ENSMUSG00000074272


Mus musculus

Features
Gene ID: ENSMUSG00000074272
  
Biological name :Ceacam1
  
Synonyms : Carcinoembryonic antigen-related cell adhesion molecule 1 / Ceacam1 / P31809
  
Possible biological names infered from orthology : AC243967.1 / carcinoembryonic antigen related cell adhesion molecule 3 / carcinoembryonic antigen related cell adhesion molecule 5 / carcinoembryonic antigen related cell adhesion molecule 6 / carcinoembryonic antigen related cell adhesion molecule 7 / carcinoembryonic antigen related cell adhesion molecule 8 / CEACAM3 / CEACAM5 / CEACAM6 / CEACAM7 / CEACAM8 / P06731 / P11464 / P11465 / P13688 / P31997 / P40198 / P40199 / pregnancy specific beta-1-glycoprotein 1 / pregnancy specific beta-1-glycoprotein 11 / pregnancy specific beta-1-glycoprotein 2 / pregnancy specific beta-1-glycoprotein 3 / pregnancy specific beta-1-glycoprotein 4 / pregnancy specific beta-1-glycoprotein 5 / pregnancy specific beta-1-glycoprotein 6 / pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene) / pregnancy specific beta-1-glycoprotein 8 / pregnancy specific beta-1-glycoprotein 9 / PSG1 / PSG11 / PSG2 / PSG3 / PSG4 / PSG5 / PSG6 / PSG7 / PSG8 / PSG9 / Q00887 / Q00888 / Q00889 / Q14002 / Q15238 / Q16557 / Q9UQ72 / Q9UQ74
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: A3
Gene start: 25461707
Gene end: 25477603
  
Corresponding Affymetrix probe sets: 10561008 (MoGene1.0st)   1422123_s_at (Mouse Genome 430 2.0 Array)   1425538_x_at (Mouse Genome 430 2.0 Array)   1425675_s_at (Mouse Genome 430 2.0 Array)   1427630_x_at (Mouse Genome 430 2.0 Array)   1427711_a_at (Mouse Genome 430 2.0 Array)   1427712_at (Mouse Genome 430 2.0 Array)   1450494_x_at (Mouse Genome 430 2.0 Array)   1452532_x_at (Mouse Genome 430 2.0 Array)   1460681_at (Mouse Genome 430 2.0 Array)   1460682_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000096263
Ensembl peptide - ENSMUSP00000096265
Ensembl peptide - ENSMUSP00000146066
Ensembl peptide - ENSMUSP00000146156
Ensembl peptide - ENSMUSP00000096266
Ensembl peptide - ENSMUSP00000145570
Ensembl peptide - ENSMUSP00000145584
Ensembl peptide - ENSMUSP00000145590
NCBI entrez gene - 26365     See in Manteia.
MGI - MGI:1347245
RefSeq - NM_001039187
RefSeq - NM_001039185
RefSeq - NM_001039186
RefSeq - NM_011926
RefSeq Peptide - NP_001034274
RefSeq Peptide - NP_001034275
RefSeq Peptide - NP_001034276
RefSeq Peptide - NP_036056
swissprot - P31809
swissprot - Q3LFS5
swissprot - Q3LFS6
swissprot - Q3LFS7
swissprot - Q3LFS8
swissprot - Q3LFS9
swissprot - Q925P3
Ensembl - ENSMUSG00000074272
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:dkey-250k15.9ENSDARG00000095134Danio rerio
 AC243967.1ENSG00000267881Homo sapiens
 P06731ENSG00000105388Homo sapiens
 P13688ENSG00000079385Homo sapiens
 P31997ENSG00000124469Homo sapiens
 P40198ENSG00000170956Homo sapiens
 P40199ENSG00000086548Homo sapiens
 PSG1ENSG00000231924Homo sapiens
 PSG11ENSG00000243130Homo sapiens
 PSG2ENSG00000242221Homo sapiens
 PSG3ENSG00000221826Homo sapiens
 PSG4ENSG00000243137Homo sapiens
 PSG5ENSG00000204941Homo sapiens
 PSG6ENSG00000170848Homo sapiens
 PSG7ENSG00000221878Homo sapiens
 PSG8ENSG00000124467Homo sapiens
 PSG9ENSG00000183668Homo sapiens
 Q14002ENSG00000007306Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q925P2 / Ceacam2 / Carcinoembryonic antigen-related cell adhesion molecule 2 / PSG4* / PSG5* / PSG6* / PSG7* / PSG8* / PSG9* / PSG2* / PSG1* / PSG3* / PSG11* / Q9UQ74* / Q00888* / Q00887* ...ENSMUSG0000005438582
Ceacam3 / carcinoembryonic antigen-related cell adhesion molecule 3 / PSG3* / PSG4* / PSG5* / PSG6* / PSG7* / PSG8* / PSG9* / PSG2* / PSG1* / PSG11* / Q9UQ74* / P06731* / P11464* / P11465* ...ENSMUSG0000005322828
Psg19 / pregnancy specific glycoprotein 19 / PSG9* / PSG6* / PSG5* / PSG4* / PSG3* / PSG2* / PSG8* / PSG7* / PSG1* / PSG11* / Q9UQ74* / P06731* / P11464* / P11465* / P13688* / P31997* / P40...ENSMUSG0000000454226
Psg22 / Q810J1 / Pregnancy-specific glycoprotein 22 / PSG6* / PSG5* / PSG4* / PSG3* / PSG8* / PSG2* / PSG9* / PSG7* / PSG1* / PSG11* / Q9UQ74* / P06731* / P11464* / P11465* / P13688* / P31...ENSMUSG0000004490326
Q9D2Z1 / Ceacam20 / Carcinoembryonic antigen-related cell adhesion molecule 20 ENSMUSG0000007077726
Psg21 / PSG8* / PSG7* / PSG6* / PSG5* / PSG4* / PSG3* / PSG2* / PSG1* / PSG9* / PSG11* / Q9UQ74* / P06731* / P11464* / P11465* / P13688* / P31997* / P40198* / P40199* / Q00887* / Q00888* / ...ENSMUSG0000007079626
Psg18 / pregnancy specific glycoprotein 18 / PSG9* / PSG6* / PSG5* / PSG4* / PSG3* / PSG2* / PSG8* / PSG7* / PSG1* / PSG11* / Q9UQ74* / P06731* / P11464* / P11465* / P13688* / P31997* / P40...ENSMUSG0000000350525
Psg17 / PSG8* / PSG7* / PSG6* / PSG5* / PSG4* / PSG3* / PSG2* / PSG1* / PSG9* / PSG11* / Q9UQ74* / P06731* / P11464* / P11465* / P13688* / P31997* / P40198* / P40199* / Q00887* / Q00888* / ...ENSMUSG0000000454025
Psg20 / pregnancy-specific glycoprotein 20 / PSG9* / PSG6* / PSG5* / PSG4* / PSG3* / PSG8* / PSG2* / PSG7* / PSG1* / PSG11* / Q9UQ74* / P06731* / P11464* / P11465* / P13688* / P31997* / P4...ENSMUSG0000006330525
Psg26 / pregnancy-specific glycoprotein 26 / PSG9* / PSG6* / PSG5* / PSG4* / PSG3* / PSG8* / PSG2* / PSG7* / PSG1* / PSG11* / Q9UQ74* / P06731* / P11464* / P11465* / P13688* / P31997* / P40...ENSMUSG0000007079925
Psg23 / PSG8* / PSG7* / PSG6* / PSG5* / PSG4* / PSG3* / PSG2* / PSG1* / PSG9* / PSG11* / Q9UQ74* / P06731* / P11464* / P11465* / P13688* / P31997* / P40198* / P40199* / Q00887* / Q00888* / ...ENSMUSG0000007435925
Q3UKK2 / Ceacam5 / Carcinoembryonic antigen-related cell adhesion molecule 5 / PSG7* / PSG6* / PSG5* / PSG1* / PSG4* / PSG3* / PSG2* / PSG9* / PSG8* / PSG11* / Q9UQ74* / P06731* / P11464* ...ENSMUSG0000000878924
Psg28 / PSG8* / PSG7* / PSG6* / PSG5* / PSG4* / PSG3* / PSG2* / PSG1* / PSG9* / PSG11* / Q9UQ74* / P06731* / P11464* / P11465* / P13688* / P31997* / P40198* / P40199* / Q00887* / Q00888* / ...ENSMUSG0000003037324
Psg27 / pregnancy-specific glycoprotein 27 / PSG9* / PSG6* / PSG5* / PSG4* / PSG3* / PSG8* / PSG2* / PSG7* / PSG1* / PSG11* / Q9UQ74* / P06731* / P11464* / P11465* / P13688* / P31997* / P40...ENSMUSG0000007079724
Psg25 / PSG8* / PSG7* / PSG6* / PSG5* / PSG4* / PSG3* / PSG2* / PSG1* / PSG9* / PSG11* / Q9UQ74* / P06731* / P11464* / P11465* / P13688* / P31997* / P40198* / P40199* / Q00887* / Q00888* / ...ENSMUSG0000007079824
E9QA28 / Ceacam16 / Carcinoembryonic antigen-related cell adhesion molecule 16 / Q2WEN9*ENSMUSG0000001468623
Ceacam10 / PSG2* / PSG3* / PSG4* / PSG5* / PSG6* / PSG7* / PSG8* / PSG9* / PSG1* / PSG11* / Q9UQ74* / Q00887* / Q00889* / Q14002* / Q15238* / Q16557* / Q9UQ72* / P06731* / P11464* / P11465*...ENSMUSG0000005416922
Psg29 / PSG8* / PSG7* / PSG6* / PSG5* / PSG4* / PSG3* / PSG2* / PSG1* / PSG9* / PSG11* / Q9UQ74* / P06731* / P11464* / P11465* / P13688* / P31997* / P40198* / P40199* / Q00887* / Q00888* / ...ENSMUSG0000002315921
Psg16 / PSG8* / PSG7* / PSG6* / PSG5* / PSG4* / PSG3* / PSG2* / PSG1* / PSG9* / PSG11* / Q9UQ74* / P06731* / P11464* / P11465* / P13688* / P31997* / P40198* / P40199* / Q00887* / Q00888* / ...ENSMUSG0000006676021
Q9D871 / Ceacam18 / Carcinoembryonic antigen-related cell adhesion molecule 18 / A8MTB9*ENSMUSG0000003047219


Protein motifs (from Interpro)
Interpro ID Name
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001558 regulation of cell growth ISS
 biological_processGO:0001568 blood vessel development IMP
 biological_processGO:0001818 negative regulation of cytokine production IMP
 biological_processGO:0001915 negative regulation of T cell mediated cytotoxicity ISS
 biological_processGO:0002859 negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IMP
 biological_processGO:0006469 negative regulation of protein kinase activity IMP
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IDA
 biological_processGO:0010594 regulation of endothelial cell migration IDA
 biological_processGO:0014066 regulation of phosphatidylinositol 3-kinase signaling ISS
 biological_processGO:0015721 bile acid and bile salt transport ISS
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules IDA
 biological_processGO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IDA
 biological_processGO:0030853 negative regulation of granulocyte differentiation IMP
 biological_processGO:0032692 negative regulation of interleukin-1 production IMP
 biological_processGO:0032703 negative regulation of interleukin-2 production IMP
 biological_processGO:0032869 cellular response to insulin stimulus ISS
 biological_processGO:0035726 common myeloid progenitor cell proliferation IMP
 biological_processGO:0038016 insulin receptor internalization ISS
 biological_processGO:0038158 granulocyte colony-stimulating factor signaling pathway IMP
 biological_processGO:0042058 regulation of epidermal growth factor receptor signaling pathway ISS
 biological_processGO:0042102 positive regulation of T cell proliferation IMP
 biological_processGO:0042130 negative regulation of T cell proliferation IMP
 biological_processGO:0043116 negative regulation of vascular permeability IMP
 biological_processGO:0043318 negative regulation of cytotoxic T cell degranulation ISS
 biological_processGO:0043406 positive regulation of MAP kinase activity ISO
 biological_processGO:0044319 wound healing, spreading of cells ISS
 biological_processGO:0044793 negative regulation by host of viral process IMP
 biological_processGO:0044794 positive regulation by host of viral process IMP
 biological_processGO:0044828 negative regulation by host of viral genome replication IMP
 biological_processGO:0045216 cell-cell junction organization IMP
 biological_processGO:0045601 regulation of endothelial cell differentiation IDA
 biological_processGO:0045671 negative regulation of osteoclast differentiation IMP
 biological_processGO:0045717 negative regulation of fatty acid biosynthetic process ISS
 biological_processGO:0045779 negative regulation of bone resorption IMP
 biological_processGO:0046329 negative regulation of JNK cascade IMP
 biological_processGO:0046330 positive regulation of JNK cascade IDA
 biological_processGO:0046718 viral entry into host cell IDA
 biological_processGO:0048541 Peyer"s patch development IMP
 biological_processGO:0050860 negative regulation of T cell receptor signaling pathway ISS
 biological_processGO:0051024 positive regulation of immunoglobulin secretion IMP
 biological_processGO:0051055 negative regulation of lipid biosynthetic process IMP
 biological_processGO:0060312 regulation of blood vessel remodeling IMP
 biological_processGO:0070237 positive regulation of activation-induced cell death of T cells IMP
 biological_processGO:0070372 regulation of ERK1 and ERK2 cascade ISS
 biological_processGO:0090331 negative regulation of platelet aggregation IMP
 biological_processGO:1901143 insulin catabolic process ISS
 biological_processGO:1903385 regulation of homophilic cell adhesion ISS
 biological_processGO:1903670 regulation of sprouting angiogenesis IMP
 biological_processGO:2000346 negative regulation of hepatocyte proliferation ISS
 biological_processGO:2000516 positive regulation of CD4-positive, alpha-beta T cell activation IMP
 biological_processGO:2000563 positive regulation of CD4-positive, alpha-beta T cell proliferation IMP
 biological_processGO:2001187 positive regulation of CD8-positive, alpha-beta T cell activation IMP
 biological_processGO:2001214 positive regulation of vasculogenesis IMP
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005911 cell-cell junction ISS
 cellular_componentGO:0005912 adherens junction ISS
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0009925 basal plasma membrane ISS
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane ISO
 cellular_componentGO:0016324 apical plasma membrane ISS
 cellular_componentGO:0016328 lateral plasma membrane ISS
 cellular_componentGO:0030054 cell junction ISO
 cellular_componentGO:0030133 transport vesicle IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031526 brush border membrane IDA
 cellular_componentGO:0031528 microvillus membrane IEA
 cellular_componentGO:0042101 T cell receptor complex ISS
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0060170 ciliary membrane IDA
 molecular_functionGO:0001618 virus receptor activity IDA
 molecular_functionGO:0003779 actin binding ISO
 molecular_functionGO:0005130 granulocyte colony-stimulating factor receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding ISS
 molecular_functionGO:0015125 bile acid transmembrane transporter activity ISS
 molecular_functionGO:0019900 kinase binding ISO
 molecular_functionGO:0019903 protein phosphatase binding ISO
 molecular_functionGO:0031005 filamin binding ISO
 molecular_functionGO:0035325 Toll-like receptor binding IPI
 molecular_functionGO:0042803 protein homodimerization activity ISS
 molecular_functionGO:0046790 virion binding IDA
 molecular_functionGO:0046983 protein dimerization activity ISS
 molecular_functionGO:1990782 protein tyrosine kinase binding IPI


Pathways (from Reactome)
Pathway description
Fibronectin matrix formation
Post-translational modification: synthesis of GPI-anchored proteins
Cell surface interactions at the vascular wall
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000495 abnormal colon morphology "malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tbk1tm1Aki/Tbk1tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002410 decreased susceptibility to viral infection "reduced likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tbk1tm1Aki/Tbk1tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ceacam1Hv2-r/Ceacam1Hv2-r
Genetic Background: SJL/J

Allelic Composition: Ceacam1tm1.1Fta/Ceacam1tm1.1Fta
Genetic Background: C57BL/6(FVB)-Ceacam1tm1.1Fta

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Ptf1atm1.1(cre)Cvw/Ptf1atm1.1(cre)Cvw
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * Black Swiss

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tbk1tm1Aki/Tbk1tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004883 abnormal blood vessel healing "anomaly in the repair process of blood vessels after injury" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Mef2atm1.1Limm/Mef2atm1.1Limm,Mef2dtm3Eno/Mef2dtm3Eno,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Ptf1atm1.1(cre)Cvw/Ptf1atm1.1(cre)Cvw
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * Black Swiss

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Ptf1atm1.1(cre)Cvw/Ptf1atm1.1(cre)Cvw
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * Black Swiss

 MP:0008687 increased interleukin-2 secretion "increase in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Ptf1atm1.1(cre)Cvw/Ptf1atm1.1(cre)Cvw
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * Black Swiss

 MP:0009790 decreased susceptibility to viral infection induced morbidity/mortality "reduced likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

Allelic Composition: Ceacam1tm1.1Fta/Ceacam1tm1.1Fta
Genetic Background: C57BL/6(FVB)-Ceacam1tm1.1Fta

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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