Manteia - Molecule gene

ENSMUSG00000037370

Mus musculus

Features

Gene ID:	ENSMUSG00000037370

Biological name :	Enpp1

Synonyms :	ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform 3 / Enpp1

Possible biological names infered from orthology :	ectonucleotide pyrophosphatase/phosphodiesterase 1 / P22413

Species:	Mus musculus

Chr. number:	10
Strand:	-1
Band:	A4
Gene start:	24637914
Gene end:	24712159

Corresponding Affymetrix probe sets:	10368289 (MoGene1.0st) 1419276_at (Mouse Genome 430 2.0 Array) 1440339_at (Mouse Genome 430 2.0 Array) 1459546_s_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000114273 Ensembl peptide - ENSMUSP00000046090 Ensembl peptide - ENSMUSP00000101159 NCBI entrez gene - 18605 See in Manteia. MGI - MGI:97370 RefSeq - XM_006512599 RefSeq - NM_001308327 RefSeq - NM_001308329 RefSeq - NM_008813 RefSeq - XM_006512598 RefSeq Peptide - NP_001295256 RefSeq Peptide - NP_001295258 RefSeq Peptide - NP_032839 swissprot - A0A0R4J1Q7 swissprot - G3X9S2 swissprot - E9QQ26 Ensembl - ENSMUSG00000037370

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
enpp1	ENSDARG00000005789	Danio rerio
ENPP1	ENSGALG00000034397	Gallus gallus
ENPP1	ENSG00000197594	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Enpp3 / Q6DYE8 / Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 Alkaline phosphodiesterase I Nucleotide pyrophosphatase / O14638* / ectonucleotide pyrophosphatase/phosphod...	ENSMUSG00000019989	47
Enpp2 / Q9R1E6 / Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 / Q13822* / ectonucleotide pyrophosphatase/phosphodiesterase 2*	ENSMUSG00000022425	40
Enpp4 / Q8BTJ4 / Mus musculus ectonucleotide pyrophosphatase/phosphodiesterase 4 (Enpp4), transcript variant 2, mRNA. / Q9Y6X5* / ectonucleotide pyrophosphatase/phosphodiesterase 4*	ENSMUSG00000023961	18
Enpp7 / ectonucleotide pyrophosphatase/phosphodiesterase 7 / Q6UWV6*	ENSMUSG00000046697	15
Enpp5 / Q9EQG7 / Mus musculus ectonucleotide pyrophosphatase/phosphodiesterase 5 (Enpp5), transcript variant 7, mRNA. / Q9UJA9* / ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)*	ENSMUSG00000023960	15
Enpp6 / Q8BGN3 / Ectonucleotide pyrophosphatase/phosphodiesterase family member 6 / Q6UWR7* / ectonucleotide pyrophosphatase/phosphodiesterase 6*	ENSMUSG00000038173	14

Protein motifs (from Interpro)

Interpro ID	Name
IPR001212	Somatomedin B domain
IPR001604	DNA/RNA non-specific endonuclease
IPR002591	Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase
IPR017849	Alkaline phosphatase-like, alpha/beta/alpha
IPR017850	Alkaline-phosphatase-like, core domain superfamily
IPR020436	Somatomedin B, chordata
IPR020821	Extracellular Endonuclease, subunit A
IPR036024	Somatomedin B-like domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006091	generation of precursor metabolites and energy	IEA
biological_process	GO:0006796	phosphate-containing compound metabolic process	IEA
biological_process	GO:0006898	receptor-mediated endocytosis	IEA
biological_process	GO:0006955	immune response	IEA
biological_process	GO:0008152	metabolic process	IEA
biological_process	GO:0009143	nucleoside triphosphate catabolic process	IEA
biological_process	GO:0030308	negative regulation of cell growth	IEA
biological_process	GO:0030505	inorganic diphosphate transport	IEA
biological_process	GO:0030643	cellular phosphate ion homeostasis	IEA
biological_process	GO:0030730	sequestering of triglyceride	IEA
biological_process	GO:0031953	negative regulation of protein autophosphorylation	IEA
biological_process	GO:0032869	cellular response to insulin stimulus	IEA
biological_process	GO:0045599	negative regulation of fat cell differentiation	IEA
biological_process	GO:0045719	negative regulation of glycogen biosynthetic process	IEA
biological_process	GO:0046325	negative regulation of glucose import	IEA
biological_process	GO:0046627	negative regulation of insulin receptor signaling pathway	IEA
biological_process	GO:0050427	3"-phosphoadenosine 5"-phosphosulfate metabolic process	IEA
biological_process	GO:0090305	nucleic acid phosphodiester bond hydrolysis	IEA
cellular_component	GO:0005615	extracellular space	IEA
cellular_component	GO:0005886	plasma membrane	IEA
cellular_component	GO:0009986	cell surface	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
molecular_function	GO:0003676	nucleic acid binding	IEA
molecular_function	GO:0003824	catalytic activity	IEA
molecular_function	GO:0004527	exonuclease activity	IEA
molecular_function	GO:0004528	phosphodiesterase I activity	IEA
molecular_function	GO:0004551	nucleotide diphosphatase activity	IEA
molecular_function	GO:0005044	scavenger receptor activity	IEA
molecular_function	GO:0005158	insulin receptor binding	IEA
molecular_function	GO:0005524	ATP binding	IEA
molecular_function	GO:0016787	hydrolase activity	IEA
molecular_function	GO:0030247	polysaccharide binding	IEA
molecular_function	GO:0042803	protein homodimerization activity	IEA
molecular_function	GO:0046872	metal ion binding	IEA
molecular_function	GO:0047429	nucleoside-triphosphate diphosphatase activity	IEA

Pathways (from Reactome)

Pathway description

Vitamin B2 (riboflavin) metabolism

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000003	abnormal adipose tissue morphology	"structural anomaly of the connective tissue composed of fat cells enmeshed in areolar tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Sell^tm2Hyn/Sell^tm2Hyn Genetic Background: involves: 129S2/SvPas * BALB/c
MP:0000063	reduced bone density	"decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]	Show Allelic Composition: Enpp1^m1Amgn/Enpp1^m1Amgn Genetic Background: involves: C3H/HeSnJ * C57BL/6J * Swiss
MP:0000066	osteoporosis	"reduction in bone mass or atrophy of skeletal tissue; may lead to skeletal fragility" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]	Show Allelic Composition: Grid2^ho-17J/Grid2^ho-17J Genetic Background: C57BL/6J-Grid2^ho-17J/J
MP:0000130	abnormal cancellous bone morphology	"structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Sell^tm2Hyn/Sell^tm2Hyn Genetic Background: involves: 129S2/SvPas * BALB/c
MP:0000137	abnormal vertebrae morphology	"malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Grid2^ho-17J/Grid2^ho-17J Genetic Background: C57BL/6J-Grid2^ho-17J/J
MP:0000161	scoliosis	"lateral and rotational curvature of the spine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53770, J:66943]	Show Allelic Composition: Enpp1^asj-2J/Enpp1^asj-2J Genetic Background: BALB/cJ-Enpp1^asj-2J/GrsrJ
MP:0000164	abnormal cartilage development	"anomalous formation of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Sell^tm2Hyn/Sell^tm2Hyn Genetic Background: involves: 129S2/SvPas * BALB/c
MP:0000166	abnormal chondrocyte morphology	"anomalous structure, organization, or differentiation of nondividing cartilage cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]	Show Allelic Composition: Grid2^ho-17J/Grid2^ho-17J Genetic Background: C57BL/6J-Grid2^ho-17J/J
MP:0000192	abnormal mineral level	"anomalous concentration of any inorganic substance that has importance in body functions" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Enpp1^asj/Enpp1^asj Genetic Background: C57BL/6J-Enpp1^asj/GrsrJ
MP:0000198	hypophosphatemia	"abnormally low concentrations of phosphates in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Grid2^ho-17J/Grid2^ho-17J Genetic Background: C57BL/6J-Grid2^ho-17J/J Allelic Composition: Enpp1^asj-2J/Enpp1^asj-2J Genetic Background: BALB/cJ-Enpp1^asj-2J/GrsrJ
MP:0000272	abnormal aorta morphology	"structural anomaly of the main trunk of the systemic arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Enpp1^asj/Enpp1^asj Genetic Background: C57BL/6J-Enpp1^asj/GrsrJ
MP:0000955	abnormal spinal cord morphology	"malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Enpp1^m1Amgn/Enpp1^m1Amgn Genetic Background: involves: C3H/HeSnJ * C57BL/6J * Swiss
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Grid2^ho-17J/Grid2^ho-17J Genetic Background: C57BL/6J-Grid2^ho-17J/J
MP:0001325	abnormal retina morphology	"structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Enpp1^asj/Enpp1^asj Genetic Background: C57BL/6J-Enpp1^asj/GrsrJ
MP:0001406	abnormal gait	"unusual or distinctive way of walking" [J:65038]	Show Allelic Composition: Grid2^ho-17J/Grid2^ho-17J Genetic Background: C57BL/6J-Grid2^ho-17J/J Allelic Composition: Enpp1^m1Amgn/Enpp1^m1Amgn Genetic Background: involves: C3H/HeSnJ * C57BL/6J * Swiss Allelic Composition: Enpp1^asj/Enpp1^asj Genetic Background: C57BL/6J-Enpp1^asj/GrsrJ Allelic Composition: Enpp1^asj-2J/Enpp1^asj-2J Genetic Background: BALB/cJ-Enpp1^asj-2J/GrsrJ
MP:0001504	abnormal posture	"atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]	Show Allelic Composition: Cd22^m2Btlr/Cd22^m2Btlr Genetic Background: C57BL/6J-Cd22^m2Btlr
MP:0001505	hunched posture	"stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]	Show Allelic Composition: Enpp1^asj-2J/Enpp1^asj-2J Genetic Background: BALB/cJ-Enpp1^asj-2J/GrsrJ
MP:0001515	abnormal grip strength	"altered ability to grasp and hold objects, usually measured as time spent hanging from an object or wire" [J:80661]	Show Allelic Composition: Grid2^ho-17J/Grid2^ho-17J Genetic Background: C57BL/6J-Grid2^ho-17J/J
MP:0001533	abnormal skeleton physiology	"anomalous function of the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Grid2^ho-17J/Grid2^ho-17J Genetic Background: C57BL/6J-Grid2^ho-17J/J Allelic Composition: Cst10^tm1Hkaw/Cst10^tm1Hkaw,Enpp1^ttw/Enpp1^ttw Genetic Background: involves: C57BL/6 * ICR
MP:0001562	abnormal circulating calcium level	"anomalous concentration in the blood of this bivalent element" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cd22^m2Btlr/Cd22^m2Btlr Genetic Background: C57BL/6J-Cd22^m2Btlr
MP:0001565	abnormal circulating phosphate level	"anomalous blood concentrations of this salt or ester of phosphoric acid; often associated with anomalous bone mineralization " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Cd22^m2Btlr/Cd22^m2Btlr Genetic Background: C57BL/6J-Cd22^m2Btlr
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Grid2^ho-17J/Grid2^ho-17J Genetic Background: C57BL/6J-Grid2^ho-17J/J
MP:0002066	abnormal motor capabilities/coordination/movement	"altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Sell^tm2Hyn/Sell^tm2Hyn Genetic Background: involves: 129S2/SvPas * BALB/c
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Grid2^ho-17J/Grid2^ho-17J Genetic Background: C57BL/6J-Grid2^ho-17J/J
MP:0002114	abnormal axial skeleton morphology	"abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Grid2^ho-17J/Grid2^ho-17J Genetic Background: C57BL/6J-Grid2^ho-17J/J
MP:0002135	abnormal kidney morphology	"abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Dab1^tm1.1Mull/Dab1^tm1.1Mull Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0002896	abnormal bone mineralization	"defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Grid2^ho-17J/Grid2^ho-17J Genetic Background: C57BL/6J-Grid2^ho-17J/J
MP:0002932	abnormal joint	"defect in the articulation point of two or more bones" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Grid2^ho-17J/Grid2^ho-17J Genetic Background: C57BL/6J-Grid2^ho-17J/J Allelic Composition: Enpp1^m1Amgn/Enpp1^m1Amgn Genetic Background: involves: C3H/HeSnJ * C57BL/6J * Swiss Allelic Composition: Enpp1^asj/Enpp1^asj Genetic Background: C57BL/6J-Enpp1^asj/GrsrJ Allelic Composition: Enpp1^asj-2J/Enpp1^asj-2J Genetic Background: BALB/cJ-Enpp1^asj-2J/GrsrJ
MP:0002933	joint inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the joints" [RGD:Rat Genome Database submission]	Show Allelic Composition: Enpp1^asj/Enpp1^asj Genetic Background: C57BL/6J-Enpp1^asj/GrsrJ
MP:0003189	fused joints		Show Allelic Composition: Sell^tm2Hyn/Sell^tm2Hyn Genetic Background: involves: 129S2/SvPas * BALB/c Allelic Composition: Enpp1^tm1Gdg/Enpp1^tm1Gdg Genetic Background: involves: 129S1/Sv
MP:0003195	calcinosis	"pathologic deposition of calcium salts in tissues " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]	Show Allelic Composition: Grid2^ho-17J/Grid2^ho-17J Genetic Background: C57BL/6J-Grid2^ho-17J/J Allelic Composition: Enpp1^asj/Enpp1^asj Genetic Background: C57BL/6J-Enpp1^asj/GrsrJ Allelic Composition: Enpp1^asj-2J/Enpp1^asj-2J Genetic Background: BALB/cJ-Enpp1^asj-2J/GrsrJ Allelic Composition: Enpp1^asj-2J/Enpp1⁺ Genetic Background: BALB/cJ-Enpp1^asj-2J/GrsrJ
MP:0003196	skin calcification	"pathologic deposition of calcium salts in the skin" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Enpp1^asj/Enpp1^asj Genetic Background: C57BL/6J-Enpp1^asj/GrsrJ Allelic Composition: Enpp1^asj-2J/Enpp1^asj-2J Genetic Background: BALB/cJ-Enpp1^asj-2J/GrsrJ
MP:0003197	kidney calcification	"pathologic deposition of calcium salts in the kidney" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]	Show Allelic Composition: Enpp1^asj-2J/Enpp1^asj-2J Genetic Background: BALB/cJ-Enpp1^asj-2J/GrsrJ Allelic Composition: Enpp1^asj-2J/Enpp1⁺ Genetic Background: BALB/cJ-Enpp1^asj-2J/GrsrJ
MP:0003198	tendon calcification	"pathologic deposition of calcium salts in the tendons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]	Show Allelic Composition: Grid2^ho-17J/Grid2^ho-17J Genetic Background: C57BL/6J-Grid2^ho-17J/J Allelic Composition: Enpp1^tm1Gdg/Enpp1^tm1Gdg Genetic Background: involves: 129S1/Sv Allelic Composition: Enpp1^m1Amgn/Enpp1^m1Amgn Genetic Background: involves: C3H/HeSnJ * C57BL/6J * Swiss
MP:0003200	joint calcification	"pathologic deposition of calcium salts in the joints" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]	Show Allelic Composition: Grid2^ho-17J/Grid2^ho-17J Genetic Background: C57BL/6J-Grid2^ho-17J/J Allelic Composition: Enpp1^m1Amgn/Enpp1^m1Amgn Genetic Background: involves: C3H/HeSnJ * C57BL/6J * Swiss Allelic Composition: Enpp1^asj-2J/Enpp1^asj-2J Genetic Background: BALB/cJ-Enpp1^asj-2J/GrsrJ
MP:0003560	osteoarthritis	"a type of arthritis that is caused by the breakdown and eventual loss of the cartilage of one or more joints" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95374]	Show Allelic Composition: Grid2^ho-17J/Grid2^ho-17J Genetic Background: C57BL/6J-Grid2^ho-17J/J Allelic Composition: Enpp1^asj/Enpp1^asj Genetic Background: C57BL/6J-Enpp1^asj/GrsrJ
MP:0003653	decreased skin turgor	"reduced ability of the skin to resist deformation; influential factors include dehydration and age" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Sell^tm2Hyn/Sell^tm2Hyn Genetic Background: involves: 129S2/SvPas * BALB/c
MP:0004016	decreased bone mass	"a reduction in the total amount of bone tissue contained in the skeleton" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Enpp1^m1Amgn/Enpp1^m1Amgn Genetic Background: involves: C3H/HeSnJ * C57BL/6J * Swiss
MP:0004111	abnormal coronary artery morphology	"anomaly of any of the arteries that branch from the aorta to supply blood to the heart" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Enpp1^asj/Enpp1^asj Genetic Background: C57BL/6J-Enpp1^asj/GrsrJ
MP:0004173	abnormal intervertebral disk morphology	"malformation of the cartilagenous and gelatinous structure found between vertebrae" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Grid2^ho-17J/Grid2^ho-17J Genetic Background: C57BL/6J-Grid2^ho-17J/J
MP:0004181	abnormal carotid artery morphology	"malformation of any of the four arteries (two on each side of the neck; right and left internal carotid arteries, and right and left external carotid arteries) that deliver oxygen-rich blood from the heart to the head and brain" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Enpp1^asj/Enpp1^asj Genetic Background: C57BL/6J-Enpp1^asj/GrsrJ
MP:0004231	abnormal calcium ion homeostasis	"anomaly in the processes involved in the maintenance of an internal equilibrium of calcium ions within the body or between a cell and its external environment" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Enpp1^asj-2J/Enpp1^asj-2J Genetic Background: BALB/cJ-Enpp1^asj-2J/GrsrJ
MP:0004685	intervertebral calcification	"process in which the cartilaginous and gelatinous structure found between vertebrae becomes hardened due to deposits of calcium salts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Grid2^ho-17J/Grid2^ho-17J Genetic Background: C57BL/6J-Grid2^ho-17J/J Allelic Composition: Enpp1^tm1Gdg/Enpp1^tm1Gdg Genetic Background: involves: 129S1/Sv
MP:0005006	abnormal osteoblast function	"anomalous function of this bone-forming cell, which normally forms an osseous matrix in which it becomes enclosed as an osteocyte " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Sell^tm2Hyn/Sell^tm2Hyn Genetic Background: involves: 129S2/SvPas * BALB/c
MP:0005190	osteomyelitis	"bone inflammation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Enpp1^asj/Enpp1^asj Genetic Background: C57BL/6J-Enpp1^asj/GrsrJ
MP:0005504	abnormal ligament morphology	"structural anomaly of the flexible bands of fibrous tissue that connect the articular extremities of bones " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:45509]	Show Allelic Composition: Grid2^ho-17J/Grid2^ho-17J Genetic Background: C57BL/6J-Grid2^ho-17J/J
MP:0005592	abnormal vascular smooth muscle morphology	"structural anomaly of the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Sell^tm2Hyn/Sell^tm2Hyn Genetic Background: involves: 129S2/SvPas * BALB/c
MP:0006133	arterial calcification	"pathologic deposition of calcium salts in the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Grid2^ho-17J/Grid2^ho-17J Genetic Background: C57BL/6J-Grid2^ho-17J/J Allelic Composition: Enpp1^m1Amgn/Enpp1^m1Amgn Genetic Background: involves: C3H/HeSnJ * C57BL/6J * Swiss Allelic Composition: Enpp1^asj/Enpp1^asj Genetic Background: C57BL/6J-Enpp1^asj/GrsrJ
MP:0006188	retinal calcification	"pathologic deposition of calcium salts in the retina" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Enpp1^asj/Enpp1^asj Genetic Background: C57BL/6J-Enpp1^asj/GrsrJ
MP:0006325	impaired hearing	"reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Enpp1^asj/Enpp1^asj Genetic Background: C57BL/6J-Enpp1^asj/GrsrJ
MP:0006357	abnormal circulating mineral level	"anomalous concentration in the blood of any naturally occurring, homogeneous inorganic solid substance having a definite chemical composition and highly ordered atomic arrangement that is required for growth and survival" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Enpp1^asj-2J/Enpp1^asj-2J Genetic Background: BALB/cJ-Enpp1^asj-2J/GrsrJ
MP:0008069	abnormal joint mobility	"anomaly in the ability to move joints in a full range of motion and with ease" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Enpp1^m1Amgn/Enpp1^m1Amgn Genetic Background: involves: C3H/HeSnJ * C57BL/6J * Swiss Allelic Composition: Enpp1^asj-2J/Enpp1^asj-2J Genetic Background: BALB/cJ-Enpp1^asj-2J/GrsrJ
MP:0009393	abnormal resting posture	"atypical position of the limbs compared to normal carriage when the body is inactive" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Enpp1^asj/Enpp1^asj Genetic Background: C57BL/6J-Enpp1^asj/GrsrJ
MP:0009763	increased sensitivity to induced morbidity/mortality	"decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Enpp1^asj/Enpp1^asj Genetic Background: C57BL/6J-Enpp1^asj/GrsrJ
MP:0009820	abnormal liver vasculature morphology	"any structural anomaly of the blood vessel network of the bile-secreting exocrine gland" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Enpp1^asj/Enpp1^asj Genetic Background: C57BL/6J-Enpp1^asj/GrsrJ
MP:0009877	exostosis	"a projection of bone, sometimes a benign tumor, that is capped by cartilage and arises from a bone that develops from cartilage" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Enpp1^m1Amgn/Enpp1^m1Amgn Genetic Background: involves: C3H/HeSnJ * C57BL/6J * Swiss
MP:0010124	decreased bone mineral content	"reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Enpp1^m1Amgn/Enpp1^m1Amgn Genetic Background: involves: C3H/HeSnJ * C57BL/6J * Swiss
MP:0010234	abnormal vibrissa follicle morphology	"any structural anomaly of one of the tubular invaginations of the epidermis enclosing the hair roots and from which grow the vibrissae located on the muzzle and face of many species" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Enpp1^asj/Enpp1^asj Genetic Background: C57BL/6J-Enpp1^asj/GrsrJ Allelic Composition: Enpp1^asj-2J/Enpp1^asj-2J Genetic Background: BALB/cJ-Enpp1^asj-2J/GrsrJ
MP:0010522	aorta calcification	"pathologic deposition of calcium salts in the aorta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sell^tm2Hyn/Sell^tm2Hyn Genetic Background: involves: 129S2/SvPas * BALB/c Allelic Composition: Enpp1^m1Amgn/Enpp1^m1Amgn Genetic Background: involves: C3H/HeSnJ * C57BL/6J * Swiss Allelic Composition: Enpp1^asj/Enpp1^asj Genetic Background: C57BL/6J-Enpp1^asj/GrsrJ Allelic Composition: Enpp1^asj-2J/Enpp1^asj-2J Genetic Background: BALB/cJ-Enpp1^asj-2J/GrsrJ
MP:0010678	abnormal skin adnexa morphology	"any structural anomaly of the tissue or structures associated with or embedded in the skin such as hair and hair follicles, sweat glands, sebaceous glands and claws or nails" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Enpp1^asj/Enpp1^asj Genetic Background: C57BL/6J-Enpp1^asj/GrsrJ
MP:0011584	increased alkaline phosphatase activity	"greater ability to catalyze the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum" [GO:0004035]	Show Allelic Composition: Grid2^ho-17J/Grid2^ho-17J Genetic Background: C57BL/6J-Grid2^ho-17J/J
MP:0013941	abnormal enthesis morphology	"any structural anomaly of the connective tissue between tendon and bone insertion sites; the area which acts to transmit tensile load from soft tissues to bone; they may be of the dense fibrous connective tissue or fibrocartilage type; fibrous entheses attach directly to bone or periosteum primarily via fibrous tissue, and fibrocartilaginous entheses attach to bone through a transitional layer of fibrocartilage from the fibrous tendon tissue" [PMID:25489552]	Show Allelic Composition: Grid2^ho-17J/Grid2^ho-17J Genetic Background: C57BL/6J-Grid2^ho-17J/J
MP:0014099	abnormal chondrocyte proliferation	"any anomaly in multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population" [GO:0035988]	Show Allelic Composition: Grid2^ho-17J/Grid2^ho-17J Genetic Background: C57BL/6J-Grid2^ho-17J/J
MP:0020039	increased bone ossification	"increase in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597]	Show Allelic Composition: Enpp1^tm1Gdg/Enpp1^tm1Gdg Genetic Background: involves: 129S1/Sv

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000037370	Enpp1 / ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform 3 / P22413* / ectonucleotide pyrophosphatase/phosphodiesterase 1*	/ complex

1 s.

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