ENSMUSG00000072620


Mus musculus

Features
Gene ID: ENSMUSG00000072620
  
Biological name :Slfn2
  
Synonyms : schlafen 2 / Slfn2
  
Possible biological names infered from orthology : Q6IEE8 / Q8IYM2 / schlafen family member 12 / schlafen family member 12 like / SLFN12 / SLFN12L
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: C
Gene start: 83065112
Gene end: 83070678
  
Corresponding Affymetrix probe sets: 10379630 (MoGene1.0st)   1450165_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000035562
NCBI entrez gene - 20556     See in Manteia.
MGI - MGI:1313258
RefSeq - NM_011408
RefSeq Peptide - NP_035538
swissprot - Q9Z0I6
Ensembl - ENSMUSG00000072620
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q6IEE8ENSG00000205045Homo sapiens
 Q8IYM2ENSG00000172123Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Slfn4 / schlafen 4 / Q6IEE8* / Q8IYM2* / SLFN12* / SLFN12L* / schlafen family member 12* / schlafen family member 12 like*ENSMUSG0000000020455
Slfn3 / schlafen 3 / Q6IEE8* / Q8IYM2* / SLFN12* / SLFN12L* / schlafen family member 12* / schlafen family member 12 like*ENSMUSG0000001898650
Slfn1 / schlafen 1 / Q6IEE8* / Q8IYM2* / SLFN12* / SLFN12L* / schlafen family member 12* / schlafen family member 12 like*ENSMUSG0000007876346
Slfn14 / V9GXG1 / Protein SLFN14 C-terminally truncated SLFN14 endoribonuclease / P0C7P3* / schlafen family member 14*ENSMUSG0000008210136
Slfn5 / Q8CBA2 / Schlafen family member 5 / Q08AF3*ENSMUSG0000005440433
Slfn8 / schlafen 8 / SLFN13* / Q68D06* / Q7Z7L1* / SLFN11* / schlafen family member 13* / schlafen family member 11*ENSMUSG0000003520830
Slfn9 / Q7Z7L1* / SLFN11* / SLFN13* / Q68D06* / schlafen family member 11* / schlafen family member 13*ENSMUSG0000006979330


Protein motifs (from Interpro)
Interpro ID Name
 IPR007421  Schlafen, AAA domain
 IPR029684  Schlafen family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008285 negative regulation of cell proliferation IDA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tubb3tm1.1Ece/Tubb3+
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0000223 decreased monocyte count "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tubb3tm1.1Ece/Tubb3+
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Slc26a4m1Btlr/Slc26a4m1Btlr
Genetic Background: C57BL/6J-Slc26a4m1Btlr

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Tubb3tm1.1Ece/Tubb3+
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tubb3tm1.1Ece/Tubb3+
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tubb3tm1.1Ece/Tubb3+
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0002442 abnormal leukocyte physiology "abnormal function of any of the white blood cells (basophils, eosinophils, neutrophils, lymphocytes, or monocytes) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tubb3tm1.1Ece/Tubb3+
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0003957 abnormal nitric oxide homeostasis "anomaly in the state of equilibrium in the body of nitric oxide, a free radical gas and a potent vasodilator" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tubb3tm1.1Ece/Tubb3+
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0005094 abnormal T cell proliferation "anomaly in the clonal expansion of naive T cells" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Tubb3tm1.1Ece/Tubb3+
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Tubb3tm1.1Ece/Tubb3+
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0006413 increased T cell apoptosis "increase in the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tubb3tm1.1Ece/Tubb3+
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tubb3tm1.1Ece/Tubb3+
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tubb3tm1.1Ece/Tubb3+
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tubb3tm1.1Ece/Tubb3+
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0009791 increased susceptibility to viral infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tubb3tm1.1Ece/Tubb3+
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0020001 decreased response to antigen "decreased or weak immune response after exposure to an antigen" [GOC:NV]
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Allelic Composition: Slc26a4m1Btlr/Slc26a4m1Btlr
Genetic Background: C57BL/6J-Slc26a4m1Btlr

 MP:0020154 impaired humoral immune response "impaired response of the immune system that mediates secreted antibodies produced in B cells" [GOC:NV]
Show

Allelic Composition: Slc26a4m1Btlr/Slc26a4m1Btlr
Genetic Background: C57BL/6J-Slc26a4m1Btlr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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