ENSMUSG00000002111


Mus musculus

Features
Gene ID: ENSMUSG00000002111
  
Biological name :Spi1
  
Synonyms : P17433 / Spi1 / spleen focus forming virus (SFFV) proviral integration oncogene
  
Possible biological names infered from orthology : P17947 / Spi-1 proto-oncogene
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: E1
Gene start: 91082390
Gene end: 91115756
  
Corresponding Affymetrix probe sets: 10473809 (MoGene1.0st)   1418747_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000130368
Ensembl peptide - ENSMUSP00000002180
Ensembl peptide - ENSMUSP00000128457
NCBI entrez gene - 20375     See in Manteia.
MGI - MGI:98282
RefSeq - XM_017316733
RefSeq - NM_011355
RefSeq - XM_006499038
RefSeq - XM_011239397
RefSeq Peptide - NP_035485
swissprot - P17433
swissprot - Q3U5L4
swissprot - E9QAI9
swissprot - E9Q6W1
Ensembl - ENSMUSG00000002111
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 spi1aENSDARG00000067797Danio rerio
 spi1bENSDARG00000000767Danio rerio
 SPI1ENSGALG00000008127Gallus gallus
 SPI1ENSG00000066336Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Spib / O35906 / Transcription factor Spi-B / Q01892* / AC020909.1* / Spi-B transcription factor*ENSMUSG0000000819336
Spic / Q6P3D7 / Transcription factor Spi-C / Q8N5J4* / Spi-C transcription factor*ENSMUSG0000000435924


Protein motifs (from Interpro)
Interpro ID Name
 IPR000418  Ets domain
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0001944 vasculature development IMP
 biological_processGO:0002320 lymphoid progenitor cell differentiation IMP
 biological_processGO:0002573 myeloid leukocyte differentiation IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IDA
 biological_processGO:0030098 lymphocyte differentiation IDA
 biological_processGO:0030218 erythrocyte differentiation IMP
 biological_processGO:0030225 macrophage differentiation IDA
 biological_processGO:0030851 granulocyte differentiation IDA
 biological_processGO:0035019 somatic stem cell population maintenance IDA
 biological_processGO:0043011 myeloid dendritic cell differentiation IMP
 biological_processGO:0043966 histone H3 acetylation IEA
 biological_processGO:0044027 hypermethylation of CpG island IEA
 biological_processGO:0045347 negative regulation of MHC class II biosynthetic process IDA
 biological_processGO:0045646 regulation of erythrocyte differentiation IEA
 biological_processGO:0045814 negative regulation of gene expression, epigenetic IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0060033 anatomical structure regression IMP
 biological_processGO:0061614 pri-miRNA transcription by RNA polymerase II IEA
 biological_processGO:0071361 cellular response to ethanol IEA
 biological_processGO:0090241 negative regulation of histone H4 acetylation IEA
 biological_processGO:1902262 apoptotic process involved in blood vessel morphogenesis IMP
 biological_processGO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II IDA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005667 transcription factor complex IC
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0000982 transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001047 core promoter binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding IPI
 molecular_functionGO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity ISO
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IDA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0051525 NFAT protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000067 osteopetrosis "excessive formation of dense trabecular bone and excessive calcified cartilage formation; may lead to anemia and extramedullary hematopoiesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Mapttm1Hnd/Mapttm1Hnd
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000121 failure of tooth eruption "inability of the teeth to grow into the oral cavity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Mapttm1Hnd/Mapttm1Hnd
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000136 abnormal microglial cell morphology "anomalous structure, number, or composition of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, J:71688]
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Allelic Composition: Spi1tm1Ram/Spi1tm1Ram
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Spi1tm1Sing/Spi1tm1Sing
Genetic Background: involves: 129S/SvEv

 MP:0000215 absent erythrocytes "lack of mature red blood cells" [J:23061]
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Allelic Composition: Spi1tm1.2Nutt/Spi1tm1.2Nutt,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spi1tm1.3Dgt/Spi1tm1.3Dgt
Genetic Background: involves: 129 * BALB/c * C57BL/6

 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spi1tm1Ram/Spi1tm1Ram
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000239 deficiency of myeloid colony forming progenitor cells "lack of precursors of the myeloid cell types" [J:60630, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Mef2ctm1Eno/Mef2ctm1Eno
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Spi1tm1.2Nutt/Spi1tm1.2Nutt,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Spi1tm1.1Nutt/Spi1tm1.1Nutt
Genetic Background: involves: C57BL/6 * BALB/cJ

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Spi1tm1.2Nutt/Spi1tm1.2Nutt,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Cav1tm1Kur/Cav1tm1Kur
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Spi1tm1Kast/Spi1+
Genetic Background: B6.129S2-Spi1tm1Kast

Allelic Composition: Spi1tm1Sing/Spi1tm1Sing
Genetic Background: involves: 129S/SvEv

 MP:0000321 increased bone marrow cell number "increased number of cells that make up the core cavitites of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Cav1tm1Kur/Cav1tm1Kur
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Spi1tm4.1Dgt/Spi1tm4.1Dgt
Genetic Background: B6.129(Cg)-Spi1tm4.1Dgt

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spi1tm1.2Nutt/Spi1tm1.2Nutt,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Spi1tm3Dgt/Spi1tm3Dgt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Runx1tm3Spe/Runx1tm3Spe,Spi1tm2.1Dgt/Spi1tm2.1Dgt,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0000334 decreased granulocyte number "fewer than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spi1tm1.3Dgt/Spi1tm1.3Dgt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Spi1tm1.2Dgt/Spi1tm1.2Dgt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Spi1tm1Ram/Spi1tm1Ram
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Psen1tm1Jzt/Psen1tm1Jzt
Genetic Background: involves: C57BL/6 * CBA

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Psen1tm1Jzt/Psen1tm1Jzt
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Spi1tm1.2Nutt/Spi1tm1.2Nutt,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Spi1tm1.3Dgt/Spi1tm1.3Dgt
Genetic Background: involves: 129 * BALB/c * C57BL/6

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Psen1tm1Jzt/Psen1tm1Jzt
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Spi1tm1.3Dgt/Spi1tm1.3Dgt
Genetic Background: involves: 129 * BALB/c * C57BL/6

Allelic Composition: Spi1tm1Rpd/Spi1tm1Rpd
Genetic Background: involves: 129/Sv * C57BL/6 * Black Swiss

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Psen1tm1Jzt/Psen1tm1Jzt
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Spi1tm1.3Dgt/Spi1tm1.3Dgt
Genetic Background: involves: 129 * BALB/c * C57BL/6

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
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Allelic Composition: Spi1tm1.3Dgt/Spi1tm1.3Dgt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Spi1tm1.3Dgt/Spi1tm1.3Dgt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

Allelic Composition: Spi1tm1Ram/Spi1tm1Ram
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000938 motor neuron degeneration "retrogressive impairment of function or destruction of the cells that innervate an effector (muscle or glandular) tissue" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Spi1tm1Ram/Spi1tm1Ram,Tg(SOD1*G93A)1Gur/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0000939 reduced motor neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Spi1tm1Ram/Spi1tm1Ram,Tg(SOD1*G93A)1Gur/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Mapttm1Hnd/Mapttm1Hnd
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001286 abnormal eye development "malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]
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Allelic Composition: Egr1tm1Pch/Egr1tm1Pch
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Spi1tm1Ram/Spi1+
Genetic Background: involves: 129S2/SvPas

 MP:0001289 persistence of hyaloid capillary system "failure of the degeneration of the transient vascular system of the eye during development" [J:49840]
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Allelic Composition: Egr1tm1Pch/Egr1tm1Pch
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Spi1tm1Ram/Spi1+
Genetic Background: involves: 129S2/SvPas

 MP:0001545 abnormal hematopoietic system physiology "anomalous function of the fluid and/or its suspended elements that circulate(s) through the heart, arteries, capillaries, and veins" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nlgn2tm1Bros/Nlgn2tm1Bros,Nlgn3tm1Bros/Nlgn3tm1Bros
Genetic Background: Not Specified

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Il1rntm1Dih/Il1rntm1Dih
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0001586 abnormal erythrocyte count "altered number of red blood cells per volume in the bloodstream" [J:53370]
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Allelic Composition: Psen1tm1Jzt/Psen1tm1Jzt
Genetic Background: involves: C57BL/6 * CBA

 MP:0001601 abnormal myelopoiesis "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Mapttm1Hnd/Mapttm1Hnd
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001602 impaired myelopoiesis "atypical process of bone marrow cell formation and/or the formation of bone marrow-derived blood cells with the result of fewer of these cells being formed" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Mapttm1Hnd/Mapttm1Hnd
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001603 failure of myelopoiesis "missing the process of bone marrow cell formation and/or the formation of bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc, J:60896]
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Allelic Composition: Cav1tm1Kur/Cav1tm1Kur
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Spi1tm1Ram/Spi1tm1Ram
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001802 arrested B cell development "inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]
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Allelic Composition: Spi1tm1.3Dgt/Spi1tm1.3Dgt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

Allelic Composition: Spi1tm1Rpd/Spi1tm1Rpd
Genetic Background: involves: 129/Sv * C57BL/6 * Black Swiss

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Psen1tm1Jzt/Psen1tm1Jzt
Genetic Background: involves: C57BL/6 * CBA

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Psen1tm1Jzt/Psen1tm1Jzt
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Spi1tm1.3Dgt/Spi1tm1.3Dgt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

Allelic Composition: Spi1tm1.3Dgt/Spi1tm1.3Dgt
Genetic Background: involves: 129 * BALB/c * C57BL/6

 MP:0002026 leukemia "progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Psen1tm1Jzt/Psen1tm1Jzt
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Spi1tm1.3Dgt/Spi1tm1.3Dgt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

Allelic Composition: Spi1tm1.3Dgt/Spi1tm1.3Dgt
Genetic Background: involves: 129 * BALB/c * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Psen1tm1Jzt/Psen1tm1Jzt
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Spi1tm1.3Dgt/Spi1tm1.3Dgt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

Allelic Composition: Spi1tm1.3Dgt/Spi1tm1.3Dgt
Genetic Background: involves: 129 * BALB/c * C57BL/6

Allelic Composition: Spi1tm1Ram/Spi1tm1Ram
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Spi1tm1Ram/Spi1tm1Ram,Tg(SOD1*G93A)1Gur/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Psen1tm1Jzt/Psen1tm1Jzt
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Spi1tm1.3Dgt/Spi1tm1.3Dgt
Genetic Background: involves: 129 * BALB/c * C57BL/6

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Il1rntm1Dih/Il1rntm1Dih
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Spi1tm1Sing/Spi1+,Spibtm1Mcs/Spibtm1Mcs
Genetic Background: involves: 129S/SvEv * 129X1/SvJ

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Il1rntm1Dih/Il1rntm1Dih
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Spi1tm1Ram/Spi1tm1Ram
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mchr1tm1Dgam/Mchr1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Spi1tm1.2Dgt/Spi1tm1.2Dgt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002182 abnormal astrocyte morphology "anomalous structure, number or compostion of one of the large neuroglia cells of nervous tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Spi1tm1Ram/Spi1tm1Ram
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002359 abnormal spleen germinal center morphology "anomalous structure or formation of the area of the spleen in which activated follicles are located" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Spi1tm1Sing/Spi1tm1Sing,Spibtm1Mcs/Spibtm1Mcs
Genetic Background: involves: 129S/SvEv * 129X1/SvJ

 MP:0002397 abnormal bone marrow morphology "structural anomalies in the soft tissue that fills the cavities of bones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Psen1tm1Jzt/Psen1tm1Jzt
Genetic Background: involves: C57BL/6 * CBA

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spi1tm1.2Nutt/Spi1tm1.2Nutt,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0002407 abnormal double-negative T cell "anomalous structure, development, or number of the subset of T cells found in the thymus that express neither CD4 nor CD8" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Spi1tm1.3Dgt/Spi1tm1.3Dgt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

 MP:0002415 abnormal neutrophil morphology/development "anomalous structure, differentiation, or number of the granular leukocytes that have a three- to five-lobed nucleus and a cytoplasm that contains inconspicuous granules stainable by neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spi1tm1Ram/Spi1tm1Ram
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002416 abnormal proerythroblast morphology/development "anomalous structure, formation, or numbers of the immature, nucleated erythrocyte precursors that give rise to reticulocytes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spi1tm1.3Dgt/Spi1tm1.3Dgt
Genetic Background: involves: 129 * BALB/c * C57BL/6

 MP:0002429 abnormal blood cell morphology/development "anomalous structure, differentiation, or number of any of the cells found in the blood" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nlgn2tm1Bros/Nlgn2tm1Bros,Nlgn3tm1Bros/Nlgn3tm1Bros
Genetic Background: Not Specified

Allelic Composition: Spi1tm2.1Dgt/Spi1tm2Dgt,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Spi1tm2Dgt/Spi1tm2Dgt,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Spi1tm2Dgt/Spi1tm2Dgt
Genetic Background: B6.Cg-Spi1tm2Dgt

 MP:0002441 abnormal granulocyte morphology/development "anomalous structure, differentiation, or number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Il1rntm1Dih/Il1rntm1Dih
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0002458 abnormal B cell number "deviation from the normal number of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spi1tm1Ram/Spi1tm1Ram
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spi1tm1.3Dgt/Spi1tm1.3Dgt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

 MP:0002620 abnormal monocyte morphology "anomalous structure, number, or development of the white blood cells that are precursors to macrophages" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spi1tm1Sing/Spi1tm1Sing
Genetic Background: involves: 129S/SvEv

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Spi1tm1.3Dgt/Spi1tm1.3Dgt
Genetic Background: involves: 129 * BALB/c * C57BL/6

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
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Allelic Composition: Spi1tm4.1Dgt/Spi1tm4.1Dgt
Genetic Background: B6.129(Cg)-Spi1tm4.1Dgt

 MP:0003884 decreased macrophage count "fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Egr1tm1Pch/Egr1tm1Pch
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Spi1tm1Ram/Spi1tm1Ram
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003944 abnormal T cell subpopulation ratio "deviation from the standard ratios of T cell subpopulations (e.g. double positive to single positive ratio) compared to control samples" [mberry:Melissa Berry, Genetics Resources Curator]
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Allelic Composition: Spi1tm1.3Dgt/Spi1tm1.3Dgt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

 MP:0004023 abnormal chromosome number "chromosome count is other than the expected diploid chromosome number" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Spi1tm1.3Dgt/Spi1tm1.3Dgt
Genetic Background: involves: 129 * BALB/c * C57BL/6

 MP:0004809 increased hematopoietic stem cell number "greater cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Spi1tm1Kast/Spi1+
Genetic Background: B6.129S2-Spi1tm1Kast

Allelic Composition: Spi1tm4.1Dgt/Spi1tm4.1Dgt
Genetic Background: B6.129(Cg)-Spi1tm4.1Dgt

 MP:0004810 decreased hematopoietic stem cell number "reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nlgn2tm1Bros/Nlgn2tm1Bros,Nlgn3tm1Bros/Nlgn3tm1Bros
Genetic Background: Not Specified

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Spi1tm1.3Dgt/Spi1tm1.3Dgt
Genetic Background: involves: 129 * BALB/c * C57BL/6

Allelic Composition: Runx1tm3Spe/Runx1tm3Spe,Spi1tm2.1Dgt/Spi1tm2.1Dgt,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0004956 decreased thymus weight "reduction in the average weight of the primary lymphoid organ that is required for maturation of T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Runx1tm3Spe/Runx1tm3Spe,Spi1tm2.1Dgt/Spi1tm2.1Dgt,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0004977 increased B-1 B cell number "greater number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Spi1tm1.3Dgt/Spi1tm1.3Dgt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spi1tm1.3Dgt/Spi1tm1.3Dgt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spi1tm1.3Dgt/Spi1tm1.3Dgt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Psen1tm1Jzt/Psen1tm1Jzt
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Spi1tm1.2Nutt/Spi1tm1.2Nutt,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Spi1tm1Sing/Spi1+,Spibtm1Mcs/Spibtm1Mcs
Genetic Background: involves: 129S/SvEv * 129X1/SvJ

Allelic Composition: Spi1tm1.3Dgt/Spi1tm1.3Dgt
Genetic Background: involves: 129 * BALB/c * C57BL/6

Allelic Composition: Spi1tm3Dgt/Spi1tm3Dgt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Runx1tm3Spe/Runx1tm3Spe,Spi1tm2.1Dgt/Spi1tm2.1Dgt,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spi1tm1.3Dgt/Spi1tm1.3Dgt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

 MP:0005022 abnormal immature B cell "anomalous structure, development, or number of the cells of the B lymphocyte lineage that have undergone VDJ rearragnement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Spi1tm1Sing/Spi1+,Spibtm1Mcs/Spibtm1Mcs
Genetic Background: involves: 129S/SvEv * 129X1/SvJ

 MP:0005044 sepsis "presence of various pathogenic organisms, or their toxins, in the blood or tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:82434]
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Allelic Composition: Spi1tm1Ram/Spi1tm1Ram
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005089 decreased double-negative T cell count "reduced numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8 " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Spi1tm3Dgt/Spi1tm3Dgt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Spi1tm3Dgt/Spi1tm3Dgt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Spi1tm1Ram/Spi1tm1Ram
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spi1tm1Sing/Spi1+,Spibtm1Mcs/Spibtm1Mcs
Genetic Background: involves: 129S/SvEv * 129X1/SvJ

Allelic Composition: Spi1tm1Sing/Spi1+,Spibtm1Mcs/Spib+
Genetic Background: involves: 129S/SvEv * 129X1/SvJ

 MP:0005141 liver hyperplasia "increased size of liver due to increased hepatocyte cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33827]
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Allelic Composition: Spi1tm1.3Dgt/Spi1tm1.3Dgt
Genetic Background: involves: 129 * BALB/c * C57BL/6

Allelic Composition: Spi1tm1Rpd/Spi1tm1Rpd
Genetic Background: involves: 129/Sv * C57BL/6 * Black Swiss

 MP:0005460 abnormal leukopoiesis "anomalous process of generating white blood cells (leukocytes) from the pluripotent hematopoietic stem cells of the bone marrow; two significant pathways generate various types of leukocytes: myelopoiesis, in which leukocytes in the blood are derived from myeloid stem cells, and lymphopoiesis, in which leukocytes of the lymphatic system (lymphocytes) are generated from lymphoid stem cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Spi1tm1Sing/Spi1tm1Sing
Genetic Background: involves: 129S/SvEv

 MP:0006387 abnormal T cell number "deviation from the normal count of T cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Spi1tm1Ram/Spi1tm1Ram
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Spi1tm1Sing/Spi1tm1Sing
Genetic Background: involves: 129S/SvEv

Allelic Composition: Spi1tm1Rpd/Spi1tm1Rpd
Genetic Background: involves: 129/Sv * C57BL/6 * Black Swiss

Allelic Composition: Spi1tm1.1Rpd/Spi1tm1.1Rpd
Genetic Background: involves: 129/Sv * Black Swiss * FVB/N

 MP:0008071 absent B cells "absence of lymphocytes that expresses membrane-bound antibody, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cav1tm1Kur/Cav1tm1Kur
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Spi1tm1Ram/Spi1tm1Ram
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Spi1tm1Ram/Spi1tm1Ram
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008111 abnormal granulocyte differentiaton "atypical production of or inability to produce leukocytes that have abundant granules in the cytoplasm, including basophils, neutrophils, and eosinophils" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Spi1tm1.2Nutt/Spi1tm1.2Nutt,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0008113 abnormal macrophage differentiation "atypical production of or inability to produce the large mononuclear phagocytes which differentiate from monocytes, are typically resident in a particular tissue, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells" [CL:0000235, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Spi1tm1Ram/Spi1tm1Ram
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008168 decreased B-1a cell number "reduced number of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604]
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Allelic Composition: Spi1tm1.3Dgt/Spi1tm1.3Dgt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

 MP:0008169 increased B-1b cell number "greater number of the B-1 B cell subset not bearing the CD5 surface marker, but having other phenotypic attributes of a B-1 B cell" [CL:0000821, PMID:11861604]
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Allelic Composition: Spi1tm1.3Dgt/Spi1tm1.3Dgt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

 MP:0008208 decreased pro-B cell number "reduced number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Spi1tm1.3Dgt/Spi1tm1.3Dgt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Spi1tm1.3Dgt/Spi1tm1.3Dgt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Spi1tm1.3Dgt/Spi1tm1.3Dgt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

 MP:0008212 absent mature B cells "absence of the mature form of a B cell, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Spi1tm1Ram/Spi1tm1Ram
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008474 absent spleen germinal center "absence of the area of the spleen secondary B follicle where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Spi1tm1Sing/Spi1+,Spibtm1Mcs/Spibtm1Mcs
Genetic Background: involves: 129S/SvEv * 129X1/SvJ

 MP:0008477 decreased spleen red pulp amount "reduction in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Spi1tm1Ram/Spi1tm1Ram
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008782 increased B cell apoptosis "increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Spi1tm1Sing/Spi1+,Spibtm1Mcs/Spibtm1Mcs
Genetic Background: involves: 129S/SvEv * 129X1/SvJ

 MP:0010763 abnormal hematopoietic stem cell physiology "any functional anomaly or number of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; HSCs give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Spi1tm4.1Dgt/Spi1tm4.1Dgt
Genetic Background: B6.129(Cg)-Spi1tm4.1Dgt

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Spi1tm1.1Rpd/Spi1tm1.1Rpd
Genetic Background: involves: 129/Sv * Black Swiss * FVB/N

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Spi1tm1Rpd/Spi1tm1Rpd
Genetic Background: involves: 129/Sv * C57BL/6 * Black Swiss

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Cav1tm1Kur/Cav1tm1Kur
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Spi1tm1.3Nutt/Spi1tm1.3Nutt
Genetic Background: C57BL/6-Sfpi1tm1.3Nutt

Allelic Composition: Spi1tm1Ram/Spi1tm1Ram
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Nlgn2tm1Bros/Nlgn2tm1Bros,Nlgn3tm1Bros/Nlgn3tm1Bros
Genetic Background: Not Specified

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Spi1tm1Sing/Spi1tm1Sing
Genetic Background: involves: 129S/SvEv

Allelic Composition: Spi1tm1Sing/Spi1tm1Sing,Spibtm1Mcs/Spibtm1Mcs
Genetic Background: involves: 129S/SvEv * 129X1/SvJ

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Rad9atm1.1(KOMP)Wtsi/Rad9atm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Rad9atm1.1(KOMP)Wtsi/Bay

 MP:0011241 abnormal fetal derived definitive erythrocyte cell number "anomaly in the number of a fetal liver derived enucleated erythrocytes, which mature in macrophage islands within the liver, enucleate, and then enter the bloodstream; these resemble adult erythrocytes in that they are small (3- to 6- times smaller than primitive erythrocytes) and produce adult hemoglobins" [CL:0002357, PMID:18282515]
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Allelic Composition: Cav1tm1Kur/Cav1tm1Kur
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011902 increased hematopoietic stem cell proliferation "increase in the expansion rate of a hematopoietic stem cell population by cell division" [MGI:csmith]
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Allelic Composition: Spi1tm4.1Dgt/Spi1tm4.1Dgt
Genetic Background: B6.129(Cg)-Spi1tm4.1Dgt

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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