ENSMUSG00000022425


Mus musculus

Features
Gene ID: ENSMUSG00000022425
  
Biological name :Enpp2
  
Synonyms : Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 / Enpp2 / Q9R1E6
  
Possible biological names infered from orthology : ectonucleotide pyrophosphatase/phosphodiesterase 2 / Q13822
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: D1
Gene start: 54838901
Gene end: 54952892
  
Corresponding Affymetrix probe sets: 10428619 (MoGene1.0st)   1415894_at (Mouse Genome 430 2.0 Array)   1443224_at (Mouse Genome 430 2.0 Array)   1448136_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000154729
Ensembl peptide - ENSMUSP00000036180
Ensembl peptide - ENSMUSP00000128941
Ensembl peptide - ENSMUSP00000132640
Ensembl peptide - ENSMUSP00000133877
Ensembl peptide - ENSMUSP00000154470
NCBI entrez gene - 18606     See in Manteia.
MGI - MGI:1321390
RefSeq - XM_017316506
RefSeq - NM_001136077
RefSeq - NM_001285994
RefSeq - NM_001285995
RefSeq - NM_015744
RefSeq - XM_006520596
RefSeq - XM_006520598
RefSeq - XM_011245510
RefSeq - XM_017316503
RefSeq - XM_017316504
RefSeq - XM_017316505
RefSeq - XM_006520593
RefSeq - XM_006520594
RefSeq - XM_006520595
RefSeq Peptide - NP_001129549
RefSeq Peptide - NP_001272923
RefSeq Peptide - NP_001272924
RefSeq Peptide - NP_056559
swissprot - Q9R1E6
swissprot - G3UXY9
Ensembl - ENSMUSG00000022425
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 enpp2ENSDARG00000011257Danio rerio
 ENPP2ENSGALG00000032746Gallus gallus
 ENPP2ENSG00000136960Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Enpp3 / Q6DYE8 / Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 Alkaline phosphodiesterase I Nucleotide pyrophosphatase / O14638* / ectonucleotide pyrophosphatase/phosphod...ENSMUSG0000001998943
Enpp1 / ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform 3 / P22413* / ectonucleotide pyrophosphatase/phosphodiesterase 1*ENSMUSG0000003737040
Enpp4 / Q8BTJ4 / Mus musculus ectonucleotide pyrophosphatase/phosphodiesterase 4 (Enpp4), transcript variant 2, mRNA. / Q9Y6X5* / ectonucleotide pyrophosphatase/phosphodiesterase 4*ENSMUSG0000002396115
Enpp7 / ectonucleotide pyrophosphatase/phosphodiesterase 7 / Q6UWV6*ENSMUSG0000004669714
Enpp5 / Q9EQG7 / Mus musculus ectonucleotide pyrophosphatase/phosphodiesterase 5 (Enpp5), transcript variant 7, mRNA. / Q9UJA9* / ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)*ENSMUSG0000002396013
Enpp6 / Q8BGN3 / Ectonucleotide pyrophosphatase/phosphodiesterase family member 6 / Q6UWR7* / ectonucleotide pyrophosphatase/phosphodiesterase 6*ENSMUSG0000003817312


Protein motifs (from Interpro)
Interpro ID Name
 IPR001212  Somatomedin B domain
 IPR001604  DNA/RNA non-specific endonuclease
 IPR002591  Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase
 IPR017849  Alkaline phosphatase-like, alpha/beta/alpha
 IPR017850  Alkaline-phosphatase-like, core domain superfamily
 IPR020436  Somatomedin B, chordata
 IPR020821  Extracellular Endonuclease, subunit A
 IPR029881  Ectonucleotide pyrophosphatase/phosphodiesterase family member 2
 IPR036024  Somatomedin B-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006644 phospholipid metabolic process IDA
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009395 phospholipid catabolic process IEA
 biological_processGO:0010634 positive regulation of epithelial cell migration IEA
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0030334 regulation of cell migration IEA
 biological_processGO:0034638 phosphatidylcholine catabolic process IEA
 biological_processGO:0045765 regulation of angiogenesis IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 biological_processGO:2000394 positive regulation of lamellipodium morphogenesis IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005887 integral component of plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004528 phosphodiesterase I activity IEA
 molecular_functionGO:0004551 nucleotide diphosphatase activity IEA
 molecular_functionGO:0004622 lysophospholipase activity IEA
 molecular_functionGO:0005044 scavenger receptor activity IEA
 molecular_functionGO:0005509 calcium ion binding IDA
 molecular_functionGO:0008270 zinc ion binding IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0030247 polysaccharide binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mfap2tm1Mech/Mfap2+
Genetic Background: B6.129X1-Mfap2tm1Mech

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Cnbpm1Hrb/Cnbp+
Genetic Background: B6.129S4-Cnbpm1Hrb

Allelic Composition: Enpp2tm1.1Vart/Enpp2tm1.1Vart
Genetic Background: B6.Cg-Enpp2tm1.1Vart/Flmg

Allelic Composition: Enpp2tm1.1Vart/Enpp2tm1.1Vart,Sox1tm2Vep/Sox1+
Genetic Background: involves: C57BL/6

 MP:0000930 wavy neural tube "undulations in the embryonic neural tube" [J:37888]
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Allelic Composition: Cnbpm1Hrb/Cnbp+
Genetic Background: B6.129S4-Cnbpm1Hrb

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cnbpm1Hrb/Cnbp+
Genetic Background: B6.129S4-Cnbpm1Hrb

Allelic Composition: Enpp2tm1.1Vart/Enpp2tm1.1Vart
Genetic Background: B6.Cg-Enpp2tm1.1Vart/Flmg

 MP:0001622 abnormal vasculogenesis "aberrant process of the initial establishment of the vascular network " [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Enpp2tm1.1Vart/Enpp2tm1.1Vart
Genetic Background: B6.Cg-Enpp2tm1.1Vart/Flmg

 MP:0001636 irregular heartbeat "uneven timing of heart contraction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33038]
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Allelic Composition: Mfap2tm1Mech/Mfap2+
Genetic Background: B6.129X1-Mfap2tm1Mech

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Enpp2tm1.1Vart/Enpp2tm1.1Vart
Genetic Background: B6.Cg-Enpp2tm1.1Vart/Flmg

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Ccl2tm1Rol/Ccl2+,Mpztm1Msch/Mpz+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0001719 absent vitelline blood vessels "missing vasculature of the yolk sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62571, J:12623]
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Allelic Composition: Cnbpm1Hrb/Cnbp+
Genetic Background: B6.129S4-Cnbpm1Hrb

 MP:0001726 abnormal allantois "malformed fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]
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Allelic Composition: Enpp2tm1.1Vart/Enpp2tm1.1Vart
Genetic Background: B6.Cg-Enpp2tm1.1Vart/Flmg

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Cnbpm1Hrb/Cnbp+
Genetic Background: B6.129S4-Cnbpm1Hrb

 MP:0002128 abnormal blood circulation "failure or atypical movement in the flow of blood from the heart to the vasculature and back to the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mfap2tm1Mech/Mfap2+
Genetic Background: B6.129X1-Mfap2tm1Mech

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mfap2tm1Mech/Mfap2+
Genetic Background: B6.129X1-Mfap2tm1Mech

Allelic Composition: Enpp2tm1.1Vart/Enpp2tm1.1Vart,Sox1tm2Vep/Sox1+
Genetic Background: involves: C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Notch2tm1Yha/Notch2+
Genetic Background: B6.129-Notch2tm1Yha

Allelic Composition: Enpp2tm1Vart/Enpp2tm1Vart
Genetic Background: B6.Cg-Enpp2tm1Vart/Flmg

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
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Allelic Composition: Enpp2tm1.1Vart/Enpp2tm1.1Vart
Genetic Background: B6.Cg-Enpp2tm1.1Vart/Flmg

Allelic Composition: Enpp2tm1Mmas/Enpp2tm1Mmas
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0003232 abnormal forebrain development "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cnbpm1Hrb/Cnbp+
Genetic Background: B6.129S4-Cnbpm1Hrb

 MP:0003400 kinked neural tube "twists or kinks in the embryonic neural tube" [J:66514, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Cnbpm1Hrb/Cnbp+
Genetic Background: B6.129S4-Cnbpm1Hrb

Allelic Composition: Enpp2tm1.1Vart/Enpp2tm1.1Vart,Sox1tm2Vep/Sox1+
Genetic Background: involves: C57BL/6

 MP:0003651 abnormal axon outgrowth "defect/abnormality in the ability of an axon to extend from a neuron cell body" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96121]
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Allelic Composition: Enpp2tm1.1Vart/Enpp2tm1.1Vart
Genetic Background: B6.Cg-Enpp2tm1.1Vart/Flmg

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cnbpm1Hrb/Cnbp+
Genetic Background: B6.129S4-Cnbpm1Hrb

Allelic Composition: Enpp2tm1.1Vart/Enpp2tm1.1Vart
Genetic Background: B6.Cg-Enpp2tm1.1Vart/Flmg

 MP:0004180 failure of initiation of embryo turning "failure to begin the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Cnbpm1Hrb/Cnbp+
Genetic Background: B6.129S4-Cnbpm1Hrb

Allelic Composition: Enpp2tm1.1Vart/Enpp2tm1.1Vart
Genetic Background: B6.Cg-Enpp2tm1.1Vart/Flmg

Allelic Composition: Enpp2tm1Mmas/Enpp2tm1Mmas
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0004557 dilated allantois "an expansion in the volume of the fetal membrane which contributes to the formation of the umbilical cord and placental blood vessels, as by stretching or distention" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cnbpm1Hrb/Cnbp+
Genetic Background: B6.129S4-Cnbpm1Hrb

 MP:0004560 abnormal chorionic plate morphology "any structural anomaly of the portion of the chorion from which chorionic villi develop that establish a connection with the endometrium, giving rise to the fetal portion of the mature placenta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Enpp2tm1.1Vart/Enpp2tm1.1Vart
Genetic Background: B6.Cg-Enpp2tm1.1Vart/Flmg

 MP:0005033 abnormal trophoblast cells "anomaly of the cells covering the blastocyst that erode the uterine mucosa and contribute to the formation of the placenta " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761]
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Allelic Composition: Enpp2tm1.1Vart/Enpp2tm1.1Vart
Genetic Background: B6.Cg-Enpp2tm1.1Vart/Flmg

 MP:0008554 decreased circulating tumor necrosis factor level "reduction in the amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Nlgn2tm1Bros/Nlgn2tm1Bros,Nlgn3tm1Bros/Nlgn3tm1Bros
Genetic Background: Not Specified

 MP:0008597 decreased circulating interleukin-6 level "reduction in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Nlgn2tm1Bros/Nlgn2tm1Bros,Nlgn3tm1Bros/Nlgn3tm1Bros
Genetic Background: Not Specified

 MP:0008721 abnormal chemokine level "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
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Allelic Composition: Nlgn2tm1Bros/Nlgn2tm1Bros,Nlgn3tm1Bros/Nlgn3tm1Bros
Genetic Background: Not Specified

 MP:0008734 decreased susceptibility to endotoxin shock "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Nlgn2tm1Bros/Nlgn2tm1Bros,Nlgn3tm1Bros/Nlgn3tm1Bros
Genetic Background: Not Specified

 MP:0008762 embryonic lethality "death of an animal in the embryonic period (Mus: up to E14)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Enpp2tm1.1Vart/Enpp2tm1.1Vart,Sox1tm2Vep/Sox1+
Genetic Background: involves: C57BL/6

 MP:0009657 failure of chorioallantoic fusion "failure to initiate and/or complete the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cnbpm1Hrb/Cnbp+
Genetic Background: B6.129S4-Cnbpm1Hrb

Allelic Composition: Enpp2tm1.1Vart/Enpp2tm1.1Vart
Genetic Background: B6.Cg-Enpp2tm1.1Vart/Flmg

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Mapttm1Aha/Mapttm1Aha
Genetic Background: Not Specified

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Cnbpm1Hrb/Cnbp+
Genetic Background: B6.129S4-Cnbpm1Hrb

Allelic Composition: Enpp2tm1.1Vart/Enpp2tm1.1Vart
Genetic Background: B6.Cg-Enpp2tm1.1Vart/Flmg

Allelic Composition: Enpp2tm1Mmas/Enpp2tm1Mmas
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Nlgn2tm1Bros/Nlgn2tm1Bros,Nlgn3tm1Bros/Nlgn3tm1Bros
Genetic Background: Not Specified

 MP:0011186 abnormal visceral endoderm morphology "any structural anomaly of the primitive endoderm-derived tissue which remains in contact with and surrounds the extra-embryonic ectoderm and the epiblast and provides signals for the differentiation and patterning of the epiblast; a small number of visceral endoderm cells also contribute to the endoderm of the embryonic gut" [PMID:21123814]
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Allelic Composition: Enpp2tm1Mmas/Enpp2tm1Mmas
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0012505 increased neural tube apoptosis "increase in the number of cells of the neural tube undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Enpp2tm1.1Vart/Enpp2tm1.1Vart
Genetic Background: B6.Cg-Enpp2tm1.1Vart/Flmg

 MP:0020515 abnormal visceral yolk sac endoderm morphology "any structural anomaly of the portion of the visceral yolk sac consisting of endoderm-derived cells that is responsible for absorption of nutrients" [https://discovery.lifemapsc.com/in-vivo-development/yolk-sac/yolk-sac-endoderm, PMID:20672346]
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Allelic Composition: Enpp2tm1Mmas/Enpp2tm1Mmas
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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