ENSG00000136960


Homo sapiens

Features
Gene ID: ENSG00000136960
  
Biological name :ENPP2
  
Synonyms : ectonucleotide pyrophosphatase/phosphodiesterase 2 / ENPP2 / Q13822
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: q24.12
Gene start: 119557086
Gene end: 119673453
  
Corresponding Affymetrix probe sets: 209392_at (Human Genome U133 Plus 2.0 Array)   210839_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000403315
Ensembl peptide - ENSP00000259486
Ensembl peptide - ENSP00000428291
Ensembl peptide - ENSP00000429476
Ensembl peptide - ENSP00000429447
Ensembl peptide - ENSP00000428304
Ensembl peptide - ENSP00000075322
NCBI entrez gene - 5168     See in Manteia.
OMIM - 601060
RefSeq - XM_017013575
RefSeq - NM_001330600
RefSeq - NM_006209
RefSeq - XM_006716584
RefSeq - XM_006716585
RefSeq - XM_006716587
RefSeq - XM_017013571
RefSeq - XM_017013572
RefSeq - XM_017013573
RefSeq - XM_017013574
RefSeq - NM_001040092
RefSeq - NM_001130863
RefSeq Peptide - NP_001124335
RefSeq Peptide - NP_001317529
RefSeq Peptide - NP_006200
RefSeq Peptide - NP_001035181
swissprot - E7EUF1
swissprot - Q13822
swissprot - E5RJ49
swissprot - E5RIB9
swissprot - E5RIA2
Ensembl - ENSG00000136960
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 enpp2ENSDARG00000011257Danio rerio
 ENPP2ENSGALG00000032746Gallus gallus
 Enpp2ENSMUSG00000022425Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ENPP3 / O14638 / ectonucleotide pyrophosphatase/phosphodiesterase 3ENSG0000015426941
ENPP1 / P22413 / ectonucleotide pyrophosphatase/phosphodiesterase 1ENSG0000019759441
ENPP4 / Q9Y6X5 / ectonucleotide pyrophosphatase/phosphodiesterase 4ENSG0000000156115
ENPP5 / Q9UJA9 / ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)ENSG0000011279613
ENPP7 / Q6UWV6 / ectonucleotide pyrophosphatase/phosphodiesterase 7ENSG0000018215613
ENPP6 / Q6UWR7 / ectonucleotide pyrophosphatase/phosphodiesterase 6ENSG0000016430312


Protein motifs (from Interpro)
Interpro ID Name
 IPR001212  Somatomedin B domain
 IPR001604  DNA/RNA non-specific endonuclease
 IPR002591  Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase
 IPR017849  Alkaline phosphatase-like, alpha/beta/alpha
 IPR017850  Alkaline-phosphatase-like, core domain superfamily
 IPR020436  Somatomedin B, chordata
 IPR020821  Extracellular Endonuclease, subunit A
 IPR029881  Ectonucleotide pyrophosphatase/phosphodiesterase family member 2
 IPR036024  Somatomedin B-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006644 phospholipid metabolic process IEA
 biological_processGO:0006796 phosphate-containing compound metabolic process TAS
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009395 phospholipid catabolic process IDA
 biological_processGO:0010634 positive regulation of epithelial cell migration IMP
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0030334 regulation of cell migration IEA
 biological_processGO:0034638 phosphatidylcholine catabolic process IDA
 biological_processGO:0045765 regulation of angiogenesis IEA
 biological_processGO:0048870 cell motility TAS
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 biological_processGO:2000394 positive regulation of lamellipodium morphogenesis IGI
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space ISS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004528 phosphodiesterase I activity IEA
 molecular_functionGO:0004551 nucleotide diphosphatase activity IEA
 molecular_functionGO:0004622 lysophospholipase activity IEA
 molecular_functionGO:0005044 scavenger receptor activity IEA
 molecular_functionGO:0005509 calcium ion binding ISS
 molecular_functionGO:0008134 transcription factor binding TAS
 molecular_functionGO:0008270 zinc ion binding ISS
 molecular_functionGO:0016787 hydrolase activity TAS
 molecular_functionGO:0030247 polysaccharide binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity IEA


Pathways (from Reactome)
Pathway description
Vitamin B5 (pantothenate) metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000136960 ENPP2 / Q13822 / ectonucleotide pyrophosphatase/phosphodiesterase 2  / complex






 

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