ENSMUSG00000004359


Mus musculus

Features
Gene ID: ENSMUSG00000004359
  
Biological name :Spic
  
Synonyms : Q6P3D7 / Spic / Transcription factor Spi-C
  
Possible biological names infered from orthology : Q8N5J4 / Spi-C transcription factor
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: C1
Gene start: 88674772
Gene end: 88685015
  
Corresponding Affymetrix probe sets: 10371662 (MoGene1.0st)   1418555_x_at (Mouse Genome 430 2.0 Array)   1449134_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000004473
Ensembl peptide - ENSMUSP00000118799
Ensembl peptide - ENSMUSP00000114328
NCBI entrez gene - 20728     See in Manteia.
MGI - MGI:1341168
RefSeq - NM_011461
RefSeq Peptide - NP_035591
swissprot - D6RE28
swissprot - D3YYM5
swissprot - Q6P3D7
Ensembl - ENSMUSG00000004359
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 spicENSDARG00000012435Danio rerio
 SPICENSGALG00000027209Gallus gallus
 SPICENSG00000166211Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Spib / O35906 / Transcription factor Spi-B / Q01892* / AC020909.1* / Spi-B transcription factor*ENSMUSG0000000819328
Spi1 / P17433 / spleen focus forming virus (SFFV) proviral integration oncogene / P17947* / Spi-1 proto-oncogene*ENSMUSG0000000211127


Protein motifs (from Interpro)
Interpro ID Name
 IPR000418  Ets domain
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001824 blastocyst development IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IMP
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IMP
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001798 impaired macrophage phagocytosis "reduced ability of these phagocytic cells to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il2rgtm1Cgn/Il2rgtm1Cgn,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Spictm1Kmm/Spictm1Kmm
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Plgtm1.1Fjc/Plgtm1.1Fjc
Genetic Background: involves: C57BL/6 * C57BL/6JJcl

 MP:0002446 abnormal macrophage morphology "anomalous structure, number, or composition of the large mononuclear phagocytic cells found in most tissues of the body" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il2rgtm1Cgn/Il2rgtm1Cgn,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Spictm1Kmm/Spictm1Kmm
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0003884 decreased macrophage count "fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]
Show

Allelic Composition: Plgtm1.1Fjc/Plgtm1.1Fjc
Genetic Background: involves: C57BL/6 * C57BL/6JJcl

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il2rgtm1Cgn/Il2rgtm1Cgn,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Spictm1Kmm/Spictm1Kmm
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008809 increased spleen iron level "increase in the amount of iron present in the spleen tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il2rgtm1Cgn/Il2rgtm1Cgn,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Spictm1Kmm/Spictm1Kmm
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Il2rgtm1Cgn/Il2rgtm1Cgn,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Spictm1Kmm/Spictm1Kmm
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr