyltransferase domain containing 1 / Q6ZNC8*ENSMUSG0000003873221
Lpcat3 / Q91V01 / Lysophospholipid acyltransferase 5 / Q6P1A2* / lysophosphatidylcholine acyltransferase 3*ENSMUSG0000000427017
Mboat7 / Q8CHK3 / Lysophospholipid acyltransferase 7 / Q96N66* / membrane bound O-acyltransferase domain containing 7*ENSMUSG0000003559617


Protein motifs (from Interpro)
Interpro ID Name
 IPR004299  Membrane bound O-acyl transferase, MBOAT


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0018191 peptidyl-serine octanoylation IDA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030176 integral component of endoplasmic reticulum membrane IDA
 molecular_functionGO:0016412 serine O-acyltransferase activity IDA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA


Pathways (from Reactome)
Pathway description
Synthesis, secretion, and deacylation of Ghrelin


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0004789 increased bile salt level "increased concentration of the steroid salts derived from cholesterol in the liver, produced as bile acids and secreted in the biliary sytem as bile salts; these play an important role in the digestion and absorption of fats" [MESH:D04.808.105, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnfrsf1atm1Mak/Tnfrsf1atm1Mak,Tnip1Gt(E059E05)Wrst/Tnip1Gt(E059E05)Wrst
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0004889 increased energy expenditure "increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkg1tm2.1Naw/Prkg1tm2.1Naw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005120 decreased circulating growth hormone level "less than the expected blood concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pax3tm2.1Joe/Pax3tm2.1Joe
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * BALB/cJ) or (involves: 129S1/Sv * 129X1/SvJ * FVB/N)

 MP:0005186 increased circulating progesterone level "greater than the normal blood concentration of this antiestrogenic steroid" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:66817]
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Allelic Composition: Tnfrsf1atm1Mak/Tnfrsf1atm1Mak,Tnip1Gt(E059E05)Wrst/Tnip1Gt(E059E05)Wrst
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pax3tm2.1Joe/Pax3tm2.1Joe
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * BALB/cJ) or (involves: 129S1/Sv * 129X1/SvJ * FVB/N)

 MP:0005418 abnormal circulating hormone level "anomalous blood concentration of any of the chemical substances that have specific regulatory effects on the activity of a certain organ or organs; originally applied to substances secreted by various endocrine glands and transported in the bloodstream to the target organs, it is sometimes extended to include substances that are not produced by the endocrine glands but that have similar effects" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tnfrsf1atm1Mak/Tnfrsf1atm1Mak,Tnip1Gt(E059E05)Wrst/Tnip1Gt(E059E05)Wrst
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax3tm2.1Joe/Pax3tm2.1Joe
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * BALB/cJ) or (involves: 129S1/Sv * 129X1/SvJ * FVB/N)

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Prkg1tm2.1Naw/Prkg1tm2.1Naw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnfrsf1atm1Mak/Tnfrsf1atm1Mak,Tnip1Gt(E059E05)Wrst/Tnip1Gt(E059E05)Wrst
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax3tm2.1Joe/Pax3tm2.1Joe
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * BALB/cJ) or (involves: 129S1/Sv * 129X1/SvJ * FVB/N)

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkg1tm2.1Naw/Prkg1tm2.1Naw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011611 abnormal circulating ghrelin level "any anomaly in the blood concentration of the peptide hormone produced mainly by P/D1 cells lining the fundus of the stomach and epsilon cells of the pancreas that stimulates hunger and serves as a potent stimulator of growth hormone from the anterior pituitary gland; in addition to stimulating appetite and growth, ghrelin also plays various roles in energy homeostasis, neuropathy, and in the cardiovascular and immune systems" [MGI:anna]
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Allelic Composition: Prkg1tm2.1Naw/Prkg1tm2.1Naw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011613 decreased circulating ghrelin level "less than the normal blood concentration of the peptide hormone produced mainly by P/D1 cells lining the fundus of the stomach and epsilon cells of the pancreas that normally stimulates hunger and serves as a potent stimulator of growth hormone from the anterior pituitary gland" [MGI:anna]
Show

Allelic Composition: Pax3tm2.1Joe/Pax3tm2.1Joe
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * BALB/cJ) or (involves: 129S1/Sv * 129X1/SvJ * FVB/N)

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Prkg1tm2.1Naw/Prkg1tm2.1Naw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000064177 Ghrl / Q9EQX0 / Appetite-regulating hormone Ghrelin Obestatin / Q9UBU3* / ghrelin and obestatin prepropeptide*  / reaction






 

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