2067


Homo sapiens (NCBI)
repairdnabindingresponsecomplexformationincisionregulationfactorsingle-strandedproteincellaging-tolesionendjoiningrecombinationstressdevelopmentprotectionmulticellularorganismtelomeretelomerict-circletranscriptionendodeoxyribonucleaseactivity

Features
Gene ID: 2067
  
Biological name :
  
Synonyms : COFS4|RAD10|UV20 / ERCC1 / ERCC excision repair 1, endonuclease non-catalytic subunit
  
Possible biological names infered from orthology :
  
Species: Homo sapiens (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 203719_at (Human Genome U133 Plus 2.0 Array)   203720_s_at (Human Genome U133 Plus 2.0 Array)   228131_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: RefSeq - 530415962
RefSeq - 1034606738
RefSeq - 1034606740
RefSeq - 1034606742
RefSeq - 1034606744
RefSeq - 1034606746
RefSeq - 1034606748
RefSeq - 1034606750
RefSeq - 260593725
RefSeq - 42544169
RefSeq - 4503599
RefSeq - 530415960
RefSeq - 1034606735
RefSeq - 530415964
RefSeq - 530415966
RefSeq - 768007297
RefSeq - NC_000019.10
RefSeq - NG_015839.2
RefSeq - NP_001159521.1
RefSeq - NP_001974.1
RefSeq - NP_973730.1
RefSeq - XP_005258691.1
RefSeq - XP_005258692.1
RefSeq - XP_005258693.1
RefSeq - XP_005258694.1
RefSeq - XP_011524912.1
RefSeq - XP_016881948.1
RefSeq - XP_016881949.1
RefSeq - XP_016881950.1
RefSeq - XP_016881951.1
RefSeq - XP_016881952.1
RefSeq - XP_016881953.1
RefSeq - XP_016881954.1
RefSeq - XP_016881955.1
RefSeq - XM_017026464.1
RefSeq - XM_017026465.1
RefSeq - NM_001166049.1
RefSeq - NM_001983.3
RefSeq - NM_202001.2
RefSeq - XM_017026466.1
RefSeq - XR_001753632.1
RefSeq - XR_001753631.1
RefSeq - XM_005258634.1
RefSeq - XM_005258635.2
RefSeq - XM_005258636.4
RefSeq - XM_005258637.1
RefSeq - XM_011526610.2
RefSeq - XM_017026459.1
RefSeq - XM_017026460.2
RefSeq - XM_017026461.1
RefSeq - XM_017026462.1
RefSeq - XM_017026463.1
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSG00000012061 to get all the annotations available for this gene.


Gene Ontology (GO)
nitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcell cyclecellular response to stimuluscellular developmental processagingcellular component organizationcellular component biogenesisanatomical structure developmentmulticellular organism reproductionresponse to external stimulusresponse to chemicalresponse to abiotic stimulusregulation of biological qualitydevelopmental growthimmune responseproduction of molecular mediator of immune responsecell activationimmune effector processnitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcell cyclecellular response to stimuluscellular developmental processagingcellular component organizationcellular component biogenesisanatomical structure developmentmulticellular organism reproductionresponse to external stimulusresponse to chemicalresponse to abiotic stimulusregulation of biological qualitydevelopmental growthimmune responseproduction of molecular mediator of immune responsecell activationimmune effector processnitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcell cyclecellular response to stimuluscellular developmental processagingcellular component organizationcellular component biogenesisanatomical structure developmentmulticellular organism reproductionresponse to external stimulusresponse to chemicalresponse to abiotic stimulusregulation of biological qualitydevelopmental growthimmune responseproduction of molecular mediator of immune responsecell activationimmune effector processnitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcell cyclecellular response to stimuluscellular developmental processagingcellular component organizationcellular component biogenesisanatomical structure developmentmulticellular organism reproductionresponse to external stimulusresponse to chemicalresponse to abiotic stimulusregulation of biological qualitydevelopmental growthimmune responseproduction of molecular mediator of immune responsecell activationimmune effector processnitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcell cyclecellular response to stimuluscellular developmental processagingcellular component organizationcellular component biogenesisanatomical structure developmentmulticellular organism reproductionresponse to external stimulusresponse to chemicalresponse to abiotic stimulusregulation of biological qualitydevelopmental growthimmune responseproduction of molecular mediator of immune responsecell activationimmune effector processnitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcell cyclecellular response to stimuluscellular developmental processagingcellular component organizationcellular component biogenesisanatomical structure developmentmulticellular organism reproductionresponse to external stimulusresponse to chemicalresponse to abiotic stimulusregulation of biological qualitydevelopmental growthimmune responseproduction of molecular mediator of immune responsecell activationimmune effector processnitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcell cyclecellular response to stimuluscellular developmental processagingcellular component organizationcellular component biogenesisanatomical structure developmentmulticellular organism reproductionresponse to external stimulusresponse to chemicalresponse to abiotic stimulusregulation of biological qualitydevelopmental growthimmune responseproduction of molecular mediator of immune responsecell activationimmune effector processnitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcell cyclecellular response to stimuluscellular developmental processagingcellular component organizationcellular component biogenesisanatomical structure developmentmulticellular organism reproductionresponse to external stimulusresponse to chemicalresponse to abiotic stimulusregulation of biological qualitydevelopmental growthimmune responseproduction of molecular mediator of immune responsecell activationimmune effector processnitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcell cyclecellular response to stimuluscellular developmental processagingcellular component organizationcellular component biogenesisanatomical structure developmentmulticellular organism reproductionresponse to external stimulusresponse to chemicalresponse to abiotic stimulusregulation of biological qualitydevelopmental growthimmune responseproduction of molecular mediator of immune responsecell activationimmune effector processnitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcell cyclecellular response to stimuluscellular developmental processagingcellular component organizationcellular component biogenesisanatomical structure developmentmulticellular organism reproductionresponse to external stimulusresponse to chemicalresponse to abiotic stimulusregulation of biological qualitydevelopmental growthimmune responseproduction of molecular mediator of immune responsecell activationimmune effector processnitrognitrogen compound metabolic processresponresponse to stresscellulcellular metabolic processprimarprimary metabolic processorganiorganic substance metabolic processcell ccell cyclecellulcellular response to stimuluscellulcellular developmental processagingagingcellulcellular component organizationcellulcellular component biogenesisanatomanatomical structure developmentmulticmulticellular organism reproductionresponresponse to external stimulusresponresponse to chemicalresponresponse to abiotic stimulusregularegulation of biological qualitydevelodevelopmental growthimmuneimmune responseproducproduction of molecular mediator of immune responsecell acell activationimmuneimmune effector process
catalytic activity, acting on DNAhydrolase activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingcatalytic activity, acting on DNAhydrolase activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingcatalytic activity, acting on DNAhydrolase activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingcatalytic activity, acting on DNAhydrolase activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingcatalytic activity, acting on DNAhydrolase activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingcatalytic activity, acting on DNAhydrolase activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingcatalytic activity, acting on DNAhydrolase activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingcatalytic activity, acting on DNAhydrolase activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingcatalytic activity, acting on DNAhydrolase activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingcatalytic activity, acting on DNAhydrolase activityprotein bindingorganic cyclic compound bindingheterocyclic compound bindingcatalytic activity, acting ocatalytic activity, acting on DNAhydrolase activityhydrolase activityprotein bindingprotein bindingorganic cyclic compound bindorganic cyclic compound bindingheterocyclic compound bindinheterocyclic compound binding
cellprotein-containing complexorganellemembrane-enclosed lumencellprotein-containing complexorganellemembrane-enclosed lumencellprotein-containing complexorganellemembrane-enclosed lumencellprotein-containing complexorganellemembrane-enclosed lumencellprotein-containing complexorganellemembrane-enclosed lumencellprotein-containing complexorganellemembrane-enclosed lumencellprotein-containing complexorganellemembrane-enclosed lumencellprotein-containing complexorganellemembrane-enclosed lumencellprotein-containing complexorganellemembrane-enclosed lumencellprotein-containing complexorganellemembrane-enclosed lumencellcellprotein-containing complexprotein-containing complexorganelleorganellemembrane-enclosed lumenmembrane-enclosed lumen
TypeGO IDTermEv.Code
 biological_processGO:0000710 meiotic mismatch repair IBA
 biological_processGO:0000720 pyrimidine dimer repair by nucleotide-excision repair IEA
 biological_processGO:0001302 replicative cell aging IEA
 biological_processGO:0006281 DNA repair IMP
 biological_processGO:0006283 transcription-coupled nucleotide-excision repair TAS
 biological_processGO:0006289 nucleotide-excision repair IGI
 biological_processGO:0006293 nucleotide-excision repair, preincision complex stabilization TAS
 biological_processGO:0006295 nucleotide-excision repair, DNA incision, 3"-to lesion IMP
 biological_processGO:0006296 nucleotide-excision repair, DNA incision, 5"-to lesion TAS
 biological_processGO:0006303 double-strand break repair via nonhomologous end joining IMP
 biological_processGO:0006310 DNA recombination IGI
 biological_processGO:0006312 mitotic recombination IMP
 biological_processGO:0006949 syncytium formation IEA
 biological_processGO:0006979 response to oxidative stress IMP
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0009650 UV protection IEA
 biological_processGO:0009744 response to sucrose IEA
 biological_processGO:0010165 response to X-ray IEA
 biological_processGO:0010259 multicellular organism aging IEA
 biological_processGO:0032205 negative regulation of telomere maintenance IMP
 biological_processGO:0033683 nucleotide-excision repair, DNA incision TAS
 biological_processGO:0035166 post-embryonic hemopoiesis IEA
 biological_processGO:0035264 multicellular organism growth IEA
 biological_processGO:0035902 response to immobilization stress IEA
 biological_processGO:0036297 interstrand cross-link repair TAS
 biological_processGO:0045190 isotype switching IEA
 biological_processGO:0046686 response to cadmium ion IEA
 biological_processGO:0048477 oogenesis IEA
 biological_processGO:0048568 embryonic organ development IEA
 biological_processGO:0061819 telomeric DNA-containing double minutes formation IMP
 biological_processGO:0070911 global genome nucleotide-excision repair TAS
 biological_processGO:0070914 UV-damage excision repair IBA
 biological_processGO:0090656 t-circle formation ISS
 biological_processGO:1904431 positive regulation of t-circle formation ISS
 biological_processGO:1905765 negative regulation of protection from non-homologous end joining at telomere IMP
 cellular_componentGO:0000109 nucleotide-excision repair complex IDA
 cellular_componentGO:0000110 nucleotide-excision repair factor 1 complex IDA
 cellular_componentGO:0000784 nuclear chromosome, telomeric region IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005669 transcription factor TFIID complex IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0070522 ERCC4-ERCC1 complex IDA
 molecular_functionGO:0000014 single-stranded DNA endodeoxyribonuclease activity IDA
 molecular_functionGO:0001094 TFIID-class transcription factor binding IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003684 damaged DNA binding IDA
 molecular_functionGO:0003697 single-stranded DNA binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IPI
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:1990599 3" overhang single-stranded DNA endodeoxyribonuclease activity IMP


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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