ENSDARG00000005789


Danio rerio

Features
Gene ID: ENSDARG00000005789
  
Biological name :enpp1
  
Synonyms : ectonucleotide pyrophosphatase/phosphodiesterase 1 / enpp1
  
Possible biological names infered from orthology : ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform 3 / P22413
  
Species: Danio rerio
  
Chr. number: 20
Strand: 1
Band:
Gene start: 13403281
Gene end: 13521010
  
Corresponding Affymetrix probe sets: Dr.2634.1.A1_at (Zebrafish Array)   NM_001030168_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000045182
Ensembl peptide - ENSDARP00000112341
NCBI entrez gene - 562399     See in Manteia.
RefSeq - XM_005160441
RefSeq - NM_001030168
RefSeq Peptide - NP_001025339
swissprot - F6NNN9
swissprot - B0JZL7
ZFIN ID - ZDB-GENE-040724-172
Ensembl - ENSDARG00000005789
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENPP1ENSGALG00000034397Gallus gallus
 ENPP1ENSG00000197594Homo sapiens
 Enpp1ENSMUSG00000037370Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
enpp2 / ectonucleotide pyrophosphatase/phosphodiesterase 2 / Q13822* / Q9R1E6* / Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 *ENSDARG0000001125742
enpp5 / ectonucleotide pyrophosphatase/phosphodiesterase 5 / Q9EQG7* / Q9UJA9* / ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)* / Mus musculus ectonucleotide pyrophosphatase...ENSDARG0000007062516
enpp4 / Q566N0 / ectonucleotide pyrophosphatase/phosphodiesterase 4 / Q9Y6X5* / Q8BTJ4* / Mus musculus ectonucleotide pyrophosphatase/phosphodiesterase 4 (Enpp4), transcript variant 2, mRNA.*ENSDARG0000000687715
enpp7.1 / ectonucleotide pyrophosphatase/phosphodiesterase 7, tandem duplicate 1 / ENPP7* / Q6UWV6* / ectonucleotide pyrophosphatase/phosphodiesterase 7*ENSDARG0000005352614
enpp6 / ectonucleotide pyrophosphatase/phosphodiesterase 6 / Q6UWR7* / Q8BGN3* / Ectonucleotide pyrophosphatase/phosphodiesterase family member 6 *ENSDARG0000004046913
zgc:153896ENSDARG0000000397713
enpp7.2 / ectonucleotide pyrophosphatase/phosphodiesterase 7, tandem duplicate 2 / ENPP7* / Q6UWV6* / ectonucleotide pyrophosphatase/phosphodiesterase 7*ENSDARG0000005352513


Protein motifs (from Interpro)
Interpro ID Name
 IPR001212  Somatomedin B domain
 IPR001604  DNA/RNA non-specific endonuclease
 IPR002591  Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase
 IPR017849  Alkaline phosphatase-like, alpha/beta/alpha
 IPR017850  Alkaline-phosphatase-like, core domain superfamily
 IPR020821  Extracellular Endonuclease, subunit A


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0030500 regulation of bone mineralization IMP
 biological_processGO:0055062 phosphate ion homeostasis IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0005044 scavenger receptor activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0030247 polysaccharide binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Vitamin B2 (riboflavin) metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000006 ball ball integument calcified , abnormal
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 ZFA:0000107 eye eye calcified , abnormal
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 ZFA:0000114 heart heart calcified , abnormal
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 ZFA:0000135 notochord notochord calcified , abnormal
notochord bone mineralization moderate intensity , abnormal
notochord bone mineralization severe intensity , abnormal
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 ZFA:0000173 bulbus arteriosus bulbus arteriosus calcified , abnormal
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 ZFA:0000184 cleithrum cleithrum nodular , abnormal
cleithrum calcified , abnormal
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 ZFA:0000257 pectoral fin cartilage pectoral fin cartilage calcified , abnormal
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 ZFA:0000368 integument integument osteoclast mislocalised , abnormal
integument mineralized , abnormal
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 ZFA:0000519 hemal arch hemal arch fused with hemal arch , abnormal
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 ZFA:0000737 cranium cranium calcified , abnormal
cranium osteoclast mislocalised , abnormal
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 ZFA:0001066 neural arch neural arch fused with neural arch , abnormal
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 ZFA:0001094 whole organism whole organism phosphodiesterase I activity decreased occurrence , abnormal
whole organism decreased length , abnormal
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 ZFA:0001123 axial fin skeleton axial fin skeleton mineralized , abnormal
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 ZFA:0001135 neural tube neural tube calcified , abnormal
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 ZFA:0001189 vertebra vertebra bone mineralization increased occurrence , abnormal
vertebra bone resorption increased occurrence , abnormal
vertebra osteoclast mislocalised , abnormal
vertebra centrum fused with centrum , abnormal
vertebra fused with vertebra , abnormal
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 ZFA:0001261 ventricular system ventricular system calcified , abnormal
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 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage bone mineralization increased occurrence , abnormal
ceratohyal cartilage perichondral ossification premature , abnormal
ceratohyal cartilage bone tissue mislocalised , abnormal
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 ZFA:0001405 ethmoid cartilage ethmoid cartilage calcified , abnormal
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 ZFA:0005744 notochord outer sheath cell notochord outer sheath cell mineralized , abnormal
notochord outer sheath cell bone mineralization increased occurrence , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000005789 enpp1 / ectonucleotide pyrophosphatase/phosphodiesterase 1 / P22413* / ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform 3 *  / complex






 

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