MP:0000274 | enlarged heart | "increase over normal size of the heart" [J:29971] |
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Allelic Composition: Slc45a2uw-5J/Slc45a2uw-5J Genetic Background: B6.Cg-Slc45a2uw-5J H2g7 Tg(Ins2-CD80)3B7Flv
Allelic Composition: Xirp1tm1Jl/Xirp1+ Genetic Background: involves: 129
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MP:0000278 | abnormal myocardial fiber morphology | "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048] |
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Allelic Composition: Slc45a2uw-5J/Slc45a2uw-5J Genetic Background: B6.Cg-Slc45a2uw-5J H2g7 Tg(Ins2-CD80)3B7Flv
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MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
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Allelic Composition: Mitfmi-x39/Mitfmi-x39 Genetic Background: involves: 102 * C3H
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MP:0001544 | abnormal cardiovascular system physiology | "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Mitfmi-x39/Mitfmi-x39 Genetic Background: involves: 102 * C3H
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MP:0001625 | cardiac hypertrophy | "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Slc45a2uw-5J/Slc45a2uw-5J Genetic Background: B6.Cg-Slc45a2uw-5J H2g7 Tg(Ins2-CD80)3B7Flv
Allelic Composition: Xirp1tm1Jl/Xirp1+ Genetic Background: involves: 129
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MP:0002127 | abnormal cardiovascular system morphology | "abnormal development of the heart or vascular tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Mitfmi-x39/Mitfmi-x39 Genetic Background: involves: 102 * C3H
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MP:0002972 | abnormal cardiac muscle contractility | "altered ability of the heart muscle to shorten or to develop increased tension, often measured by dP/dT max" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Mitfmi-x39/Mitfmi-x39 Genetic Background: involves: 102 * C3H
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MP:0003141 | cardiac fibrosis | "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Mitfmi-x39/Mitfmi-x39 Genetic Background: involves: 102 * C3H
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MP:0003233 | prolonged QT interval | "increase in the length of time required for ventricular depolarization and repolarization to occur, usually as a result of increased repolarization time" [J:93197, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Slc45a2uw-5J/Slc45a2uw-5J Genetic Background: B6.Cg-Slc45a2uw-5J H2g7 Tg(Ins2-CD80)3B7Flv
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MP:0004067 | abnormal ventricular trabeculae morphology | "aberrant structure of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Slc45a2uw-5J/Slc45a2uw-5J Genetic Background: B6.Cg-Slc45a2uw-5J H2g7 Tg(Ins2-CD80)3B7Flv
Allelic Composition: Xirp1tm1Jl/Xirp1+ Genetic Background: involves: 129
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MP:0004071 | prolonged P wave | "increase in the length of time of the P wave electrical impulses" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Slc45a2uw-5J/Slc45a2uw-5J Genetic Background: B6.Cg-Slc45a2uw-5J H2g7 Tg(Ins2-CD80)3B7Flv
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MP:0004090 | abnormal sarcomere morphology | "any structural abnormality in the segment of a myofibril between two Z lines comprised of multi-protein complexes composed of three different filament systems; these systems work together to contract and relax muscle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Slc45a2uw-5J/Slc45a2uw-5J Genetic Background: B6.Cg-Slc45a2uw-5J H2g7 Tg(Ins2-CD80)3B7Flv
Allelic Composition: Xirp1tm1Dofr/Xirp1tm1Dofr Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0004093 | diffuse Z lines | "widely spread cross-striation bisecting the I band of striated muscle myofibrils and serving as the anchoring point of actin filaments at either end of the sarcomere" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Slc45a2uw-5J/Slc45a2uw-5J Genetic Background: B6.Cg-Slc45a2uw-5J H2g7 Tg(Ins2-CD80)3B7Flv
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MP:0004564 | enlarged myocardial fiber | "increased size of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Slc45a2uw-5J/Slc45a2uw-5J Genetic Background: B6.Cg-Slc45a2uw-5J H2g7 Tg(Ins2-CD80)3B7Flv
Allelic Composition: Xirp1tm1Jl/Xirp1+ Genetic Background: involves: 129
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MP:0005140 | decreased cardiac muscle contractility | "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Mitfmi-x39/Mitfmi-x39 Genetic Background: involves: 102 * C3H
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MP:0005329 | abnormal cardiac muscle morphology | "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Mitfmi-x39/Mitfmi-x39 Genetic Background: involves: 102 * C3H
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MP:0005330 | cardiomyopathy | "diseases of the heart (myocardium); may result from many causes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80681] |
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Allelic Composition: Slc45a2uw-5J/Slc45a2uw-5J Genetic Background: B6.Cg-Slc45a2uw-5J H2g7 Tg(Ins2-CD80)3B7Flv
Allelic Composition: Xirp1tm1Jl/Xirp1+ Genetic Background: involves: 129
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MP:0005608 | cardiac interstitial fibrosis | "formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission] |
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Allelic Composition: Slc45a2uw-5J/Slc45a2uw-5J Genetic Background: B6.Cg-Slc45a2uw-5J H2g7 Tg(Ins2-CD80)3B7Flv
Allelic Composition: Xirp1tm1Jl/Xirp1+ Genetic Background: involves: 129
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MP:0006267 | abnormal intercalated disc morphology | "any structural abnormality in the electron dense junctional complex, at the end to end contacts of cardiac muscle cells, that contains two types of membrane junctions i.e. gap junctions and desmosomes" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:64280] |
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Allelic Composition: Slc45a2uw-5J/Slc45a2uw-5J Genetic Background: B6.Cg-Slc45a2uw-5J H2g7 Tg(Ins2-CD80)3B7Flv
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MP:0010393 | shortened QRS complex duration | "decrease in the length of time of the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarize prior to their contraction; prolongation of the QRS complex duration reflects slowed conduction in the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Xirp1tm1Dofr/Xirp1tm1Dofr Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0010499 | abnormal ventricle myocardium morphology | "any structural anomaly of the ventricular part of middle layer of the heart, comprised of involuntary muscle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Slc45a2uw-5J/Slc45a2uw-5J Genetic Background: B6.Cg-Slc45a2uw-5J H2g7 Tg(Ins2-CD80)3B7Flv
Allelic Composition: Xirp1tm1Jl/Xirp1+ Genetic Background: involves: 129
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MP:0010554 | shortened HV interval | "decrease in the length of time from the initial deflection of the His bundle (H) potential and the onset of ventricular activity" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Xirp1tm1Dofr/Xirp1tm1Dofr Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0020345 | abnormal myocardial fiber currents | "any anomaly in the electrical currents produced by cardiac ion channels, typically measured using whole-cell patch-clamp techniques" [http://www.ncbi.nlm.nih.gov/books/NBK7515/, PMID:21372286, PMID:25368181] |
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Allelic Composition: Slc45a2uw-5J/Slc45a2uw-5J Genetic Background: B6.Cg-Slc45a2uw-5J H2g7 Tg(Ins2-CD80)3B7Flv
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MP:0020346 | abnormal mycardial fiber calcium currents | "any anomaly in the electrical currents produced by cardiac calcium ion channels, typically measured using whole-cell patch-clamp techniques" [ORCID: orcid.org/0000-0003-4606-0597] |
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Allelic Composition: Slc45a2uw-5J/Slc45a2uw-5J Genetic Background: B6.Cg-Slc45a2uw-5J H2g7 Tg(Ins2-CD80)3B7Flv
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MP:0020347 | abnormal mycoardial fiber sodium currents | "any anomaly in the electrical currents produced by cardiac sodium ion channels, typically measured using whole-cell patch-clamp techniques" [ORCID: orcid.org/0000-0003-4606-0597] |
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Allelic Composition: Slc45a2uw-5J/Slc45a2uw-5J Genetic Background: B6.Cg-Slc45a2uw-5J H2g7 Tg(Ins2-CD80)3B7Flv
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MP:0030566 | abnormal A band morphology | "any structural anomaly of the dark-staining region of a sarcomere that is situated between two I bands and marked by partial overlapping of thin (actin) and thick (myosin) filaments; an A band is anisotropic to polarized light and contains the entire length of a single thick filament; its center is traversed by the paler H zone, which in turn contains the M line" [GO:0031672, https://en.wikipedia.org/wiki/Sarcomere, https://medical-dictionary.thefreedictionary.com/A+band] |
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Allelic Composition: Slc45a2uw-5J/Slc45a2uw-5J Genetic Background: B6.Cg-Slc45a2uw-5J H2g7 Tg(Ins2-CD80)3B7Flv
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MP:0030567 | abnormal I band morphology | "any structural anomaly of the light band on each side of the Z disc (aka Z line), comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; the I band is isotropic to polarized light and contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end" [GO:0031674, https://en.wikipedia.org/wiki/Sarcomere] |
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Allelic Composition: Slc45a2uw-5J/Slc45a2uw-5J Genetic Background: B6.Cg-Slc45a2uw-5J H2g7 Tg(Ins2-CD80)3B7Flv
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