ENSMUSG00000090019


Mus musculus

Features
Gene ID: ENSMUSG00000090019
  
Biological name :Gimap1
  
Synonyms : Gimap1 / GTPase, IMAP family member 1
  
Possible biological names infered from orthology : Q8WWP7
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: B2.3
Gene start: 48739054
Gene end: 48743795
  
Corresponding Affymetrix probe sets: 10538138 (MoGene1.0st)   1449988_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000145479
Ensembl peptide - ENSMUSP00000062108
Ensembl peptide - ENSMUSP00000118345
NCBI entrez gene - 16205     See in Manteia.
MGI - MGI:109368
RefSeq - NM_008376
RefSeq - NM_175860
RefSeq Peptide - NP_032402
RefSeq Peptide - NP_787056
swissprot - D3YX11
swissprot - Q3TFI6
Ensembl - ENSMUSG00000090019
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 AL953865.1ENSDARG00000109438Danio rerio
 BX004816.1ENSDARG00000040497Danio rerio
 BX569789.1ENSDARG00000099678Danio rerio
 CABZ01049362.1ENSDARG00000099508Danio rerio
 CABZ01059407.1ENSDARG00000115164Danio rerio
 CABZ01059408.1ENSDARG00000116928Danio rerio
 CR388047.1ENSDARG00000090015Danio rerio
 CR774195.1ENSDARG00000078832Danio rerio
 FO680692.1ENSDARG00000109228Danio rerio
 FP326649.2ENSDARG00000117179Danio rerio
 LO018551.1ENSDARG00000115941Danio rerio
 LO018605.1ENSDARG00000093082Danio rerio
 si:ch1073-185p12.2ENSDARG00000100199Danio rerio
 si:ch1073-322p19.1ENSDARG00000075173Danio rerio
 si:ch211-113e8.5ENSDARG00000069707Danio rerio
 si:ch211-113e8.6ENSDARG00000074610Danio rerio
 si:ch211-229i14.2ENSDARG00000086048Danio rerio
 si:ch73-285p12.4ENSDARG00000054548Danio rerio
 si:ch73-308m11.1ENSDARG00000039752Danio rerio
 si:dkey-125e8.4ENSDARG00000041333Danio rerio
 si:dkey-1c7.3ENSDARG00000074205Danio rerio
 si:dkey-73p2.1ENSDARG00000095739Danio rerio
 si:dkey-73p2.2ENSDARG00000079245Danio rerio
 si:dkey-73p2.3ENSDARG00000095076Danio rerio
 si:dkey-88j15.3ENSDARG00000076573Danio rerio
 si:dkey-88j15.4ENSDARG00000079471Danio rerio
 si:dkeyp-52c3.5ENSDARG00000038392Danio rerio
 si:dkeyp-67a8.4ENSDARG00000090099Danio rerio
 si:dkeyp-67a8.4ENSDARG00000092823Danio rerio
 zgc:113625ENSDARG00000054160Danio rerio
 zgc:152658ENSDARG00000018587Danio rerio
 zgc:153642ENSDARG00000052900Danio rerio
 zgc:171452ENSDARG00000074069Danio rerio
 zgc:172091ENSDARG00000103058Danio rerio
 zgc:194443ENSDARG00000078182Danio rerio
 GIMAP1ENSG00000213203Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gimap5 / Q8BWF2 / GTPase IMAP family member 5 / Q96F15* / GIMAP1-GIMAP5* / GIMAP1-GIMAP5 readthrough*ENSMUSG0000004350536
Q99MI6 / Gimap3 / GTPase IMAP family member 3 / GIMAP5* / Q96F15* / GIMAP1-GIMAP5* / GIMAP1-GIMAP5 readthrough* / GTPase, IMAP family member 5*ENSMUSG0000003926435
Gimap7 / Q8NHV1* / GTPase, IMAP family member 7*ENSMUSG0000004393132
Gimap6 / Q8K349 / GTPase IMAP family member 6 / Q6P9H5*ENSMUSG0000004786730
Gimap4 / Q99JY3 / GTPase IMAP family member 4 / Q9NUV9*ENSMUSG0000005443530
Gimap9 / GIMAP7* / Q8NHV1* / GTPase, IMAP family member 7*ENSMUSG0000005112428
Gimap8 / Q75N62 / GTPase IMAP family member 8 / Q8ND71*ENSMUSG0000006426228


Protein motifs (from Interpro)
Interpro ID Name
 IPR006703  AIG1-type guanine nucleotide-binding (G) domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005525 GTP binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Fgfr3tm6.2Cxd/Fgfr3tm6.2Cxd
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0004392 abnormal CD8-positive T cell physiology "abnormal function of the subset of T lymphocytes that express the CD8 marker on the cell surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr3tm6.2Cxd/Fgfr3tm6.2Cxd
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fgfr3tm6.2Cxd/Fgfr3tm6.2Cxd
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fgfr3tm6.2Cxd/Fgfr3tm6.2Cxd
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fgfr3tm6.2Cxd/Fgfr3tm6.2Cxd
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fgfr3tm6.2Cxd/Fgfr3tm6.2Cxd
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr3tm6.2Cxd/Fgfr3tm6.2Cxd
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr3tm6.2Cxd/Fgfr3tm6.2Cxd
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0008168 decreased B-1a cell number "reduced number of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604]
Show

Allelic Composition: Fgfr3tm6.2Cxd/Fgfr3tm6.2Cxd
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0008170 decreased B-1b cell number "reduced number of the B-1 B cell subset not bearing the CD5 surface marker, but having other phenotypic attributes of a B-1 B cell" [CL:0000821, PMID:11861604]
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Allelic Composition: Fgfr3tm6.2Cxd/Fgfr3tm6.2Cxd
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0008174 decreased follicular B cell number "reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr3tm6.2Cxd/Fgfr3tm6.2Cxd
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0008182 decreased marginal zone B cell number "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
Show

Allelic Composition: Fgfr3tm6.2Cxd/Fgfr3tm6.2Cxd
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0008207 decreased B-2 cell number "reduced number of conventional B cells subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells" [CL:0000822, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:11861604]
Show

Allelic Composition: Fgfr3tm6.2Cxd/Fgfr3tm6.2Cxd
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0009926 decreased transitional stage T2 B cell number "reduced number of a type of transitional stage B cell that has the phenotype surface IgM-positive, surface IgD-postive, CD21-positive, CD23-positive, CD62L-negative, and is located in the splenic B follicles" [PMID:12810111]
Show

Allelic Composition: Fgfr3tm6.2Cxd/Fgfr3tm6.2Cxd
Genetic Background: involves: 129S6/SvEvTac * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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