ENSG00000031698


Homo sapiens

Features
Gene ID: ENSG00000031698
  
Biological name :SARS
  
Synonyms : P49591 / SARS / seryl-tRNA synthetase
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p13.3
Gene start: 109213918
Gene end: 109238169
  
Corresponding Affymetrix probe sets: 200802_at (Human Genome U133 Plus 2.0 Array)   231894_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000234677
Ensembl peptide - ENSP00000358939
NCBI entrez gene - 6301     See in Manteia.
OMIM - 607529
RefSeq - XM_006710813
RefSeq - NM_001330669
RefSeq - NM_006513
RefSeq Peptide - NP_006504
RefSeq Peptide - NP_001317598
swissprot - P49591
swissprot - Q5T5C7
Ensembl - ENSG00000031698
  
Related genetic diseases (OMIM): 617709 - ?Neurodevelopmental disorder with microcephaly, ataxia, and seizures, 617709
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sarsENSDARG00000008237Danio rerio
 SARSENSGALG00000026809Gallus gallus
 SarsENSMUSG00000068739Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002314  Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)
 IPR002317  Serine-tRNA ligase, type1
 IPR006195  Aminoacyl-tRNA synthetase, class II
 IPR010978  Class I and II aminoacyl-tRNA synthetase, tRNA-binding arm
 IPR015866  Serine-tRNA synthetase, type1, N-terminal
 IPR033729  Serine-tRNA ligase catalytic core domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006412 translation TAS
 biological_processGO:0006418 tRNA aminoacylation for protein translation IEA
 biological_processGO:0006434 seryl-tRNA aminoacylation IEA
 biological_processGO:0008033 tRNA processing TAS
 biological_processGO:0016259 selenocysteine metabolic process TAS
 biological_processGO:0016525 negative regulation of angiogenesis IMP
 biological_processGO:0097056 selenocysteinyl-tRNA(Sec) biosynthetic process IEA
 biological_processGO:1904046 negative regulation of vascular endothelial growth factor production IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001046 core promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003723 RNA binding TAS
 molecular_functionGO:0004812 aminoacyl-tRNA ligase activity IEA
 molecular_functionGO:0004828 serine-tRNA ligase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016874 ligase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0098619 selenocysteine-tRNA ligase activity TAS


Pathways (from Reactome)
Pathway description
Selenocysteine synthesis
Cytosolic tRNA aminoacylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000031698 SARS / P49591 / seryl-tRNA synthetase  / complex






 

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