ENSMUSG00000073422


Mus musculus
processH2-Ke6activitydehydrogenasemetabolicreductasefattybiosyntheticshort-chainnadacidestrogenmitochondrialmembranenadhsdrconservedsitep-bindingdomainsuperfamilylipidsteroidandrogenproteinheterotetramerizationoxidation-reductionmitochondrionenvelopematrix

Features
Gene ID: ENSMUSG00000073422
  
Biological name :H2-Ke6
  
Synonyms : H2-Ke6 / H2-K region expressed gene 6 / P50171
  
Possible biological names infered from orthology : HSD17B8 / hydroxysteroid 17-beta dehydrogenase 8 / Q92506
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: B1
Gene start: 34026033
Gene end: 34028060
  
Corresponding Affymetrix probe sets: 10450101 (MoGene1.0st)   10450103 (MoGene1.0st)   1454987_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000038069
Ensembl peptide - ENSMUSP00000133546
NCBI entrez gene - 14979     See in Manteia.
MGI - MGI:95911
RefSeq - NM_013543
RefSeq Peptide - NP_038571
swissprot - G3UX44
swissprot - P50171
Ensembl - ENSMUSG00000073422
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hsd17b8ENSDARG00000001169Danio rerio
 Q92506ENSG00000204228Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cbr4 / Q91VT4 / Carbonyl reductase family member 4 / Q8N4T8* / carbonyl reductase 4*ENSMUSG0000003164133
Hsd17b14 / hydroxysteroid 17-beta dehydrogenase 14 / Q9BPX1*ENSMUSG0000003082531
Dcxr / Q91X52 / L-xylulose reductase / Q7Z4W1* / dicarbonyl and L-xylulose reductase*ENSMUSG0000003945030
Dhrs4 / Q99LB2 / Dehydrogenase/reductase SDR family member 4 / Q6PKH6* / Q9BTZ2* / DHRS4L2* / dehydrogenase/reductase 4* / dehydrogenase/reductase 4 like 2*ENSMUSG0000002221029
Cbr2 / P08074 / Carbonyl reductase [NADPH] 2 ENSMUSG0000002515029
Hsd17b10 / hydroxysteroid 17-beta dehydrogenase 10 / Q99714*ENSMUSG0000002526029
Bdh2 / Q8JZV9 / 3-hydroxybutyrate dehydrogenase type 2 / Q9BUT1* / 3-hydroxybutyrate dehydrogenase 2*ENSMUSG0000002816728
Hpgd / Q8VCC1 / 15-hydroxyprostaglandin dehydrogenase [NAD(+)] / P15428* / 15-hydroxyprostaglandin dehydrogenase*ENSMUSG0000003161328
Dhrs2 / dehydrogenase/reductase 2 / Q13268*ENSMUSG0000002220926


Protein motifs (from Interpro)
Interpro ID Name
 IPR002347  Short-chain dehydrogenase/reductase SDR
 IPR020904  Short-chain dehydrogenase/reductase, conserved site
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
primary metabolic processorganic substance metabolic processcellular metabolic processsmall molecule metabolic processbiosynthetic processregulation of biological qualitycellular component organizationcellular component biogenesisoxidation-reduction processprimary metabolic processorganic substance metabolic processcellular metabolic processsmall molecule metabolic processbiosynthetic processregulation of biological qualitycellular component organizationcellular component biogenesisoxidation-reduction processprimary metabolic processorganic substance metabolic processcellular metabolic processsmall molecule metabolic processbiosynthetic processregulation of biological qualitycellular component organizationcellular component biogenesisoxidation-reduction processprimary metabolic processorganic substance metabolic processcellular metabolic processsmall molecule metabolic processbiosynthetic processregulation of biological qualitycellular component organizationcellular component biogenesisoxidation-reduction processprimary metabolic processorganic substance metabolic processcellular metabolic processsmall molecule metabolic processbiosynthetic processregulation of biological qualitycellular component organizationcellular component biogenesisoxidation-reduction processprimary metabolic processorganic substance metabolic processcellular metabolic processsmall molecule metabolic processbiosynthetic processregulation of biological qualitycellular component organizationcellular component biogenesisoxidation-reduction processprimary metabolic processorganic substance metabolic processcellular metabolic processsmall molecule metabolic processbiosynthetic processregulation of biological qualitycellular component organizationcellular component biogenesisoxidation-reduction processprimary metabolic processorganic substance metabolic processcellular metabolic processsmall molecule metabolic processbiosynthetic processregulation of biological qualitycellular component organizationcellular component biogenesisoxidation-reduction processprimary metabolic processorganic substance metabolic processcellular metabolic processsmall molecule metabolic processbiosynthetic processregulation of biological qualitycellular component organizationcellular component biogenesisoxidation-reduction processprimary metabolic processorganic substance metabolic processcellular metabolic processsmall molecule metabolic processbiosynthetic processregulation of biological qualitycellular component organizationcellular component biogenesisoxidation-reduction processprimary metabolprimary metabolic processorganic substanorganic substance metabolic processcellular metabocellular metabolic processsmall molecule small molecule metabolic processbiosynthetic prbiosynthetic processregulation of bregulation of biological qualitycellular componcellular component organizationcellular componcellular component biogenesisoxidation-reducoxidation-reduction process
oxidoreductase activityion bindingorganic cyclic compound bindingheterocyclic compound bindingcofactor bindingsmall molecule bindingoxidoreductase activityion bindingorganic cyclic compound bindingheterocyclic compound bindingcofactor bindingsmall molecule bindingoxidoreductase activityion bindingorganic cyclic compound bindingheterocyclic compound bindingcofactor bindingsmall molecule bindingoxidoreductase activityion bindingorganic cyclic compound bindingheterocyclic compound bindingcofactor bindingsmall molecule bindingoxidoreductase activityion bindingorganic cyclic compound bindingheterocyclic compound bindingcofactor bindingsmall molecule bindingoxidoreductase activityion bindingorganic cyclic compound bindingheterocyclic compound bindingcofactor bindingsmall molecule bindingoxidoreductase activityion bindingorganic cyclic compound bindingheterocyclic compound bindingcofactor bindingsmall molecule bindingoxidoreductase activityion bindingorganic cyclic compound bindingheterocyclic compound bindingcofactor bindingsmall molecule bindingoxidoreductase activityion bindingorganic cyclic compound bindingheterocyclic compound bindingcofactor bindingsmall molecule bindingoxidoreductase activityion bindingorganic cyclic compound bindingheterocyclic compound bindingcofactor bindingsmall molecule bindingoxidoreductase activityoxidoreductase activityion bindingion bindingorganic cyclic compoundorganic cyclic compound bindingheterocyclic compound bheterocyclic compound bindingcofactor bindingcofactor bindingsmall molecule bindingsmall molecule binding
cellorganellemembrane-enclosed lumenmembranecellorganellemembrane-enclosed lumenmembranecellorganellemembrane-enclosed lumenmembranecellorganellemembrane-enclosed lumenmembranecellorganellemembrane-enclosed lumenmembranecellorganellemembrane-enclosed lumenmembranecellorganellemembrane-enclosed lumenmembranecellorganellemembrane-enclosed lumenmembranecellorganellemembrane-enclosed lumenmembranecellorganellemembrane-enclosed lumenmembranecellcellorganelleorganellemembrane-enclosed lumenmembrane-enclosed lumenmembranemembrane
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006633 fatty acid biosynthetic process ISO
 biological_processGO:0006694 steroid biosynthetic process IEA
 biological_processGO:0006703 estrogen biosynthetic process ISO
 biological_processGO:0008209 androgen metabolic process IDA
 biological_processGO:0008210 estrogen metabolic process IDA
 biological_processGO:0051290 protein heterotetramerization IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005740 mitochondrial envelope IDA
 cellular_componentGO:0005759 mitochondrial matrix ISO
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IDA
 molecular_functionGO:0003857 3-hydroxyacyl-CoA dehydrogenase activity IEA
 molecular_functionGO:0004303 estradiol 17-beta-dehydrogenase activity ISS
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0047025 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity IEA
 molecular_functionGO:0047035 testosterone dehydrogenase (NAD+) activity IDA
 molecular_functionGO:0070404 NADH binding IEA


Pathways (from Reactome)
Pathway description
Fatty acyl-CoA biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031641 Cbr4 / Q91VT4 / Carbonyl reductase family member 4 / Q8N4T8* / carbonyl reductase 4*  / complex
 ENSMUSG00000073422 P50171 / H2-Ke6 / H2-K region expressed gene 6 / Q92506* / HSD17B8* / hydroxysteroid 17-beta dehydrogenase 8*  / complex






 

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