ENSDARG00000005134


Danio rerio

Features
Gene ID: ENSDARG00000005134
  
Biological name :psmd11b
  
Synonyms : F1QGH9 / proteasome 26S subunit, non-ATPase 11b / psmd11b
  
Possible biological names infered from orthology : 26S proteasome non-ATPase regulatory subunit 11 / O00231 / proteasome 26S subunit, non-ATPase 11 / PSMD11 / Q8BG32
  
Species: Danio rerio
  
Chr. number: 12
Strand: -1
Band:
Gene start: 28346722
Gene end: 28363166
  
Corresponding Affymetrix probe sets: Dr.23797.1.S1_at (Zebrafish Array)   NM_199592_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000020942
Ensembl peptide - ENSDARP00000133045
NCBI entrez gene - 322265     See in Manteia.
RefSeq - NM_199592
RefSeq Peptide - NP_955886
swissprot - F1QGH9
swissprot - A0A0R4IH84
ZFIN ID - ZDB-GENE-030131-984
Ensembl - ENSDARG00000005134
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PSMD11ENSGALG00000024112Gallus gallus
 O00231ENSG00000108671Homo sapiens
 Psmd11ENSMUSG00000017428Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
F6P3G4 / psmd11a / proteasome 26S subunit, non-ATPase 11a / O00231* / Q8BG32* / PSMD11* / proteasome 26S subunit, non-ATPase 11* / 26S proteasome non-ATPase regulatory subunit 11 *ENSDARG0000006015091
cops2 / Q6IQT4 / COP9 signalosome subunit 2 / P61201* / P61202* / COP9 signalosome complex subunit 2 *ENSDARG0000000478522


Protein motifs (from Interpro)
Interpro ID Name
 IPR000717  Proteasome component (PCI) domain
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR011991  ArsR-like helix-turn-helix domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IBA
 biological_processGO:0043248 proteasome assembly ISS
 biological_processGO:0048863 stem cell differentiation ISS
 cellular_componentGO:0000502 proteasome complex IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0008541 proteasome regulatory particle, lid subcomplex IBA
 cellular_componentGO:0022624 proteasome accessory complex ISS
 molecular_functionGO:0005198 structural molecule activity IBA


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Hedgehog on state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
Neutrophil degranulation
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
Ubiquitin-dependent degradation of Cyclin D1
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Interleukin-1 signaling
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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