ENSDARG00000000767


Danio rerio

Features
Gene ID: ENSDARG00000000767
  
Biological name :spi1b
  
Synonyms : spi1b / Spi-1 proto-oncogene b
  
Possible biological names infered from orthology : P17433 / P17947 / SPI1 / Spi-1 proto-oncogene / spleen focus forming virus (SFFV) proviral integration oncogene
  
Species: Danio rerio
  
Chr. number: 7
Strand: -1
Band:
Gene start: 32644673
Gene end: 32659353
  
Corresponding Affymetrix probe sets: Dr.7612.1.A1_at (Zebrafish Array)   DrAffx.1.56.S1_at (Zebrafish Array)   NM_198062_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000029369
Ensembl peptide - ENSDARP00000087711
Ensembl peptide - ENSDARP00000109500
NCBI entrez gene - 30117     See in Manteia.
RefSeq - NM_198062
RefSeq - XM_005168848
RefSeq - NM_001328368
RefSeq - NM_001328369
RefSeq Peptide - NP_001315297
RefSeq Peptide - NP_001315298
RefSeq Peptide - NP_932328
swissprot - Q6PHV7
swissprot - Q78AM8
swissprot - Q8AW41
swissprot - F1R668
ZFIN ID - ZDB-GENE-980526-164
Ensembl - ENSDARG00000000767
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SPI1ENSGALG00000008127Gallus gallus
 SPI1ENSG00000066336Homo sapiens
 Spi1ENSMUSG00000002111Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
spi1a / Spi-1 proto-oncogene a / SPI1* / P17947* / P17433* / Spi-1 proto-oncogene* / spleen focus forming virus (SFFV) proviral integration oncogene*ENSDARG0000006779738
spic / Spi-C transcription factor (Spi-1/PU.1 related) / Q8N5J4* / Q6P3D7* / Spi-C transcription factor* / Transcription factor Spi-C *ENSDARG0000001243522
spi2 / Spi-2 proto-oncogeneENSDARG0000008743820


Protein motifs (from Interpro)
Interpro ID Name
 IPR000418  Ets domain
 IPR011991  ArsR-like helix-turn-helix domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0030099 myeloid cell differentiation IMP
 biological_processGO:0030223 neutrophil differentiation IMP
 biological_processGO:0030225 macrophage differentiation IMP
 biological_processGO:0045647 negative regulation of erythrocyte differentiation IMP
 biological_processGO:0045659 negative regulation of neutrophil differentiation IMP
 biological_processGO:0048821 erythrocyte development IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain lacks all parts of type microglial cell , abnormal
brain apoptotic cell clearance decreased occurrence , abnormal
brain apoptotic process decreased occurrence , abnormal
Show

 ZFA:0000014 dorsal aorta dorsal aorta closed , abnormal
Show

 ZFA:0000040 median fin fold median fin fold morphology , abnormal
median fin fold degenerate , abnormal
Show

 ZFA:0000084 yolk yolk lacks parts or has fewer parts of type granulocyte , abnormal
yolk lacks parts or has fewer parts of type macrophage , abnormal
Show

 ZFA:0000094 blood island blood island lacks parts or has fewer parts of type granulocyte , abnormal
blood island lacks parts or has fewer parts of type macrophage , abnormal
blood island macrophage decreased amount , abnormal
blood island neutrophil decreased amount , abnormal
Show

 ZFA:0000105 epidermis epidermis disorganized , abnormal
Show

 ZFA:0000106 extension extension degenerate , abnormal
Show

 ZFA:0000123 liver liver size , ameliorated
liver macrophage amount , ameliorated
liver neutrophil increased amount , abnormal
liver neutrophil amount , ameliorated
Show

 ZFA:0000186 common cardinal vein common cardinal vein blood vessel endothelial cell increased amount , abnormal
Show

 ZFA:0000243 neuromast neuromast epithelium position , ameliorated
Show

 ZFA:0000554 olfactory epithelium olfactory epithelium position , ameliorated
Show

 ZFA:0001058 caudal fin caudal fin regenerating fin increased amount , abnormal
Show

 ZFA:0001094 whole organism whole organism lacks all parts of type macrophage , abnormal
whole organism decreased life span , abnormal
whole organism dead , abnormal
whole organism viability , abnormal
whole organism decreased life span , ameliorated
whole organism decreased life span , exacerbated
Show

 ZFA:0001114 head head epidermis position , ameliorated
Show

 ZFA:0001269 regenerating fin regenerating fin decreased length , abnormal
regenerating fin apoptotic process occurrence , ameliorated
regenerating fin apoptotic process increased occurrence , abnormal
Show

 ZFA:0005028 ventral wall of dorsal aorta ventral wall of dorsal aorta hematopoietic multipotent progenitor cell decreased amount , abnormal
Show

 ZFA:0005145 muscle muscle degenerate , abnormal
Show

 ZFA:0009015 erythroid progenitor cell erythroid progenitor cell increased amount , abnormal
Show

 ZFA:0009034 epithelial cell epithelial cell position , ameliorated
Show

 ZFA:0009077 microglial cell microglial cell decreased amount , abnormal
microglial cell absent , abnormal
Show

 ZFA:0009114 muscle cell muscle cell cell wall repair process quality , abnormal
Show

 ZFA:0009141 macrophage macrophage decreased amount , abnormal
macrophage absent , abnormal
Show

 ZFA:0009159 mucus secreting cell mucus secreting cell decreased amount , abnormal
mucus secreting cell proliferative , abnormal
Show

 ZFA:0009301 dopaminergic neuron dopaminergic neuron decreased amount , abnormal
Show

 ZFA:0009309 leukocyte leukocyte absent , abnormal
Show

 ZFA:0009324 myeloid cell myeloid cell decreased amount , abnormal
myeloid cell absent , abnormal
Show

 ZFA:0009325 erythroid lineage cell erythroid lineage cell increased amount , abnormal
Show

 ZFA:0009327 neutrophil neutrophil decreased amount , abnormal
neutrophil absent , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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