ENSMUSG00000101252


Mus musculus

Features
Gene ID: ENSMUSG00000101252
  
Biological name :Ifna6
  
Synonyms : Ifna6
  
Possible biological names infered from orthology : IFNA1 / IFNA10 / IFNA13 / IFNA14 / IFNA16 / IFNA17 / IFNA2 / IFNA21 / IFNA4 / IFNA5 / IFNA7 / IFNA8 / interferon alpha 1 / interferon alpha 10 / interferon alpha 13 / interferon alpha 14 / interferon alpha 16 / interferon alpha 17 / interferon alpha 2 / interferon alpha 21 / interferon alpha 4 / interferon alpha 5 / interferon alpha 6 / interferon alpha 7 / interferon alpha 8 / P01562 / P01563 / P01566 / P01567 / P01568 / P01569 / P01570 / P01571 / P05013 / P05014 / P05015 / P32881
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: C4
Gene start: 88827416
Gene end: 88827985
  
Corresponding Affymetrix probe sets: 10505884 (MoGene1.0st)   10514289 (MoGene1.0st)   1450593_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000100777
NCBI entrez gene - 15969     See in Manteia.
MGI - MGI:107662
RefSeq - NM_206871
RefSeq Peptide - NP_996754
swissprot - Q810G5
Ensembl - ENSMUSG00000101252
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000015062Gallus gallus
 IFNA1ENSG00000197919Homo sapiens
 IFNA10ENSG00000186803Homo sapiens
 IFNA13ENSG00000233816Homo sapiens
 IFNA14ENSG00000228083Homo sapiens
 IFNA16ENSG00000147885Homo sapiens
 IFNA17ENSG00000234829Homo sapiens
 IFNA2ENSG00000188379Homo sapiens
 IFNA21ENSG00000137080Homo sapiens
 IFNA4ENSG00000236637Homo sapiens
 IFNA5ENSG00000147873Homo sapiens
 IFNA6ENSG00000120235Homo sapiens
 IFNA7ENSG00000214042Homo sapiens
 IFNA8ENSG00000120242Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ifnab / IFNA6* / IFNA7* / IFNA8* / IFNA2* / IFNA4* / IFNA1* / IFNA5* / P32881* / IFNA10* / IFNA13* / IFNA14* / IFNA16* / IFNA17* / IFNA21* / P01562* / P01563* / P01566* / P01567* / P01568* ...ENSMUSG0000010007992
Ifna15 / IFNA5* / IFNA6* / IFNA7* / IFNA8* / IFNA1* / IFNA2* / IFNA4* / P32881* / IFNA10* / IFNA13* / IFNA14* / IFNA16* / IFNA17* / IFNA21* / P01562* / P01563* / P01566* / P01567* / P01568*...ENSMUSG0000009601190
Ifna5 / IFNA6* / IFNA7* / IFNA8* / IFNA1* / IFNA2* / IFNA4* / P32881* / IFNA10* / IFNA13* / IFNA14* / IFNA16* / IFNA17* / IFNA21* / P01562* / P01563* / P01566* / P01567* / P01568* / P01569*...ENSMUSG0000009668290
Q80SU4 / Ifna13 / Interferon alpha-13 / IFNA7* / IFNA8* / IFNA1* / IFNA2* / IFNA4* / IFNA6* / IFNA5* / IFNA10* / IFNA14* / IFNA16* / IFNA17* / IFNA21* / P01562* / P01563* / P01566* / P0156...ENSMUSG0000006337689
Ifna12 / Q80SS5 / Interferon alpha-12 / IFNA2* / IFNA1* / IFNA5* / IFNA4* / IFNA6* / IFNA7* / IFNA8* / P01571* / IFNA10* / IFNA13* / IFNA14* / IFNA16* / IFNA17* / IFNA21* / P01562* / P0156...ENSMUSG0000007381189
Ifna1 / P01572 / Interferon alpha-1 / IFNA2* / IFNA5* / IFNA4* / IFNA6* / IFNA7* / IFNA8* / P32881* / IFNA10* / IFNA13* / IFNA14* / IFNA16* / IFNA17* / IFNA21* / P01562* / P01563* / P01566...ENSMUSG0000009549888
Ifna9 / P09235 / Interferon alpha-9 / IFNA1* / IFNA4* / IFNA6* / IFNA5* / IFNA7* / IFNA8* / IFNA2* / P32881* / IFNA10* / IFNA13* / IFNA14* / IFNA16* / IFNA17* / IFNA21* / P01562* / P01563*...ENSMUSG0000009527087
Ifna7 / IFNA5* / IFNA6* / IFNA8* / IFNA1* / IFNA2* / IFNA4* / P32881* / IFNA10* / IFNA13* / IFNA14* / IFNA16* / IFNA17* / IFNA21* / P01562* / P01563* / P01566* / P01567* / P01568* / P01569*...ENSMUSG0000010071387
Ifna14 / IFNA6* / IFNA7* / IFNA8* / IFNA2* / IFNA4* / IFNA1* / IFNA5* / P32881* / IFNA10* / IFNA13* / IFNA16* / IFNA17* / IFNA21* / P01562* / P01563* / P01566* / P01567* / P01568* / P01569*...ENSMUSG0000009589685
Ifna11 / Q61716 / Interferon alpha-11 / IFNA2* / IFNA1* / IFNA5* / IFNA4* / IFNA6* / IFNA7* / IFNA8* / P01571* / IFNA10* / IFNA13* / IFNA14* / IFNA16* / IFNA17* / IFNA21* / P01562* / P0156...ENSMUSG0000010054985
Ifna2 / interferon alpha 2 / IFNA7* / IFNA8* / IFNA4* / IFNA1* / IFNA5* / IFNA6* / P32881* / IFNA10* / IFNA13* / IFNA14* / IFNA16* / IFNA17* / IFNA21* / P01562* / P01563* / P01566* / P01567...ENSMUSG0000007835483
Ifna4 / P07351 / Interferon alpha-4 / IFNA7* / IFNA5* / IFNA8* / IFNA2* / IFNA1* / IFNA6* / P32881* / IFNA10* / IFNA13* / IFNA14* / IFNA16* / IFNA17* / IFNA21* / P01562* / P01563* / P01566...ENSMUSG0000007090482
Ifna16 / IFNA6* / IFNA7* / IFNA4* / IFNA1* / IFNA2* / IFNA8* / IFNA5* / P32881* / IFNA10* / IFNA13* / IFNA14* / IFNA17* / IFNA21* / P01562* / P01563* / P01566* / P01567* / P01568* / P01569*...ENSMUSG0000007835582
Ifnk / Q7TSL0 / Interferon kappa / Q9P0W0*ENSMUSG0000004299326


Protein motifs (from Interpro)
Interpro ID Name
 IPR000471  Interferon alpha/beta/delta
 IPR009079  Four-helical cytokine-like, core


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006952 defense response IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0051607 defense response to virus IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005126 cytokine receptor binding IEA


Pathways (from Reactome)
Pathway description
Interferon alpha/beta signaling
Regulation of IFNA signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cadps2tm1Bros/Cadps2tm1Bros
Genetic Background: Not Specified

 MP:0002446 abnormal macrophage morphology "anomalous structure, number, or composition of the large mononuclear phagocytic cells found in most tissues of the body" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ifna6tm1Aki/Ifna6+,Myd88tm1Aki/Myd88tm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0004242 abnormal plasmacytoid dendritic cell morphology "any structural anomaly of phagocytic dendritic cells that are morphologically similar to plasma cells, but do not express B lineage markers, and produce large amounts of alpha/beta interferons (IFN-/) in response to viral and bacterial stimuli; plasmacytoid dendritic cells are found in the thymic medulla and lymph node T cell areas and are responsible for immune tolerance" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:10449155, PMID:15596797]
Show

Allelic Composition: Cadps2tm1Bros/Cadps2tm1Bros
Genetic Background: Not Specified

 MP:0006173 abnormal Langerhans cell morphology/development "anomaly in the formation or structure of phagocytic dendritic cells principally found in the epidemis and mucosal epithelium" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95147]
Show

Allelic Composition: Ifna6tm1Aki/Ifna6+,Myd88tm1Aki/Myd88tm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0008245 abnormal alveolar macrophage morphology "any structural anomaly of the round, granular, mononuclear phagocytes found in the alveoli of the lungs which ingest small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells" [CL:0000583, MESH:A.11.329.372.600]
Show

Allelic Composition: Ifna6tm1Aki/Ifna6+,Myd88tm1Aki/Myd88tm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0008563 decreased interferon-alpha secretion "increase in the production or release of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells" [MESH:D12.644.276.374.440.890.250]
Show

Allelic Composition: Cadps2tm1Bros/Cadps2tm1Bros
Genetic Background: Not Specified

Allelic Composition: Mavstm1Aki/Mavstm1Aki,Ifna6tm1Aki/Ifna6+
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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