ENSMUSG00000079243


Mus musculus

Features
Gene ID: ENSMUSG00000079243
  
Biological name :Xirp1
  
Synonyms : xin actin-binding repeat containing 1 / Xirp1
  
Possible biological names infered from orthology : Q702N8
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: F4
Gene start: 120013755
Gene end: 120023598
  
Corresponding Affymetrix probe sets: 10597764 (MoGene1.0st)   1419220_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000107262
Ensembl peptide - ENSMUSP00000149083
NCBI entrez gene - 22437     See in Manteia.
MGI - MGI:1333878
RefSeq - NM_011724
RefSeq - XM_011242958
RefSeq Peptide - NP_035854
swissprot - E9QQ93
swissprot - A0A1L1SQJ8
Ensembl - ENSMUSG00000079243
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 xirp1ENSDARG00000030722Danio rerio
 XIRP1ENSGALG00000006025Gallus gallus
 XIRP1ENSG00000168334Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Xirp2 / Q4U4S6 / xin actin-binding repeat containing 2 / A4UGR9*ENSMUSG0000002702230


Protein motifs (from Interpro)
Interpro ID Name
 IPR012510  Actin-binding, Xin repeat
 IPR030072  Xin actin-binding repeat-containing protein 1/2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007507 heart development IEA
 biological_processGO:0030036 actin cytoskeleton organization IEA
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0003779 actin binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Slc45a2uw-5J/Slc45a2uw-5J
Genetic Background: B6.Cg-Slc45a2uw-5J H2g7 Tg(Ins2-CD80)3B7Flv

Allelic Composition: Xirp1tm1Jl/Xirp1+
Genetic Background: involves: 129

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
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Allelic Composition: Slc45a2uw-5J/Slc45a2uw-5J
Genetic Background: B6.Cg-Slc45a2uw-5J H2g7 Tg(Ins2-CD80)3B7Flv

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Mitfmi-x39/Mitfmi-x39
Genetic Background: involves: 102 * C3H

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mitfmi-x39/Mitfmi-x39
Genetic Background: involves: 102 * C3H

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Slc45a2uw-5J/Slc45a2uw-5J
Genetic Background: B6.Cg-Slc45a2uw-5J H2g7 Tg(Ins2-CD80)3B7Flv

Allelic Composition: Xirp1tm1Jl/Xirp1+
Genetic Background: involves: 129

 MP:0002127 abnormal cardiovascular system morphology "abnormal development of the heart or vascular tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mitfmi-x39/Mitfmi-x39
Genetic Background: involves: 102 * C3H

 MP:0002972 abnormal cardiac muscle contractility "altered ability of the heart muscle to shorten or to develop increased tension, often measured by dP/dT max" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mitfmi-x39/Mitfmi-x39
Genetic Background: involves: 102 * C3H

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Mitfmi-x39/Mitfmi-x39
Genetic Background: involves: 102 * C3H

 MP:0003233 prolonged QT interval "increase in the length of time required for ventricular depolarization and repolarization to occur, usually as a result of increased repolarization time" [J:93197, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Slc45a2uw-5J/Slc45a2uw-5J
Genetic Background: B6.Cg-Slc45a2uw-5J H2g7 Tg(Ins2-CD80)3B7Flv

 MP:0004067 abnormal ventricular trabeculae morphology "aberrant structure of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Slc45a2uw-5J/Slc45a2uw-5J
Genetic Background: B6.Cg-Slc45a2uw-5J H2g7 Tg(Ins2-CD80)3B7Flv

Allelic Composition: Xirp1tm1Jl/Xirp1+
Genetic Background: involves: 129

 MP:0004071 prolonged P wave "increase in the length of time of the P wave electrical impulses" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Slc45a2uw-5J/Slc45a2uw-5J
Genetic Background: B6.Cg-Slc45a2uw-5J H2g7 Tg(Ins2-CD80)3B7Flv

 MP:0004090 abnormal sarcomere morphology "any structural abnormality in the segment of a myofibril between two Z lines comprised of multi-protein complexes composed of three different filament systems; these systems work together to contract and relax muscle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Slc45a2uw-5J/Slc45a2uw-5J
Genetic Background: B6.Cg-Slc45a2uw-5J H2g7 Tg(Ins2-CD80)3B7Flv

Allelic Composition: Xirp1tm1Dofr/Xirp1tm1Dofr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004093 diffuse Z lines "widely spread cross-striation bisecting the I band of striated muscle myofibrils and serving as the anchoring point of actin filaments at either end of the sarcomere" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Slc45a2uw-5J/Slc45a2uw-5J
Genetic Background: B6.Cg-Slc45a2uw-5J H2g7 Tg(Ins2-CD80)3B7Flv

 MP:0004564 enlarged myocardial fiber "increased size of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc45a2uw-5J/Slc45a2uw-5J
Genetic Background: B6.Cg-Slc45a2uw-5J H2g7 Tg(Ins2-CD80)3B7Flv

Allelic Composition: Xirp1tm1Jl/Xirp1+
Genetic Background: involves: 129

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mitfmi-x39/Mitfmi-x39
Genetic Background: involves: 102 * C3H

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Mitfmi-x39/Mitfmi-x39
Genetic Background: involves: 102 * C3H

 MP:0005330 cardiomyopathy "diseases of the heart (myocardium); may result from many causes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80681]
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Allelic Composition: Slc45a2uw-5J/Slc45a2uw-5J
Genetic Background: B6.Cg-Slc45a2uw-5J H2g7 Tg(Ins2-CD80)3B7Flv

Allelic Composition: Xirp1tm1Jl/Xirp1+
Genetic Background: involves: 129

 MP:0005608 cardiac interstitial fibrosis "formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Slc45a2uw-5J/Slc45a2uw-5J
Genetic Background: B6.Cg-Slc45a2uw-5J H2g7 Tg(Ins2-CD80)3B7Flv

Allelic Composition: Xirp1tm1Jl/Xirp1+
Genetic Background: involves: 129

 MP:0006267 abnormal intercalated disc morphology "any structural abnormality in the electron dense junctional complex, at the end to end contacts of cardiac muscle cells, that contains two types of membrane junctions i.e. gap junctions and desmosomes" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:64280]
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Allelic Composition: Slc45a2uw-5J/Slc45a2uw-5J
Genetic Background: B6.Cg-Slc45a2uw-5J H2g7 Tg(Ins2-CD80)3B7Flv

 MP:0010393 shortened QRS complex duration "decrease in the length of time of the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarize prior to their contraction; prolongation of the QRS complex duration reflects slowed conduction in the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Xirp1tm1Dofr/Xirp1tm1Dofr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010499 abnormal ventricle myocardium morphology "any structural anomaly of the ventricular part of middle layer of the heart, comprised of involuntary muscle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Slc45a2uw-5J/Slc45a2uw-5J
Genetic Background: B6.Cg-Slc45a2uw-5J H2g7 Tg(Ins2-CD80)3B7Flv

Allelic Composition: Xirp1tm1Jl/Xirp1+
Genetic Background: involves: 129

 MP:0010554 shortened HV interval "decrease in the length of time from the initial deflection of the His bundle (H) potential and the onset of ventricular activity" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Xirp1tm1Dofr/Xirp1tm1Dofr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0020345 abnormal myocardial fiber currents "any anomaly in the electrical currents produced by cardiac ion channels, typically measured using whole-cell patch-clamp techniques" [http://www.ncbi.nlm.nih.gov/books/NBK7515/, PMID:21372286, PMID:25368181]
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Allelic Composition: Slc45a2uw-5J/Slc45a2uw-5J
Genetic Background: B6.Cg-Slc45a2uw-5J H2g7 Tg(Ins2-CD80)3B7Flv

 MP:0020346 abnormal mycardial fiber calcium currents "any anomaly in the electrical currents produced by cardiac calcium ion channels, typically measured using whole-cell patch-clamp techniques" [ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Slc45a2uw-5J/Slc45a2uw-5J
Genetic Background: B6.Cg-Slc45a2uw-5J H2g7 Tg(Ins2-CD80)3B7Flv

 MP:0020347 abnormal mycoardial fiber sodium currents "any anomaly in the electrical currents produced by cardiac sodium ion channels, typically measured using whole-cell patch-clamp techniques" [ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Slc45a2uw-5J/Slc45a2uw-5J
Genetic Background: B6.Cg-Slc45a2uw-5J H2g7 Tg(Ins2-CD80)3B7Flv

 MP:0030566 abnormal A band morphology "any structural anomaly of the dark-staining region of a sarcomere that is situated between two I bands and marked by partial overlapping of thin (actin) and thick (myosin) filaments; an A band is anisotropic to polarized light and contains the entire length of a single thick filament; its center is traversed by the paler H zone, which in turn contains the M line" [GO:0031672, https://en.wikipedia.org/wiki/Sarcomere, https://medical-dictionary.thefreedictionary.com/A+band]
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Allelic Composition: Slc45a2uw-5J/Slc45a2uw-5J
Genetic Background: B6.Cg-Slc45a2uw-5J H2g7 Tg(Ins2-CD80)3B7Flv

 MP:0030567 abnormal I band morphology "any structural anomaly of the light band on each side of the Z disc (aka Z line), comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; the I band is isotropic to polarized light and contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end" [GO:0031674, https://en.wikipedia.org/wiki/Sarcomere]
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Allelic Composition: Slc45a2uw-5J/Slc45a2uw-5J
Genetic Background: B6.Cg-Slc45a2uw-5J H2g7 Tg(Ins2-CD80)3B7Flv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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