ENSDARG00000008237


Danio rerio

Features
Gene ID: ENSDARG00000008237
  
Biological name :sars
  
Synonyms : Q6DRC0 / sars / seryl-tRNA synthetase
  
Possible biological names infered from orthology : P26638 / P49591 / Serine--tRNA ligase, cytoplasmic
  
Species: Danio rerio
  
Chr. number: 23
Strand: 1
Band:
Gene start: 34030550
Gene end: 34043651
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000015775
NCBI entrez gene - 445405     See in Manteia.
RefSeq - NM_001003882
RefSeq Peptide - NP_001003882
swissprot - Q6DRC0
ZFIN ID - ZDB-GENE-040831-1
Ensembl - ENSDARG00000008237
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SARSENSGALG00000026809Gallus gallus
 SARSENSG00000031698Homo sapiens
 SarsENSMUSG00000068739Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002314  Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)
 IPR002317  Serine-tRNA ligase, type1
 IPR006195  Aminoacyl-tRNA synthetase, class II
 IPR010978  Class I and II aminoacyl-tRNA synthetase, tRNA-binding arm
 IPR015866  Serine-tRNA synthetase, type1, N-terminal
 IPR033729  Serine-tRNA ligase catalytic core domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISS
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0001569 branching involved in blood vessel morphogenesis IMP
 biological_processGO:0006412 translation IEA
 biological_processGO:0006418 tRNA aminoacylation for protein translation IEA
 biological_processGO:0006434 seryl-tRNA aminoacylation ISS
 biological_processGO:0016525 negative regulation of angiogenesis ISS
 biological_processGO:1903671 negative regulation of sprouting angiogenesis IMP
 biological_processGO:1904046 negative regulation of vascular endothelial growth factor production IMP
 cellular_componentGO:0005634 nucleus IMP
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001046 core promoter sequence-specific DNA binding ISS
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004812 aminoacyl-tRNA ligase activity IEA
 molecular_functionGO:0004828 serine-tRNA ligase activity ISS
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016874 ligase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000007 blood blood quality , abnormal
Show

 ZFA:0000029 hindbrain hindbrain blood vasculature branched , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000099 brain vasculature brain vasculature branched , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0000112 gut gut hypoplastic , abnormal
gut quality , abnormal
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 ZFA:0000114 heart heart quality , abnormal
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 ZFA:0000123 liver liver hypoplastic , abnormal
liver quality , abnormal
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 ZFA:0001094 whole organism whole organism increased amount , abnormal
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 ZFA:0001114 head head decreased size , abnormal
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 ZFA:0001115 trunk trunk intersegmental vessel increased branchiness , abnormal
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 ZFA:0001267 cranial vasculature cranial vasculature increased diameter , abnormal
cranial vasculature branchiness , abnormal
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 ZFA:0001285 intersegmental vessel intersegmental vessel branched , abnormal
intersegmental vessel cell increased amount , abnormal
intersegmental vessel increased branchiness , abnormal
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 ZFA:0001439 anatomical system anatomical system quality , abnormal
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 ZFA:0005004 aortic arch aortic arch dilated , abnormal
aortic arch increased diameter , abnormal
Show

 ZFA:0005024 trunk vasculature trunk vasculature branchiness , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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