ENSMUSG00000095079


Mus musculus

Features
Gene ID: ENSMUSG00000095079
  
Biological name :Igha
  
Synonyms : Igha
  
Possible biological names infered from orthology : IGHA1 / IGHA2 / immunoglobulin heavy constant alpha 1 / immunoglobulin heavy constant alpha 2 (A2m marker) / P01876 / P01877
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: F1
Gene start: 113254830
Gene end: 113260236
  
Corresponding Affymetrix probe sets: 1421653_a_at (Mouse Genome 430 2.0 Array)   1425763_x_at (Mouse Genome 430 2.0 Array)   1429381_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000137226
Ensembl peptide - ENSMUSP00000142171
MGI - MGI:96444
swissprot - A0A075B6A3
swissprot - A0A0A6YXW6
Ensembl - ENSMUSG00000095079
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ighv1-4ENSDARG00000096355Danio rerio
 IGHA1ENSG00000211895Homo sapiens
 IGHA2ENSG00000211890Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ighm / immunoglobulin heavy constant mu / P01871*ENSMUSG0000007661731
Ighg2b / IGHG1* / IGHG2* / IGHG3* / IGHG4* / P01861* / P01857* / P01859* / immunoglobulin heavy constant gamma 4 (G4m marker)* / immunoglobulin heavy constant gamma 1 (G1m marker)* / immuno...ENSMUSG0000007661329
Ighe / P01854* / immunoglobulin heavy constant epsilon*ENSMUSG0000008764227
Ighg2c / IGHG1* / IGHG2* / IGHG3* / IGHG4* / P01861* / P01857* / P01859* / immunoglobulin heavy constant gamma 4 (G4m marker)* / immunoglobulin heavy constant gamma 1 (G1m marker)* / immuno...ENSMUSG0000007661226
Ighg1 / IGHG2* / IGHG3* / IGHG4* / P01861* / P01857* / P01859* / immunoglobulin heavy constant gamma 4 (G4m marker)* / immunoglobulin heavy constant gamma 1 (G1m marker)* / immunoglobulin h...ENSMUSG0000007661426
Ighg3 / IGHG1* / IGHG2* / IGHG4* / P01861* / P01857* / P01859* / immunoglobulin heavy constant gamma 4 (G4m marker)* / immunoglobulin heavy constant gamma 1 (G1m marker)* / immunoglobulin h...ENSMUSG0000007661526


Protein motifs (from Interpro)
Interpro ID Name
No match


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002385 mucosal immune response IDA
 biological_processGO:0002455 humoral immune response mediated by circulating immunoglobulin IDA
 biological_processGO:0006910 phagocytosis, recognition IBA
 biological_processGO:0006911 phagocytosis, engulfment IBA
 biological_processGO:0006958 complement activation, classical pathway IBA
 biological_processGO:0016064 immunoglobulin mediated immune response IDA
 biological_processGO:0042742 defense response to bacterium IBA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0050853 B cell receptor signaling pathway IBA
 biological_processGO:0050871 positive regulation of B cell activation IBA
 cellular_componentGO:0009897 external side of plasma membrane IBA
 cellular_componentGO:0042571 immunoglobulin complex, circulating IDA
 cellular_componentGO:0072562 blood microparticle IBA
 molecular_functionGO:0003823 antigen binding IDA
 molecular_functionGO:0034987 immunoglobulin receptor binding IBA


Pathways (from Reactome)
Pathway description
Cell surface interactions at the vascular wall
Scavenging of heme from plasma


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atf2tm1Glm/Atf2tm1Glm
Genetic Background: C.Cg-Atf2tm1Glm

Allelic Composition: Ighatm1(Myc)Janz/Igha+,Tg(Tnfsf13b)1Fma/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2J

 MP:0001807 decreased IgA "less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bmp4tm1Blh/Bmp4+,Bmp8btm1Blh/Bmp8b+
Genetic Background: involves: 129/Sv * 129S2/SvPas * Black Swiss

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Bmp4tm1Blh/Bmp4+,Bmp8btm1Blh/Bmp8b+
Genetic Background: involves: 129/Sv * 129S2/SvPas * Black Swiss

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh,Serping1Gt1Aed/Serping1Gt1Aed
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0002026 leukemia "progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
Show

Allelic Composition: Atf2tm1Glm/Atf2tm1Glm
Genetic Background: C.Cg-Atf2tm1Glm

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atf2tm1Glm/Atf2tm1Glm
Genetic Background: C.Cg-Atf2tm1Glm

Allelic Composition: Ighatm1(Myc)Janz/Igha+,Tg(Tnfsf13b)1Fma/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2J

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
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Allelic Composition: Ighatm1Grh/Ighatm1Grh
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bmp4tm1Blh/Bmp4+,Bmp8btm1Blh/Bmp8b+
Genetic Background: involves: 129/Sv * 129S2/SvPas * Black Swiss

 MP:0002439 abnormal plasma cell morphology/development "anomalous structure, differentiation, or number of the specialized forms of B-lympocytes which produce and secrete immunoglobulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atf2tm1Glm/Atf2tm1Glm
Genetic Background: C.Cg-Atf2tm1Glm

 MP:0002490 abnormal circulating immunoglobulin concentration "deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Bmp4tm1Blh/Bmp4+,Bmp8btm1Blh/Bmp8b+
Genetic Background: involves: 129/Sv * 129S2/SvPas * Black Swiss

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bmp4tm1Blh/Bmp4+,Bmp8btm1Blh/Bmp8b+
Genetic Background: involves: 129/Sv * 129S2/SvPas * Black Swiss

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Atf2tm1Glm/Atf2tm1Glm
Genetic Background: C.Cg-Atf2tm1Glm

Allelic Composition: Ighatm1Grh/Ighatm1Grh
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Atf2tm1Glm/Atf2tm1Glm
Genetic Background: C.Cg-Atf2tm1Glm

Allelic Composition: Ighatm1Grh/Ighatm1Grh
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vcam1tm2Flv/Vcam1tm2Flv,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ighatm1(Myc)Janz/Igha+,Tg(Tnfsf13b)1Fma/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2J

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ighatm1(Myc)Janz/Igha+,Tg(Tnfsf13b)1Fma/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2J

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rb1tm1Brd/Rb1+,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Ighatm1Grh/Ighatm1Grh
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005154 increased B cell proliferation "greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh,Serping1Gt1Aed/Serping1Gt1Aed
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0008051 abnormal memory T cell physiology "any functional anomaly of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Ighatm1Grh/Ighatm1Grh
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008097 increased plasma cell number "greater number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh,Serping1Gt1Aed/Serping1Gt1Aed
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Ighatm1(Myc)Janz/Igha+,Tg(Igk-V21-Bax)1967Bvn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N

 MP:0008210 increased mature B cell number "greater number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
Show

Allelic Composition: Ighatm1(Myc)Janz/Igha+,Tg(Tnfsf13b)1Fma/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2J

 MP:0008478 increased spleen white pulp amount "increase in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ighatm1(Myc)Janz/Igha+,Tg(Tnfsf13b)1Fma/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2J

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ighatm1Grh/Ighatm1Grh
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Ighatm1Grh/Ighatm1Grh
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ighatm1Grh/Ighatm1Grh
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008501 increased IgG2b level "greater than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Ighatm1Grh/Ighatm1Grh
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Ighatm1Grh/Ighatm1Grh
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Ighatm1Grh/Ighatm1Grh
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008699 increased interleukin-4 secretion "increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Ighatm1Grh/Ighatm1Grh
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008781 abnormal B cell apoptosis "change in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ighatm1(Myc)Janz/Igha+,Tg(Igk-V21-Bax)1967Bvn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N

 MP:0008782 increased B cell apoptosis "increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh,Serping1Gt1Aed/Serping1Gt1Aed
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0010286 increased plasmacytoma incidence "greater than the expected number of neoplastic plasma cells in bone or in one of the extramedullary sites occurring in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ighatm1(Myc)Janz/Igha+,Tg(Igk-V21-Bax)1967Bvn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N

 MP:0010337 increased chronic lymphocytic leukemia incidence 
Show

Allelic Composition: Ighatm1(Myc)Janz/Igha+,Tg(Tnfsf13b)1Fma/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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