ENSMUSG00000019989


Mus musculus

Features
Gene ID: ENSMUSG00000019989
  
Biological name :Enpp3
  
Synonyms : Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 Alkaline phosphodiesterase I Nucleotide pyrophosphatase / Enpp3 / Q6DYE8
  
Possible biological names infered from orthology : ectonucleotide pyrophosphatase/phosphodiesterase 3 / O14638
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: A4
Gene start: 24772406
Gene end: 24842823
  
Corresponding Affymetrix probe sets: 10368317 (MoGene1.0st)   1425353_at (Mouse Genome 430 2.0 Array)   1427302_at (Mouse Genome 430 2.0 Array)   1427303_at (Mouse Genome 430 2.0 Array)   1439260_a_at (Mouse Genome 430 2.0 Array)   1452384_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000151371
Ensembl peptide - ENSMUSP00000152033
Ensembl peptide - ENSMUSP00000151646
Ensembl peptide - ENSMUSP00000151540
Ensembl peptide - ENSMUSP00000151518
Ensembl peptide - ENSMUSP00000151393
Ensembl peptide - ENSMUSP00000020169
NCBI entrez gene - 209558     See in Manteia.
MGI - MGI:2143702
RefSeq - NM_134005
RefSeq Peptide - NP_598766
swissprot - A0A1W2P751
swissprot - A0A1W2P6R0
swissprot - Q6DYE8
swissprot - A0A1W2P8G4
swissprot - Q91VZ7
swissprot - A0A1W2P7F5
swissprot - A0A1W2P763
Ensembl - ENSMUSG00000019989
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENPP3ENSGALG00000037587Gallus gallus
 ENPP3ENSG00000154269Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Enpp1 / ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform 3 / P22413* / ectonucleotide pyrophosphatase/phosphodiesterase 1*ENSMUSG0000003737048
Enpp2 / Q9R1E6 / Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 / Q13822* / ectonucleotide pyrophosphatase/phosphodiesterase 2*ENSMUSG0000002242545
Enpp5 / Q9EQG7 / Mus musculus ectonucleotide pyrophosphatase/phosphodiesterase 5 (Enpp5), transcript variant 7, mRNA. / Q9UJA9* / ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)*ENSMUSG0000002396017
Enpp4 / Q8BTJ4 / Mus musculus ectonucleotide pyrophosphatase/phosphodiesterase 4 (Enpp4), transcript variant 2, mRNA. / Q9Y6X5* / ectonucleotide pyrophosphatase/phosphodiesterase 4*ENSMUSG0000002396116
Enpp6 / Q8BGN3 / Ectonucleotide pyrophosphatase/phosphodiesterase family member 6 / Q6UWR7* / ectonucleotide pyrophosphatase/phosphodiesterase 6*ENSMUSG0000003817314
Enpp7 / ectonucleotide pyrophosphatase/phosphodiesterase 7 / Q6UWV6*ENSMUSG0000004669714


Protein motifs (from Interpro)
Interpro ID Name
 IPR001212  Somatomedin B domain
 IPR001604  DNA/RNA non-specific endonuclease
 IPR002591  Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase
 IPR017849  Alkaline phosphatase-like, alpha/beta/alpha
 IPR017850  Alkaline-phosphatase-like, core domain superfamily
 IPR020821  Extracellular Endonuclease, subunit A
 IPR036024  Somatomedin B-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006796 phosphate-containing compound metabolic process IEA
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009143 nucleoside triphosphate catabolic process IEA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004528 phosphodiesterase I activity IEA
 molecular_functionGO:0004551 nucleotide diphosphatase activity IEA
 molecular_functionGO:0005044 scavenger receptor activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0030247 polysaccharide binding IEA
 molecular_functionGO:0035529 NADH pyrophosphatase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047429 nucleoside-triphosphate diphosphatase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000324 increased mast cell number "greater than expected number of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fam20ctm1.1Cqi/Fam20ctm1.1Cqi,Tg(Col1a1-cre)2Bek/0
Genetic Background: involves: 129S6/SvEvTac * CD-1

Allelic Composition: Enpp3tm1Ktak/Enpp3tm1Ktak,P2rx7tm1Gab/P2rx7tm1Gab
Genetic Background: either: (involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6) or (involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6)

 MP:0001858 intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Fam20ctm1.1Cqi/Fam20ctm1.1Cqi,Tg(Col1a1-cre)2Bek/0
Genetic Background: involves: 129S6/SvEvTac * CD-1

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Fam20ctm1.1Cqi/Fam20ctm1.1Cqi,Tg(Col1a1-cre)2Bek/0
Genetic Background: involves: 129S6/SvEvTac * CD-1

 MP:0002423 abnormal mast cell physiology "anomalous response of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Fam20ctm1.1Cqi/Fam20ctm1.1Cqi,Tg(Col1a1-cre)2Bek/0
Genetic Background: involves: 129S6/SvEvTac * CD-1

 MP:0002464 abnormal basophil physiology "abnormal function of the leukocyte that contains granules that stain with basic dyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fam20ctm1.1Cqi/Fam20ctm1.1Cqi,Tg(Col1a1-cre)2Bek/0
Genetic Background: involves: 129S6/SvEvTac * CD-1

 MP:0002497 increased IgE "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fam20ctm1.1Cqi/Fam20ctm1.1Cqi,Tg(Col1a1-cre)2Bek/0
Genetic Background: involves: 129S6/SvEvTac * CD-1

 MP:0002606 increased basophil count "higher than average number of basophils as measured by the percent of the total number of leukocytes" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, MPD:Mouse Phenome Database]
Show

Allelic Composition: Fam20ctm1.1Cqi/Fam20ctm1.1Cqi,Tg(Col1a1-cre)2Bek/0
Genetic Background: involves: 129S6/SvEvTac * CD-1

Allelic Composition: Enpp3tm1Ktak/Enpp3tm1Ktak,P2rx7tm1Gab/P2rx7tm1Gab
Genetic Background: either: (involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6) or (involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6)

 MP:0005596 increased susceptibility to type I hypersensitvity reaction "greater likelihood of developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fam20ctm1.1Cqi/Fam20ctm1.1Cqi,Tg(Col1a1-cre)2Bek/0
Genetic Background: involves: 129S6/SvEvTac * CD-1

 MP:0008699 increased interleukin-4 secretion "increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Fam20ctm1.1Cqi/Fam20ctm1.1Cqi,Tg(Col1a1-cre)2Bek/0
Genetic Background: involves: 129S6/SvEvTac * CD-1

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fam20ctm1.1Cqi/Fam20ctm1.1Cqi,Tg(Col1a1-cre)2Bek/0
Genetic Background: involves: 129S6/SvEvTac * CD-1

 MP:0010180 increased susceptibility to weight loss "greater decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fam20ctm1.1Cqi/Fam20ctm1.1Cqi,Tg(Col1a1-cre)2Bek/0
Genetic Background: involves: 129S6/SvEvTac * CD-1

 MP:0013956 decreased colon length "reduced length of the portion of the large intestine between the cecum and the rectum" [ISBN:0683400088]
Show

Allelic Composition: Fam20ctm1.1Cqi/Fam20ctm1.1Cqi,Tg(Col1a1-cre)2Bek/0
Genetic Background: involves: 129S6/SvEvTac * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr