ENSG00000066336


Homo sapiens

Features
Gene ID: ENSG00000066336
  
Biological name :SPI1
  
Synonyms : P17947 / SPI1 / Spi-1 proto-oncogene
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: p11.2
Gene start: 47354860
Gene end: 47378576
  
Corresponding Affymetrix probe sets: 205312_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000227163
Ensembl peptide - ENSP00000367799
Ensembl peptide - ENSP00000438846
Ensembl peptide - ENSP00000443865
NCBI entrez gene - 6688     See in Manteia.
OMIM - 165170
RefSeq - NM_003120
RefSeq - NM_001080547
RefSeq Peptide - NP_001074016
RefSeq Peptide - NP_003111
swissprot - P17947
swissprot - F5GZ94
swissprot - F5H3K6
Ensembl - ENSG00000066336
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 spi1aENSDARG00000067797Danio rerio
 spi1bENSDARG00000000767Danio rerio
 SPI1ENSGALG00000008127Gallus gallus
 Spi1ENSMUSG00000002111Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AC020909.1ENSG0000014253940
SPIB / Q01892 / Spi-B transcription factorENSG0000026940439
SPIC / Q8N5J4 / Spi-C transcription factorENSG0000016621124


Protein motifs (from Interpro)
Interpro ID Name
 IPR000418  Ets domain
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001944 vasculature development IEA
 biological_processGO:0002320 lymphoid progenitor cell differentiation IEA
 biological_processGO:0002573 myeloid leukocyte differentiation IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0030098 lymphocyte differentiation IEA
 biological_processGO:0030218 erythrocyte differentiation IEA
 biological_processGO:0030225 macrophage differentiation IEA
 biological_processGO:0030851 granulocyte differentiation IEA
 biological_processGO:0035019 somatic stem cell population maintenance IEA
 biological_processGO:0043011 myeloid dendritic cell differentiation IEA
 biological_processGO:0043966 histone H3 acetylation IMP
 biological_processGO:0044027 hypermethylation of CpG island IDA
 biological_processGO:0045347 negative regulation of MHC class II biosynthetic process IEA
 biological_processGO:0045646 regulation of erythrocyte differentiation IMP
 biological_processGO:0045814 negative regulation of gene expression, epigenetic IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0060033 anatomical structure regression IEA
 biological_processGO:0061614 pri-miRNA transcription by RNA polymerase II IDA
 biological_processGO:0071361 cellular response to ethanol IEA
 biological_processGO:0090241 negative regulation of histone H4 acetylation IMP
 biological_processGO:1902036 regulation of hematopoietic stem cell differentiation TAS
 biological_processGO:1902262 apoptotic process involved in blood vessel morphogenesis IEA
 biological_processGO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II IEA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0000982 transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001047 core promoter binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding IEA
 molecular_functionGO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0051525 NFAT protein binding IEA


Pathways (from Reactome)
Pathway description
RUNX1 regulates transcription of genes involved in differentiation of HSCs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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