ENSMUSG00000089960


Mus musculus

Features
Gene ID: ENSMUSG00000089960
  
Biological name :Ugt1a1
  
Synonyms : Q63886 / UDP glucuronosyltransferase 1 family, polypeptide A1 / Ugt1a1
  
Possible biological names infered from orthology : P22309 / UDP glucuronosyltransferase family 1 member A1
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: D
Gene start: 88211959
Gene end: 88218997
  
Corresponding Affymetrix probe sets: 1424783_a_at (Mouse Genome 430 2.0 Array)   1426260_a_at (Mouse Genome 430 2.0 Array)   1426261_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000072803
NCBI entrez gene - 394436     See in Manteia.
MGI - MGI:98898
RefSeq - NM_201645
RefSeq Peptide - NP_964007
swissprot - Q63886
Ensembl - ENSMUSG00000089960
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ugt1a1ENSDARG00000006220Danio rerio
 ugt1b1ENSDARG00000097491Danio rerio
 ugt1b2ENSDARG00000097231Danio rerio
 ugt1b3ENSDARG00000097979Danio rerio
 ugt1b4ENSDARG00000097024Danio rerio
 ugt1b5ENSDARG00000089507Danio rerio
 ugt1b7ENSDARG00000101176Danio rerio
 ENSGALG00000004196Gallus gallus
 P22309ENSG00000241635Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ugt1a5 / UDP glucuronosyltransferase 1 family, polypeptide A5 / P35504* / P35503* / UGT1A3* / UGT1A4* / P22310* / UDP glucuronosyltransferase family 1 member A3* / UDP glucuronosyltransfera...ENSMUSG0000008994369
P70691 / Ugt1a2 / UDP glucuronosyltransferase 1 family, polypeptide A2 / UGT1A5* / P22310* / P35503* / P35504* / UGT1A3* / UGT1A4* / UDP glucuronosyltransferase family 1 member A3* / UDP gl...ENSMUSG0000009017169
Ugt1a8 / UDP glucuronosyltransferase 1 family, polypeptide A8 / Q9HAW9* / Q9HAW8* / UGT1A7* / Q9HAW7* / UGT1A10* / UDP glucuronosyltransferase family 1 member A8* / UDP glucuronosyltransfer...ENSMUSG0000008967566
Ugt1a6b / UDP glucuronosyltransferase 1 family, polypeptide A6B / P19224* / UGT1A6* / UDP glucuronosyltransferase family 1 member A6*ENSMUSG0000009014566
Ugt1a10 / UDP glycosyltransferase 1 family, polypeptide A10 / Q9HAW9* / UGT1A8* / Q9HAW7* / Q9HAW8* / UGT1A7* / UDP glucuronosyltransferase family 1 member A7* / UDP glucuronosyltransferase...ENSMUSG0000009016566
Q62452 / Ugt1a9 / UDP glucuronosyltransferase 1 family, polypeptide A9 / Q9HAW9* / Q9HAW8* / UGT1A7* / UGT1A8* / Q9HAW7* / UGT1A10* / UDP glucuronosyltransferase family 1 member A7* / UDP g...ENSMUSG0000009017566
Q64435 / Ugt1a6a / UDP glucuronosyltransferase 1 family, polypeptide A6A / UGT1A6* / P19224* / UDP glucuronosyltransferase family 1 member A6*ENSMUSG0000005454565
Q6ZQM8 / Q64435 / Ugt1a7c / UDP glucuronosyltransferase 1 family, polypeptide A7C / UGT1A6* / P19224* / UDP glucuronosyltransferase family 1 member A6*ENSMUSG0000009012465
Ugt2b34 / UDP glucuronosyltransferase 2 family, polypeptide B34 / P06133* / P16662* / P36537* / P54855* / Q9BY64* / UGT2B7* / O75310* / O75795* / UGT2B4* / UGT2B11* / UGT2B15* / UGT2B28* / ...ENSMUSG0000002926044
Q80X89 / Ugt2a1 / UDP glucuronosyltransferase 2 family, polypeptide A1 / Q9Y4X1* / UDP glucuronosyltransferase family 2 member A1 complex locus*ENSMUSG0000010667743
Ugt2a1 / Q6PDD0 / Ugt2a2 / UDP glucuronosyltransferase 2 family, polypeptide A2 / Q9Y4X1* / UDP glucuronosyltransferase family 2 member A2*ENSMUSG0000002926842
Ugt2b1 / UDP glucuronosyltransferase 2 family, polypeptide B1 / P06133* / P16662* / P36537* / P54855* / Q9BY64* / UGT2B7* / O75310* / O75795* / UGT2B4* / UGT2B10* / UGT2B11* / UGT2B28* / UG...ENSMUSG0000003583642
Ugt2b36 / UDP glucuronosyltransferase 2 family, polypeptide B36 / P06133* / P16662* / P36537* / P54855* / Q9BY64* / UGT2B7* / O75310* / O75795* / UGT2B4* / UGT2B11* / UGT2B15* / UGT2B28* / ...ENSMUSG0000007070442
Q8BWQ1 / Ugt2a3 / UDP glucuronosyltransferase 2 family, polypeptide A3 / Q6UWM9* / UDP glucuronosyltransferase family 2 member A3*ENSMUSG0000003578040
Ugt2b35 / UDP glucuronosyltransferase 2 family, polypeptide B35 / P06133* / P16662* / P36537* / P54855* / Q9BY64* / UGT2B7* / O75310* / O75795* / UGT2B4* / UGT2B11* / UGT2B15* / UGT2B28* / ...ENSMUSG0000003581140
Ugt2b37 / UDP glucuronosyltransferase 2 family, polypeptide B37 / P06133* / P16662* / P36537* / P54855* / Q9BY64* / UGT2B7* / O75310* / O75795* / UGT2B4* / UGT2B11* / UGT2B15* / UGT2B28* / ...ENSMUSG0000005742540
Ugt2b5 / UDP glucuronosyltransferase 2 family, polypeptide B5 / P06133* / P16662* / P36537* / P54855* / Q9BY64* / UGT2B7* / O75310* / O75795* / UGT2B4* / UGT2B11* / UGT2B15* / UGT2B28* / UG...ENSMUSG0000005463039
Ugt2b38 / UDP glucuronosyltransferase 2 family, polypeptide B38 / P06133* / P16662* / P36537* / P54855* / Q9BY64* / UGT2B7* / O75310* / O75795* / UGT2B4* / UGT2B11* / UGT2B15* / UGT2B28* / ...ENSMUSG0000006190639
Gm43638 / Q9Y4X1* / UGT2A1* / UDP glucuronosyltransferase family 2 member A1 complex locus*ENSMUSG0000010718038
Ugt8a / Q64676 / UDP galactosyltransferase 8A / UGT8* / Q16880* / UDP glycosyltransferase 8*ENSMUSG0000003285431


Protein motifs (from Interpro)
Interpro ID Name
 IPR002213  UDP-glucuronosyl/UDP-glucosyltransferase
 IPR035595  UDP-glycosyltransferase family, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001889 liver development IEA
 biological_processGO:0006953 acute-phase response IEA
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0031100 animal organ regeneration IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032870 cellular response to hormone stimulus IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042594 response to starvation IEA
 biological_processGO:0043086 negative regulation of catalytic activity IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0048545 response to steroid hormone IEA
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0051552 flavone metabolic process IEA
 biological_processGO:0052695 cellular glucuronidation IEA
 biological_processGO:0052696 flavonoid glucuronidation IEA
 biological_processGO:0052697 xenobiotic glucuronidation IEA
 biological_processGO:0070980 biphenyl catabolic process IEA
 biological_processGO:0071361 cellular response to ethanol IEA
 biological_processGO:0071385 cellular response to glucocorticoid stimulus IEA
 biological_processGO:0071392 cellular response to estradiol stimulus IEA
 biological_processGO:0071466 cellular response to xenobiotic stimulus IEA
 biological_processGO:2001030 negative regulation of cellular glucuronidation ISO
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0034663 endoplasmic reticulum chaperone complex IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0070069 cytochrome complex IEA
 molecular_functionGO:0001972 retinoic acid binding IEA
 molecular_functionGO:0004857 enzyme inhibitor activity IEA
 molecular_functionGO:0005496 steroid binding IEA
 molecular_functionGO:0015020 glucuronosyltransferase activity ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA
 molecular_functionGO:0016758 transferase activity, transferring hexosyl groups IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Glucuronidation
Heme degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000089960 Q63886 / Ugt1a1 / UDP glucuronosyltransferase 1 family, polypeptide A1 / P22309* / UDP glucuronosyltransferase family 1 member A1*  / complex






 

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